” autherit ’ ere easy on 2 Ria 60 ais Chemical Corps Reseercn an Neveloprnent Command Bite2s vor BIOLOGICAL WARFARE LA! -TORLES _U- 4 Fort Detcsick, Frecerick, Many gad _ : heturn this corresvondence +.” tu ace me wee ssUn, = Post Headquarters for Records File AQ a ps we vw A = — ot nde. . _e@ lorvord, a, Srte? ovt-Lline of 4°) investifated ascns, MECe, D, Machanism, mate, 2. “Loroscopical Invistiration in detsils, nerve, a, deart, yare. TG . 3, Lune rare, (07 @. Toned. pare, 139 f, aw Lig . y woe eo y,, I al ann x. i, x, : pare, vare, 16a Stomach and Intestines. nara, (8x Snleon, vere, IZ nidnev, pare Penavnus, carn, ALY Sucra-renal vland. care, AIR 4hyroid. Tae ~ mate perch esoces have investiget&éd 50 cases of anthrax disease, which could be! " olaweitiea into 3 groups: a) . Percutaneous infection: . I case, 8 eer ») ' Pe#oral infection: fs) ceses, “ oe co) Pernasal infection: 20 cases. =: wit ee ikaneoas infection: 1 eoaee i Case Days 0 n Pathological changes Course a! 1, :No 64, 7 @ays, — Localised cutaneous ulcers and perifocal ee Sy " phlegmons (r-thigh) ' Some parenchymatous degeneration: 4 : ‘Heart: Intense degeneration and interstitial - “edema, ete liver: Hepatitis serosa III, accompanied:with - some hemorrhagic changes. a2 8 . a Kidney: Glomerulo/nephrosis, with vacuolar i : ‘degeneration of epithliums. —. hee: | a : - Spleen: Splenitie infectiona b) Peroral Anfection: : 9 agen were infected perorally with some food atutte, which contatn some. quantity of: anthrax bacillus and all patients died definitely - after several days by acute abdominal symptoms and severe hhonorrhagie: - ; ascites, : a 5 ; ae ¢ ’ iméntary canals: ocuured no remarkable oe in = stone val tage Membrene with hemorrhagic leucocytic reactions) of intestines, especia- lly at tleococceal portcions, lower perts of ilew: or sometimes all over the intestinal tracts (upser parts of ileum, duedenoun, jejunem or large intettine), accompenied with intense gelatinous (exudative) swelling of mesenterial fatty tissues and followine severe hemorrhagic ascites, whish caused the death. Renpresentive records of 6 cases: Cause Dys of rein Pechological changes counse i nC Ot ewer en eo nn 1. No, 218, Z davs, Primery abdominal symptoms: Intense hemorrhagic cxudative changes of inte- stines, accompanied “ith intense hemorrhagic ascites. Secondery matastatic changes: Lung with slight Alveolitis and some bacterial dissemination, Liver with Hepatitis serosa IV and some hemorr- hagic reactions (hemorrhages in central zone of acinus), ileart with some parenchymatous degeneration and partial hemorrhages. xidney with some parenchymatous degenerstion and seme exudative changes. Sopre-renal with diffuse hemorrhages in cortical vissues. Thrreoida in ome tgs I Be. 320... 2 days, Spleen: Splenitis infectiosa. ~ 2. No. 26, days. Primary abdominal symptoms: Intense hemorrhagic -exudative changes of intestines, accompanéd with intense hemorrhagic ascites, Secondary metastatic symtoms: Liver with Hepatitis serosa TIT and partial hemorrhages in central zone and miltiple mili- ary necrosis, 5 Heart with no remarkable changes, Kidney with sme Clomerulo-nephrosis and intenee interstitial edema. Lung with some pulmonal congestion and some metastatic bacterial dissemination. Spleen: ‘Sptenitis infectiosa, Primary abdominal symptoms: _ Intense hemorrhagic exudative swelling of intes~ tines, accompanied with intense hemorrhegic ascites, Secondary metastatic changes: Liver with slight Hepatitis. _ Heart with some interstitial edema]. Kidney with Sonsiderable Glomerulo-nephrosis and slight interstitial edema, Pancreas with moderate congestion and ome peri vascular reund cell in iltration, L oe meng a ie ts ; Supra-renal glend withvacuolar degeneration A and multiple hemorrhages in Se hata Splemn Spelenitis infectiosa. 4, 328, ca, 2 dmys. oe | = Primary abdominal syaptome: -! Intense hemorrhagic exudative changes: of- r Anton stines, _accompanied with intense omarirhagte a ascites, ‘s . i Socandary metastatic. = ee Heart with intense degeneration intense onpt~ llary congestion and some ‘hemorrhagi ) Liver with Hepatitis: serosa: III, mas : ; Kidney with Paronohymatous dogenarétion ‘end some, ' Anterstitisl. edema, ot . eg with no. renerkable > change. preys ‘abdominal - aymptonias | a is : - ee Intense hemorrhagic exudative shange Ssoanders metastatic ‘shaneset! Heart with dntose Gesrnenaece ane intense interstitial edena. ee a of Liver with Hepatitis serosa. ee Tite with moderate diffuse Aaveolstde gra” ‘some ce ‘ ea bacterial dissemination,’ pote Kidney with moderate Glomernlo-nephnoeis: and” intense interstitial edema. Supra-renel gland with intense vaonoler. See a degeneration, 3 oy Spleen: aes infectiosa, ett ee dP eyetiee eee Ld Se ce ee 6. I7, ca 2 daye. Prinery sbdominal symptoms: oe “tines, eocompanied with intense henbrrhests oe a scites, Seoondery metastatic. -ohanges: io Heart with moderate degeneration. Liver with Hepatitia serosa II and. ‘fatty degeneration, Kidney with moderate OLomerule-nest “spleen: Splenttte infaopipeal oS (c) Pernasal infection; Th. few). eee rte) -TOP SECRET TOP SECRET TOP SECRET er ere ee, fonts 2 Tt. ‘eocured: ‘guddeniy al ; About 20 men in the prison were. affected suscosbively with soiled “etry who which contained some quantity of anthrax x Debate nt ated, nal: ayaptoms, _ . _ oe ce At firat they séeplained of acute Monet 1itiatig@ tonsil was the main entrance port, : Then. intense hemorrhagio . changes, due to entre Anfoota in 2 manners: a) ‘Perbronchially, and >) oh. eptronpniet. spread. oustiy. ‘by X-ray test b olintoalty. 3 ; uh anes : ae Perbronslitel sproea, 1 880. ca 8. ‘diya: is Sear | Pinay thoracal a srmptonns 3 days. TOP SECRET Prmary thocracal symptoms: Acute Tonsiplitis. J Acute hemorrhagic Mediastinitie, ; Acte hemorrhagic Peribronchitis and Peribroncht- olitis, (Lymphadenifis heemorrhagica pert ‘pronche: - ‘toals), | i _ Diffuse moderate Alveolitia and reactive hemorrha- gic exudative Plouritis, —__ iss | ‘Secondary metastatic changes: — Near Heart with moderate degeneration and intense - interstitialedema, | - Liver with Hepatitis serosa ITT and ‘some pertoa- . pillary PeUsOsT ree accumlation, Kidney withnoderate Olomeruke-nephrosts ae noderas: te interstitial edema. x a ES Supra -renal glend with intense degeneration. and’ moderate inter -renal gland with intense degenerat - “ton and some locplised hemorrhages. = wae _ ‘Thyreotd in follicular collapse, socmapented with | some bacterial metatasis, ieee oa aa “ Spleen: Sphemitis Gapeoti Gea: 12. on. 3 days. Primary thoracal eymptons: as me _ Aoute pones TL eae : Diffuse Alveolitts and mileivie saemaate Pneumonic places, = ee OS oe ds Tatvg oa “econdary merastatic changes: -- Beart with moderate cegeneration SS " vd bi | chymal reaction, oe Kidney. with slight ‘lomerstsnephreat and 1 Antense, interstatintadne andn igie senéeaauence leucocytes sodtimtation, : oo, _: Pnacreaawith moderate — and. me ote. De SRST Eee eats eps i eNy Hai Je 18 6 SS Carra ette ms teLee 6 arigtadeny Geet tEteresbapbececceesesenrsuceetedeeealuwtcehdsal 4 *: ‘In-one case( No, vey se oe wise ‘Geil 495) acute *onsillitis: ‘tuusedintonseEnedironenitie and - ora mul tple bronchogenous pneumonia. oe ee ee 4, No, 405, ca, 5 days. . meer ae re ic Feaeary thoracal symptoms: Acute Tonsiliitis, "pneumonia. ae Saccidirs matastetio changes! a ee odene. _ldver with: Mopetitis seroeaiiz,, and sone pecivaboul ja Soaeouyiee Supra-renal gland with intense degeneration\vaeuo lar or honeycombed degeneration) and diffuse _ hemorrhages in cortical. tissues, Thyreold in. stafical state. _pleen: splenitic infectionsa. SS ce aS Pancreas withvacuolar degeneration: of cells. emnre Tres gland, with intense, (nage doi . nomortheges. an. cortical tamues. ' PLETE OOT Oe eee renee cence rneeee sees eereteuaeneeerentte Case Gore. _Main pecnol cntcet, neMEERE - thoracat’ Bal 1402. a devs, oe Nbced ana syaptons’ a laver. ,not investigated mi, Tnyreoid in follicular ‘oolleps Spleen: Splemitis infectiosa. my i as , Peary ak Maa ase a ca ee 2 400 3 days. Primary theracal symptoms: Acute hemorrhagic Mediestinitis, Acute hemorrhagic Peribronehitis ned ? pay “ Lymphadenitie haemorrhagica penstbronshisis Acute intense Endobronchitis. Multiple hemorrhagic acinous pheumontc placra j ‘Primary abdominal symptoms! at “Booondary metastatic yishangesi Herat. with: moderate degeneration: ‘and som reaction. Laver. with Hopetitic serosa tt. eee gland + with intese ‘p enchyniat dus. deg "ton, . -. pate, spienjiis antectisas, 6s eee ; Asi e- stienoe hagt ( Lymphadenitis haemorrhagica peribronchiale) Diffues slight Alveolitis. Primary abdominal symptoms: Lymphadenitis haemorrhagioa acuta mesentericae, Acute hemorrhagic ascites. Moderate subnucoud congestion of small intestine, Moderate subnucoux bongestion and some perivascular leuco- oytes accumulation of large intestine, | Secondary metastatic chagnes: oe ‘Herat withmoderate degeneration , ingense edema and ‘some - ' mesenchymal reaction. ; | Liver with Hepatitis derosa IV. _ Kidney with moderate Glomerulo-nephrosis and © me intersti- tial edema. ; Spleen: Splenitis infeotiosa, 4,417 ca 3 days, ; , Primary thoracla symptoms: ‘Tonsillitis acuta, . oo. Acute hemorrhagic Mediastinitis, Acute hemorrhagic Perdbronchitis ond Pertbronchiolits. (Lymphadenitis haemorrhegica peribronshtele), Acute slighr pulmonal congestion. _Primary abdominal. _oymptoms: | ‘Lymphadenitis. soute with slight ¢ exdative © enanges (congestion . and some leucocytes atesemdantion ). + Me No remarkable astites. . Small intestine:some inflammatory changes in submicous tissw with edema, slight hemorrhages and some perivascularroud. _, ¢@11 accumulation, Secondary metastatic changes: ; = Herat wit} intense degenerqtion and moderate interstitial edema, ; . Liver with Hepatitis serosa III, aoe Kidney withslight Glomerulo-nephrosis and medrate : interstitial edema. — Neda Galea , a Supra -renal gland with adiffues emorrhages in cortical tissues and intense spaenorarrgulotenesrotse changes ) .of cortical cells. Thyreoid infollicular Slisees ; pancrene withvacuolar degenertion of parenchymatous cells, sestgesstategesseseeesasscseoensonsensessenslonssconsuneapereness 6 899 3 days, : *rimary thoracal symptoms: Tonaillitis acuta, . Acute hemorrhagic Mediastinitis. Acute hemorrhagic Persbeenchitie. - Ciymphedenttis haemorrhagica pertbronchiale), ‘Slight Pulmonal congestion, Primary abdominal symptoms: a fa Lymphadenitis acuta haemorrhegica mesentericae, Acute hemorrhagic ascites, ; ; Antestines:notinvestigate microscopically, Secondary merastatic changes: ; Heert with moderate degeneration and sme hemorrhégis ohanges, Liver with Hepatitis serosa IIr-1V, ; Kidney with slight ¢1omerulo-nephrosie and. noderate inter~ stitial edema, — ne Supra -renal gland with intense Parenchymatousdegeneration’ and intense hemorrhages in Z. reticulatis). Thyreoid in follicular collapse, . Spleen: "plenitis infectiosa, 6, 393 ce 4 days. | : ous Primary thoracal symptoms: Acute hemorrhagic Mediastini tis. . Acute hemorrhagic Peribronchitie (Lymphadent tis. haemorrhagica peribronchiele). Slight diffues Alveolitis. Pleuritis. exdudative tuberoulose, Primary abdominal symptops: _ i Lymphadenitis “haemorrhagicosnecroticans mesentericae, Acute hemorrhagic ascites. | | ; ; “ Onteatines, can not be Lnvestigated microscopically, ‘Secondary metastatic changes: es i. —- - Heart. with intense degeneration, intense congestion adn alight hemorrhages. . Liver with Hepatitis serosa Iti. ; Kidney with meddrate Shonerule=nerbeoste and moderace inter~ stitial edema. a Pancreas with-mederate-Gremerute some parenchymatous degene- Pation, : Supra-renal gland with intense degeneration, Thyreoid in follicular collapse, i ie ee eee ee ee 7. 390 ca 3 daya, Primary thoracal symptoms: — may ‘Tomsillitis acuta haemorrhagioa, Acute hemorrhagic Mediastinitis. Acute hemorrhagic Peribronchitis and Pertoronohtolitte, (Lymphadenite haemorrhagica peribronchialte),. “Moderete-mt Diffuse ‘Alveolttis rithhenorthegic necrotic > changes at some. . Places, Fanim 27 ‘abdominal syuptoma: ra? ohh Lymphedenitis heemorrhagico-necroticans mosonterioae, Acute hemorrhagic ascites, ee 2 _ Moderate submucous congestion of intestines, ‘Secondary metastatic changes,: Heart with intense deg " ae Fi Pie's = ie Liver, not investigated microscopica ye Kidney, not investigatedmicroscopically. Supra-remal gland with multiple miliary necrosis. a 493 3 days: Primary thorachkA sgmptims: Tonsillitis acuta. Acute hemorrhagic Mediastinitis. Acute hemorrhagic Peribronchitis, (Lympahdenitis haemorrhagica peribronohiale). -Acimo-lobular pneumonia(hemorrhagic leucocytic). Primary abdominal’ symptoms: Lymphadenitis heemorrhagico-necroticans mesentericae, Aoute hemorrhagic ascites, Moderate oatarrh of intestines, Secondary metastatic changes’ Heart with moderate decaiicieeetens and some. Endoarteritis of blood-vessels, accompanied with some round cell avin’ lation. . 7 Liver with Hepatitis serosa III, accomapanied with some bacillus in capillaries, Kideney withslight ‘Gloperclo-nephrosis and . mederate interstitial edema, " * S-Panereas withmoderste degeneration, Thyraoid in follicular collapse. SOTHO He He eHeTeOe Owe HOLES HH EF EE EE LEH EHEC OEE HHO VES HEH ET OEE OD 9 409 ca 2 days, as Primary thoracal symptoms: rae. fis 2 ee Tonsillits acuta, Acute hemorrhagic Mediastinitis, Lymphatent tis haemorragica peribronohiale,. Peribronchiolitis acuta haemorrhegicas Severe Alveolitis and some bacterial dissemination. Primary abdominel symptoms: Lymphadenitis haemorrhagioa messntericae, Acute hemorrhagic ascites, | Hemorrhagic fungous swelling of interstitial walle ?. : Secondary metastatic chamges: ; - Heart with moderate degeneration and edema. “iver with “epatitis serosa III and some bacterial déssemiantion.. Kidney with slight G1 omerulo-nephrosis and some interstitials edema, ‘Pancreas with moderate degeneration. _ ‘Supra-renal gland with moderate congestion and diffuse hemorrhges in Z, reticularia, | Skin(r-thigh) with intense congestion, localised hemorrhages and diffuse wandering cells dissemination in subcutaneous tissues. - 10-368.5 days- : Primary thoracal aymptoms; Pn ea Pee ae Tonailiitis -haomorrhagico-catarrhalis acute, Acute hemorrhagic “ediastinitia, i Lymphadent tis Haemorrh: gica peribronchalia, Endobronchiolitis and Fersvronchiclitis ate Po Z , : a de 4 . A | Wil Slight diffuse Alveolitis, Primary abdominal symptoms: ; Lymphadenitis icaudeviunlesmucusaci aut by Acute hemorrhagic ascites, ; No remarkable changes of intestines. Secondary metastatic changes.: _ Heart with intense degeneration Liver with Hepatitis serosa II. Kidney with slight glomerulo-nephrosis and eltent tant: stitial edema. e - The Supra-renal gland with intense parnechymatous degenration = 4 and diffuse hemorrhages in cortical tissues, Brain with slight hemorrhages in menees: Skin with intense congestion, some .looalised hemorrhages and some round cell infiltration in subsutaneous tissues Ar-upper erm, Accordingly the primary changes of pernasal infection ave thoracal and abdominal’ symptoms , . Thoracal: Acute hemorrhagic exudative Mediastinitis, Aoute hemorrehgic inflammation of peribronchial lymph- : nodulus. rr te: “hemorshugls Peribronchitis and Peribronchiolitis, ae Hemorrhagic( -keucocytic) pneumonia,acino-lobular. °” gome times reagtive hemorrhagic Pleuritis. wns y Son Renpeee Rear ars plantings Abdominal: Acute hemorrhagic inflemmation of intestines, accompanied with fungous swelling of intestinal walle. Acute hemorrhgtc | inflamation of mesenterial Lymph -nodulus, Acute hemorrhagic ascites, ‘Then Anthrax bacilius,intruded metastatically into. various . organs,espeially liver, apleen, luge or some cutaneous _tlases eto, The most particular secondary symptoms ate as follows: veart withintense degeneration, sometimes accompanied with some | hemorrhagic reaction or interstitial edema, Liver with intense Hepatitis serosa, somotimen scoompanted: with | some hemorrhagic changes hemorrhages in central zone ‘of acunuses) or multiple miliary mecrosia(or knots) formation, ' Kidney with intense parenchymatous degeneration, dometimes _ Bcoompanied interstitial edema, , Spleen with splenitis infectiosa sadly onr so-called | Angio-folliculitis. heemorrhagico-exsudetiva. and: Fasciculitis 4 ps haemorrhagico-exsudativa, | f .2 Sutanéous tissues: I have investigated some metastatic localised erythema in 2 cases of all examined 10 cases, 5 ’ cs Soe 38 yours old. 8 ae ‘Entrance-port, Peroral infeotion, . Days of course, Ca 2 days.. ee — — ak eee I Tar ewenwnccnenenenruneae ena mm me a em mm mr a OS wom wn a Beart. ; Begeneratio myodardii, hortas.- No remarkable changes, nacrosooptoally. adalat aaa ee aonen 0 som eee , a : Tonsils Slight smfmucous congestion. sf oe o Pharyaa. - 4 No remarkable changes, macroscopically. | ve _ “ Bronohus. a No. remarkable changes. os 7 “lung. — - , “No remarkable changes. _ : pene m een meme nnn nanen anew enna ane © oe ow oes ee me we : : wren owen rene tnenm indie onwnn tie: ? ’ Liver, _ Hepatitis serosa II, with intense fatty degeneration, : v a Stomach. No ‘remarkable changes, , boas Snali-Inteat Intense hemorrhagie-leuscoytio titlanmatton ontth . fungous, selling of mucous "ner oe due to! deithrax- a infeotion. _ H oo ‘a 7 : Fe “LargeeIntest, Intense heno rrhagio-leuocoytio ‘inflammation ‘asin a fungous swelling of mucous” membrane, | due to. > Anthrax- Infection} me Ye mt | some , polar changes: : t seme places IEE), with coe OOS SSS ONO SSSA ee wens ere rr eee er a 4 - Spleen, Angio-folliculitis exsudativas. Spleno-Fasctoulitis Sy taxena. " Lymphenode, Intense follicular congestion and. lymphadenitis '“Mesenterial 3 ” oaseosa tubereulsa. i Weber mewenreeennenneten= a wie ain aed il ieuges decterowebacsuecheseuse, : eee , Aaa ve a Pancreas. missed, F ia a ? ‘ Supra-renal, Considerable atrophia.. ‘a ‘ d Ruining processes of Z. reticularis with some leucocytes in capillaries and gue 2, ‘some round cell infiltration in 2. rettoularis, = , “Tnyreotd, _ Struma colloides nodose levis and : - Sitght activated state. oPitattery Be xe “Mesticles | __ . &trophie testis Il. : Sere aT TRO wenn preg ’ ; 4 (Stasis pulmonum with sl ight Bronshiolitiss : ’ ’ Bpleeny =. | Angio-Follioulitis haemorrhagioo-exsudatives :. |. Spleno-Fascioulitis exsudativa ‘ Other organs. 28 years old, é Antrance ports. Per-oral infection, Days of course. oa 3 days, ‘ OO MON mE eee Wetec cen enwnn me mane mee wy ad ae : . ; ’ a "at Heart, ". No. vemarkable changes. 7 ee Aorta. = 4 Ko remarkable changes, macroscopically. U[nprterntecinccenenccsenencrnecnnnnnreenmnenaneneanentennnanctienlsninn | toe : aoe 7 , Tonal) ; e No remarkable changes, macroscopically, os : “Bronchus, = Slight edema and scald henorshages in submucous, tiesu ps ss Bronohilolas. Slight catarrh, _ _ : . . a "taing. : Stesis pulmonum with sume metastatio bactertal j weir "so! | Qdesemtnetion, a -_ : try coe B : 2 FAO ia aa Ae a rae ae pga kr ert coe ca oe “Biver. Hepatitis serosa III, with parthal ‘hemorrhage a. aan Ra central zone and mul tiple: miliary Hecrosis (: some ‘Lympho oytes-acoumulat ion). No remarkable changes, macroscopically. — Siatt-intoot, . Intense henorrhagic-leusocytio ‘Anflammtion’ rit ae i fungous swelling of mucous memebrane, due to 5 anthrax-infection. ‘Large-Intest. Intense. ‘henorrhegto-Leuscoy tte tnflamation with fungous: ‘svelling of mucous membrane, due te" Antiires~ Aafection.’ on Cae oe iecatatee’s an eae we oer e eta sien ee hata aha eaten tate tele Le ee es os sitent Giswecioons necens onaere in moute congestion with sme degenerative pee Nephrosis I with slight or intense interstitial edema. 6 wee wenn ennen een nrreene oman epecetenshy siaenteerharcckerens nae nne ‘ 7 ’ , . “Spleen, Snglo-Pollioulitis henorrhagioo-oxmudativas . . Spleno-Fasotoulitis, exsudativa, aa pee no ee ‘tpaphchoite . re ng ecg See ae ‘“‘Wesenterial: : Lymphadenitis hamorrhagico-necpoticans. : “'Perbronootal: Considerable follicular congestion, — Wh eit we cucssceperaemecea | weemcey ae sn epee Seeds aay” "Pancreas, Intense degeneration of parenchymatous cells. (some of them, vacuolar). 4 Oonsidersble obigeetion, ; 4 : ; Veouolar degeneration of Leland-os1lé.' Bite, kote tae Pituitary, Be co ee ee ee Pe, aie an oe xo The Testicles. a Gan not be. investigated mtorosooptoeliy. Mes lake . F Can not ‘be Anventagate miorosooptoalty. Coke 54, , : ca 25 years.d1d. & - Entrance-port. . Per-cuteneoys Ainfeotion.: | Days of course. | onfaays. peat? Heart.. Intense Getta soa: Atrophia and some interatitial ie Ba edema. ‘ dorta, - Ho remarkable changes. i Sel ae a = : Tonsil. : . No remarkable changes, macroscopically. 7 Pharynx, Slight oatarrh with some congestion end some round : : 5 cell infiltration in submucous tissues. : . Bromohus., Slight edema in mucous and submucous tissues. tang, et 7 _ Slight congestion, macroscopically. “ghey De a es eae ae re eee ee ay . Licer. Hos Hepatitis serosa 11-11, with some partial hemorrhages ° me ‘ in central zone of acinuses. Stomach, =, Slight catarrh, ; nk uali-Tntest, Blight catarrh-macroscopically. Large-Intests Almost normal, Safes een arene Pa nar erin eensnnrcenneeernrivcshinkerry teeranie rater “Kidney. ; Blight ‘Momeruloonepnrosia (glomerult in seconerattye form) ’ with slight polar changes. Nephrosis I with rather atrophic tubular epithe ions and at some places ome vacuolar degenoration, aes ar Nome Tar. Seka hone Pee ee ee tt 2 ; “Spleen, : Missed. . Lymph-nodes, _ Not investitigated mioroscopiceliy, Secchi c ES Sn Ouiocshn dence s case tere nakn we cscuue mad setae cansaceasuene seat thas . Cilvceia.. . . Slight congestion and slight degensration of | a parenchymatous oe11s and island-cells. a eipresrennl, : Considerable congestion and slight sme hemorrhagea es > i cobical tissues, . 4 “Vaouolar or honeycombed degenertion of. cortical cells, some Paling: process of ‘Ze sevineietis: , : ‘Thyreotd, _ Slight activated state. . a Struma celloides diffusa. | ok, | PA bultery Bia} a . ee Teticles, = | “Atrophia testisM © _eencnteanenanenecnneennnnenneennneenne Susese Se ae Braings sen aen feseee cme fhe Not invetstigated,. mioroacopically, 1 cnttrenennnnnnenaradnnnanatanannannnnnananwnanawenennnanmeenmnan nares ann Diffuse phloguonin, = aoe - " ntrencenport,, : 2) Daya or “course, or 7 Hearts ‘ Aorat, 3 ’ Beer te et tet ate Seen eee eee em ew ewe eee nee - Considerable degeneration. 35 years old. & ? Per-oral infection, ? 2. days. 2 “No remarkable changes, macroscopically. ‘a , ; jonsii. 7 - No ‘remarkable changes. macroscopically. ; | “Pharyng. Considerable congestion and some round cell infiltrat, : : Bronohus's: Considerable congestion (some leucocytes in : . : 7 . a capillaries) and slight edema in submucous tissues. “Tange Bronchiolitis catarrhalis. cor : . Edema et stasis pulmonume erage cis rea oar Sxse= ae aerials sa-sSe2 Semen nnn monte emer em dim Liver, _ Hepatisis serosa Tite: me ; Stomach, Considerable congetion in submuocus tissues. : Small«Intest. < Fungsus swelling of mucous membrane, with intense ; : hemorrhagic-leucocytic reaction. . lange-Intest, Considerable catarrh. om ww on eee ow es eh ow elt om in b am| a - Weiee, 3 1ngt0-7011 10 suai ion. so ee . Spleno-Fasoiculitis exsudativa. | Lymph-node. Mesontertal. Poricapsulitis hiaemorrhagica and considerable - follicular congestion, mm on Oe et OO on Oe Ow ew Ot Oe Ot Om OO a Oe oe om om om Ot Om ae Oe a MD Oe Oe om On Oe te me me (oe an 00 0h on cn Ot fas ten be ae oe ee oe 4 ry _ Panoreas. - Considerble congestion and slight edema. Considerable degeneration and some atrophia of paren- chymatous cells, Considerable degeneration. of island-oells,. Supra-renal. Considerable congestion and diffuse hemorrhages in cortical tissues with considerable degeneration. oi Thyreoid. In slight activated atated. ; Struma colloides diffusa levis, ‘Pituitary Bo = GP stioles, Atrophia testis m. rw ot ee ce ae on ae on ee ‘ Brain, _ , Considerable congestion (some , leucocytes in. Fy ee ee a nnn eee ee en ae Se ae ieee a ak me me nw i as - capillaries) and dl ight edema. PS OS tO Fy EO OD FS Be OD OD Oe Oe Om ED OD OD Om Os we ow Gm oe Om Ow ES Ot gn Ow ow om ws ae 0 ee cet re ey Om 0 MD Oe OD tae See Ow Ons Ow Oe Om ee Om Oe Om ‘ > . Skin. No remarkable changes. : ca 50, years old. % : Entrance-port. Per-oral infection, ‘ * dart. | eet - Aortas oa 6 pao if Bronohus. oo eee S i: ¥ Stasis levis and some bacterial dissemination, iy Days. of course.Days, | ae Oe Ok Oe ag ee Om ot ee em ke nee oe one a an Oe Oe ae ot on Os me ows ee om PO em me oe es ee, Degeneratto myocardii. Considerable congestion and some partial hemorrhages. F No remarkable changes, macroscopioally. ’ No remarkable changes, macroscopically. Intense congestion and some hemorrhages in submucous i a 4 1 - tissues, a _ gy Slight round cell(some of them, leucocyt1c)-acoumula- . : > tion in submucosttissues., '.NO remarkable changes, macroscopically, Bronchilolitis catarrhalis, — ’ (00 ae Of0 00 am tas ah Om fee tm Om Hn de om OD OP tee me Os Ow anew naaww a Oe ee an Or an om OO On om om em oP oe ae > ED OF Oe at OP OF me oe oe me om ge a a Livers ry ~ Stomach, | > - Small~Intest. e " LargerIntest,: Hepatitis serosa III-IV, with alight hemorrhages: in - " oentral gone of acinuses. ‘Slight cotarrhg and congiderable congestion in .sub= . : mee mucous tissues. eae Intense homorrhagio-leucocytic inflammation, due to ¥. ; : x Anthrax-infettion,. Slight congestion (can not be investigated macroscopically) oe te en as ee wa : le us Kidney. Slight Glomerulo-nephrosis (glomeruli in. acute . 5 : , congestion. Some of them in hyaline oirrhsosiss). : Nephrosis I (or III at some places), with consid@rable ae interstitial edema and some round cell acoumulation. oe Zs | a. pee ee re ee CSE eee we ee Spleen. Angio-follicultis haemorrhagico-exsuda titans. . : ; 2 . ; Spleno-fasciculitis oxaudativa, ‘ tmphatiode. . °. Panoreas. ’ ) Supra-renal, Thyreotd. oe Testioles. ‘ cS Peribronchial EES RUE ER eaorr r . _ Me senterial .Lymphadenitis haemo rrhagico-ne croticans and Periadenitis haemorrhagica, , 0 eo 8 Ot OD fee ln ON OO ES EN OD ED OE EDD MS HE EA IR ID a EO I aN An OE LEH OO Om ON OO aN ow oy | ’ “Slight congestion and some slight hemorrhages. : Slight degeneration of parenchymatous cells and telend F -oolls,. ’ ’ a, Partial hemorrhages in Z. glomrulosa and Z. , fasoloulartas ae Intense degeneration (ruining process} of z,. nebsoularees accomapanied with diffuse hemorrhages. Acute disfiguring (follicular collapse). . 7 ’ A4trophia testis I. : ~PLbudtary Bo poe Skin. . No remarkable changes. = “ ? oon Ct oa. 8G ~ yoars old, 3 . 3 ? : Entrance-port, Per-oral infection, : Days of course, 2 days. SOR BO KORO EE BE wee ee te om me On one On Gow oat ame Ooh am om oD Om ee Oe Oe me oe te oe ee cee eee Te) -~- > ‘Heart, | ° Slight degeneration Considerable atrophia and some si. : > a oa 4 interstitial edema. — . _Aortas - No remarkable changes, with some. stasis of peri- adventitial tissues. No remarkable changes, macroscopioally. Slight congestion and slight edema. Diffuse round oell (mainly plasma cells) accumulation and d ight vty hyperplasia of lynphatic apparatus in submucous tissues; ‘No remarkable changes, a Lung. — 7 _., Slight Congestion, macroscopically. _ een eee men en ewer era en cone eee mee een en eee menawennennnenenne ’ . . 7 . a2 ‘Laver, Hepatistis serosa TI-II. ~ Stomach, — Slight catarrh and considerable congestion in submucous tias , wes, | 7 Bmall-Intest. Intense hemorrhagio-leucooytio inflammation with : a fungous swelling of mucous memebrane, due to . Anthrax-infertion. , Large-Intest. . Gonsiderable catarrh. o : Perenrn oy . : : ped stg 0 00 io O80. FO OO DP OE OF On cee Be Om te Oe em 0 en a at nO OO Ont Ot 0 wD Oh wh Dey DM Sw eb ey et ea sO so Om Om Om om oO tm tn Oe ew ee” interstitial edema (Nephritis serosa). Spleen. Angio-Folliculitis haemorrhagioo-exsudativa, ; Spleno-Fuscioulitis exsudativa. ; Lymph-node. “4 ‘ a ’ ? ' , Kidney. Considerable Glomerulo-nephrosis (glomeruli in At ? ‘acute exudation), with considerable polar changes. Kephrosis I, with slight (at some places intense) Mesenterial. Lymphadenitis haemorrhagioa. macroscopically. ae Peribronchial: Considerable follicular congestion. . ee ee ere tenet ee erie Perera Pere eet Pere rt ret ne tet ret te ethene ree err, Pancreas. Considerable congestion and me perivascular round cell (some of them, Leucooytic) infiltration and t some edema. , i: | ? Cloudy swelling of parenchymatous cells. Intense congestion and considerable hyperplasia of Ao capillary endothel-cells 4a. island. cd y i Supra-renal. Atrophia. Vacuclar degeneration of parenchymatous eens : Multiple hemorrhages (with bioneoroic changes of adjacent parenchym. cells). ’ ? Some round cell accumlation in Z reticularis. ee ; a ‘Myreoid, Statical state... , F Strume colloides non-proliferativa. Pituitary. B. - : Testicles. ; _Atrophia testis m. eon eet ew er em een ene nn: 1 ‘ oon wow ar a me ow ows ewe we oe Os 0 nt on th nO 9 OO OW ow wn dw : Ban see pI Arig Sa AN : . I oe Yes i ree rage note ee ie Pee eo aa Op ore Seen sae ie ele ea : Se, ;: : ao eat sO cn OF 6 cat ams at x OP we PD Oa OS OD ME fa OOD OS GP OD OS Oa Um Oe Ue fin Ot PE Om ONO fe OD OS mt ON be Ore Oe OO a OD Or Om ee a EO Om wD OE OO 2 1 : a os as 4 Mth ‘Brain. No remarkable changes. eee ea ke oa es Oe Oar wm ee tae ee om On nm Bt We td OP ON OS OF OY OU OD OO OD WO OF Om BW ED OD Om om Ot om as On SH Ow Om de GRD OD em Ow tin OF OW tr Cw eH On wb Ow a ’ ’ : 7 i Skin. No romarkable changes. about 25 years old, 6 a _« Entrance-port. Per-oral infection. Days of course. _ about @ days. 0 ww wt ow ee 8 oe nt st ow me a an nae Om 0 ae Om om Om me mn oS a mE OD a rw mm me aah men YON ee ahedaal onm , ? Heart. Intense degeneration and consididerable stropht. * . ’ intense Ainterstitial edema and some myocytes. a a Rorta. Me No remarkable changes. i Sete se ae. eee a om oe on on Oo ia samme ane ded a he ae om oP oe oe Shekel ~ Tonsil. . No remarkable changes. Pharynxs | No remarkable changes. “4n submucous tissues. ra, . ’ Tung. . . Bronohiolitis catarrhalsis. Stasis et edema pulmonum and some bacterial . dissemination. ; . ; ‘Acinous-nodese tuberculosis. ; ' fungous swelling of mucous membrane, due to ‘ ? Anthrax-infection, Macroscopioally. ae Large-Intest. Catarrh and considerable congestion in submucous. “ « : i 2 1 t 7 eg, ed aeeueee in slg 4 4 ». Bronokius. Slight congestion and some leusocytes-dissemination pohege ; . : ee ee aie gee tot wo aa Gn eat am 100 WP Oh Gab OS a OR OD OD Om Liver. Hepatitis serosa Il.: : ean , vt : ’ Stomach. No remarkable changes. 4 Small-Intest. Intense hemorrhagic-lenoocytic inflammation with pe eR Ere er ere ren rere neet tet oT ry ett Dt 2 alti fe re aie pep tee TR ee a a : : Pe ; = : - 2% 7 1 fi Kidney. ee. Glomerulo-nephrosis (glomeruli in FOO Be acute stimulised state with some degenerative changes). : . Nephrosis I, with intense interstitial edema # a . ue nants i with slight polsr changese ; ales a a | ee ean ene enn nnn mene Rn ne mene nnn Maren an emma a mame mama erm em te ae | # 2? woe a Spleen, Angio-Folliculitis haemorrhagico-exudativa. : Ey : Spleno-Fasciculitis exaudativa. | . Lymphenode, cm Mesenterial : Lymphadentis haemorhagico-neoroticans. ‘:, Pancreas, i, a i re ‘ ’ ’ Supra-renal. Intense vacuolar degneration of cortical cells, aa Thyreoid.. . v Pituitary Be” - Testicle, Atropiria testis 11. : Soe Or a ae ee agar ae chara Wray OLE day Brain. - Slight stasis of meninges. ote ve Blight edema of brain, a Gereballum. - Gonsiderable congesion, slight hemorrhages and — / some edema in meninges and cerebellum, i ° Skin, No remarkable changes. 528 32. years old. & | Entranoce-port, Por-oral infection. : i Days of course. ca 2 days. ‘: Heart, intense degeneration and intense congestion, accompanie with slight hemorrhages. (many leucocytes in capillerie: . ’ ’ ’ Aorta. _ No remarkable changes. Tonsil. No remarkable change. — Pharynz, - No remarkable changes, macwoscopioally, : ae ’ . . Bronchiolus. No remarkable changes. Lung. . Acinous-nodose tuberculosis and no remarkable ohanges else. I lk al ed kate tenh taken ahee behead dle he tbo bake hed ha haketekakokakek hate telate tol akalek obetedukekulekokulekekel kiki tok et tt ’ 6 oi Liver. , Hepatits serosa III. e ? Stomach, , ; No remarkable changes, macroscopically. Small-Intest, Intense hemorrhagic~leucocytic inflenma tt on with “ fungous swelling of mucous membrane, due to ; Anthrax-infection, _ ; | Darge-Intest, .Catarrh and considerable oongeation in submucous tissues, . Reet Set ee ee ee Kidney; Slight Glomerulo-nephrosis (glomeruli in acute. e-- | \ congestion with some degenerative changes), with slight polar changes. Nephrosis I, with considerable interstitial edema nals slight cirrhosis of capillary walls in medullary tissues. atm Om 0 Oe Oe Wee Ot Oe Spt OF Oem am em Oo Fae OO Oe Ha Fa Om Om GD OF cy Ms Sam ome Om Cas my ms Os fa oO DUD On Hae Mm me er GD man Or Ole fn Od sD tm Ow Om Oe Oe oe bie Om Oe te ? . Spleens ’ . Lymph-node,. ‘mesenterial. Pancreas. 4 Supra-renal. thyreoid, 2 Pituitery B. Testicle. : cortical tissues, _ Atrophia testis |. ’ Angio-Folliculitis haemorrhatioco-exsudativa. Spleno-Fasciculitis exsudativa. Lymphadenitis haemorrhagico-neccoticans. Considerable congestion and some edema. “Atrophia and slight degeneration of parenohygatous Cells. , Considerable degeneration of island=cells, Partial hemorrhages and some degeneration of Vacuolar degeneration of medullary cells. Acute disfiguring (follicular collapse). mm On Om a Oa et Om ome tad De Mam es tw SY Lat we wh GD we Ot LED me ah Am db ea at ee a Om OD Om DO OD OF Se Om cae OE Hm Oe ce Oe OE OO ie ee Pat ae OP OS le te ’ a No remarkable changes, macroscopically, geo ee ent Oth 0m Oh co at Gd eat Om Ma OO On OF OD OD OE Mt OS oe ts Oe te oe Oe OT Oe ee ee KOM MMM we | a - Skin. ° No remarkable changes, macroscopically. ”- 3835 ca. 40 years old. $ a P * Enbrance-port, Per-oral rigeotion, a _ Days of course, ca, 3 days. Oe OOO ROT SOS TREE NE SS ROE SEMEN H RENAME EE ENE REECE EEN EEE mwa 2 ; ’ : Heart, : Intense degeneration and intense edema, 2 : 2 ; 1 Aorta. No remarkable changes. .Zonsil, Tonsillitis catarrhalis acuta, with i : a slight superficdia) ulcers and some swollen germinati centres of lymph-nodulus. S Blight congestion ( some bacterial masses in cepillart in follicular tissues, ? ‘Gonsidersble congestion in submucous tissues. OOO NEM MARNE RNS een ES a sees esessenes er eed as : : : ’ _Othér organs, Cannot be invetatigated microscopically. ? 388, | las , 27 years old. § a ’ ‘Entrance-port., Perenasal infection, 7 Days of course. about 8 days. eo ces es 0 0s OB Be tat ee OO Om a a BE ee om ow Om mm a A Oak OS OS EDD Om Ow OD OO OE ST ODD OT Om Oe OO Ge em a mm mY aH Or Fm EON om ON OD ED OD OO wets a . f a ’ . 7 Gheart. Intense degeneration. 4 Heart. Aorta. No remarkable changes and slight congestion of perl= edventitial tissues. were eemeedeeewecrwenennnneenne ween omen Pe te heel ‘+; . 93 Tonsil. fonsilaits haemorrhagico-oatarrhalis acuta. Ctarrh and some superficial ulcers, Remarkable swelling of germinative centres with aqme | FR | * swollen reticulum celis. and plenty leucocytes. Gonsiderable congestion, edema, multiple hemorrhages and some leucocytes-dissemination in follicular and , submucous tissues. 4 o Pharynxe Bronohus. _ Intense disturbances of mucous tissues with, considerable Ble ; oo congestion end some round cell infiltration. : _ Bronohdolus. Endobronchiolttis and Peribronchiolitis gragis with . Lywiphadenitis acuta in peribronchiolar tissues. - lang. : Blight Alveolitis and alveolar congestion. rare momen ene cere en ren nn ee een cn mmnewwnnnn Hanemenn nem ee Remeron nme ‘ 3 - ’ Bepatitis serosa 1-11, é ‘No remarkable changes, macroscopically. ot > , SS poeh _/ SmalleIntest, Atrophic glandular cells. No remarkable changes esle, a Large-Intest. No remarkable charges, macroscoplically. OE HS OE DOOR OEE Om Oe eee ie 4 7 7 ’ Spleen, Angio-Folliculitis haemorrhagico-exaudativa. ’ YA . Spleno-Fasoiculitis, exsudativa, , Lymphenode,. ; Mesenterial:s Lymphedenitis haemorrhagico-necroticans. Perfbroonhial: bymphadentis haemorrhagico-neoroticans. eee eee eo nm oe ee tt te ? Edney. Slight Glomerulo-nephrosis (glomeruli in acute stimulised form). ? Nephrosis I, with slight pinterstitial edema. ee meee were men mre mee were me eee meen meme een e enna n enn naam ee a 4 ‘> Prgorease ee ’ a ‘$upre-renal. Considerable congestion and some diffuse hemorrhages. ? é . Honeycombed degeneration in Z. fasciculata. ; Round cell accumulation in Z. glomerulosa. Bupra-renal. (2). Oonsiderable atrophia. ; ; 3 Intense vacuolar degeneration in Z. reticularis. Oonsiderable edema and diffuse hemorrhages in cortical - tissues. : Vacuolar degeneration of medullary cells, nage = myreota. yee poe. ae - : ~ Atworhts testis 1. a Brian. ; Cerebellum. ’ ae ne Slight congestion. Considerable congestion, slight pericapillar hemorrhages and edema in meninges and cerebellum. upper arm (r) ;: Intense congestion, naccotic ruins of capillary walls, some localised hemorrhages and some round 0e11(some of them, leucocytic) infiltration in submucous tissues, a 389, Entrance-port. . ? Days of course. Tonsil. : > Pharynx. :. Bronchus and . 7 ’ - Bronchiolus,. Lung. 20 as am ote oe om Ot Gn as om aD ams em Liver. a Stomach. 4 Small-intest,. Large-iIntest. i a, i oo a oem oe om em ew emis “> Kidney. - Spleen. eee ee ee 7 Ca 25 years old, $ Per-nasal infection, ? 3 days. Considerable degeneration, No remarkable changes. No remarkable changes, macroscopically. Can not be invetstigated macroscopically. Bronchitis and Bronchiolitis catarrhalis, with intense Peribronchiolitis. ; Slight Alveolitis or Slight pulmonal edema. Ol Rel take tel Sate tel! are mem Oe ae tO ee tn tat cae ae me nt fa Ut OO dS nt em ee + (can not be investigated microscopically. ) No remarkable changes, macroscopically. Considerable catarrh. Catarrh and considerable congestion in Bubmucous @ tissues, * (can not be investigated minroscopically). mas sed . OO a Oe eee ee tae OO oe ae Oe Om OO PO Om UD nO Or a ae ee Pe OS ee Oe Oat Oi A et OD OP ne Oe fd ee me te Ow Oe tt 4 Lyph-nodiius, Considerable cdigestion and some hemorrhages in ‘Mesenteriel t , Follicular tissues. 57 _. Peribronchial : Lymphadentis haemorrhagico-neoroticans gravis totialt aa eee e : : : 7 ea a ‘ hy _ i Pancreas. - ‘Suprarénal., _ Considerablw atrophia and severe degeneration of parenchymatous cells. Considerable edema and diffuse hemorrhages in 2. "reticularis. Brains : 4 Ceredéllum. 2 25 years old. 3 a Per-nasal infection. 2 's a. , Intense degeneration and some congestion. . No remarkable changes and slight congestion of perte 5 es, adventitial tissues. rae 7 Sasa Sees UA cane ee a - . | Tonsil, Tonsillitis acuta haemorrhagica. ; 2s fe ‘ Bio-necrotic swelling of mucous membrane, “ Intense congestion in follicular and perifolliculer | |. ‘ tissues. Some hemorrhages in perifollicular tissues, Remarkable swelling of germinative centres with ey ? : some localised hemorrhagic places. | ? Intense congestion in submucous tissues. Se r ? a Pita 5 cs Bronohiolus. Bronchiolitis acuta catarrhalis, ee oo Yang. Blight Alveolitis and slight Stasis et edema pulmonun. . ibe . ; 3 : a Hemorrhagio-necrotic changes at some places. © ee eoeene Sewer eno m ewww ne -~ lee ell eee hotel att TR “8 . . i ? Sat gt _ Leber. - can not be investigated microsodpically. © Stomach, No remarkable changes. : ? : , 2 Small-Intest. Considerable catarrh, a? . ? . ‘. Large. Intest. Catarrh and considerable congestion in submucous. baek 4 : + cae ae tissues. ee oan Kidney, can not be invest ga iene Spleen, ‘ Angio-Folliculitis haemo rrhagico-exsudativm, Spleno-Fasoiclutis exsudativa. -“" Lymphenode, ’ . “> Mesenterfal. Lymphadenitis haemorrhagico-necroticans, re al 2 “9 ’ ’ ‘Peribronohial 3 Lymphadenitis hesmorrhagica-graviss t.°c. ton, cae joerenenegteerarnrernennannnennnnannnnanncnnnsananancnrannanmnanncanan cs : Ponoréas. F ou ; Supra-renal. Multiple miliary absesses. : et Diffuse necrosis in Z. fasciculata and Z,.reticularis, a. : oe |, Edema in medullary tissues, Pituitary B. eo, ce ye ee Testicle, | _Atwephia-testzs. — | lela 2 Den eee See ee Eee a eo oe a Braing. bog oe . ae 7 ae Skin. Pe No remarkable changes. ‘ ° 393. Entrance-port. Per-nasal infection. a 4 » Days of course. v2 eS MR a a ee ee es Ss - i eee eee “Se ake Oy 34 years. old,’ 4 days. oe nn dee nna nn ene ween er eee nemo nnn mene worn wane ee eee ee ey ate > Intense Hegeneration and considerable atrophiy.. S ’ Heart. Intense congestion, slight hemorrhages and edema. ves Aorte,. Slight congestion of vasa vasorun in medias ‘ op Tonstly Pharynxs . Bronchiolus. tung. % Liver, Stomach. > Smalle-Intestin, -= " 3 rd . ‘Pleuritis exsudative tubercnlosa. No remarkable changes. Can not be invetstigated micorocaopically. f 7 - . ‘ : ; Bronchiolitis catarrhalis. + Stasis, edema and d@ ight Alvéolitis. 0 we OD DO OE ee OS Oe om OP 0 Om ae BD FOF OS Oe Be Om Oe BO me Om he OS Oe Oe ab Oe Oe OS Bae Om Om Om On OD Oe Ome Ome Om OD OS ED OD ED OD OE OF,0F 92 Om OD Om we ON Ot Oy Oe Oe Oe tn a Hepatitis serosa I-III. $ ige ? . Large-Intest, ~~ a as eas Segre orurg nee tere ag ea Kidney. . Considerable Glomerulo-nephrosis (glomem 14 in acute. . atimlised state), with slight polar changes. Nephrosis I with (or IIT at someplaces), with a “considerable interstitial edema. - , . @ Spleens | Angio-Folliculitis, haemarzhagioo-exsudativa, Po ; Bpleno-Fasofoluitis oO ob “mphenode. - , ee Mesenterials Lymphandentis haemorrhagico-neobo tioans. " Peribronchial:Lymphadenitis haemorrhegica. Oe ee eee el ee ae nen awana ams ow > Panoress. | Gonsiderable congestion. Le ‘9 7 Gloudy swolling of parenchymatous cella and islandcells. te Supra-renal. _, Intense degeneration (desolative decay) of paren- fot a : 4 rd - ’ chymatous cells. esp. bionecotic changes in Z. fasocioculta, Koneycombed degeneration or vacuolar degeneration . - of medullary oellsa, 7 - Intense | edema of capillary walls in medullayry we : a, tissues. , . a * Mhyreodd. , . Aoute disfiguring (followlar collapse). ‘ - Rabattery Be, Tasticles. Abropha ‘testisDL, wa pe : om - Skin. - Yo remarkable changes. 306, e . + Entranoe-port.. Per-nasal. infection, we , , ’ + a * Days of course, 3 days. '. Heart. Considerable degeneration and intense atrophye Intense edema and some leucocytes in capillaries. . ’. "Aorta, ss»: ‘No. remarkable changes. “ ipwita veld uucneuddoetae detubastecemscesnnwancacccalscksaunpaesedeeaacce “1 Laver. Hepatitisserosa II-III, with some pertoapillary Leucocytes-accumulation (initial stage of miliary. ~~ eo / necrosis). 5 : ‘ : = “4 | Stomach, j ‘Blight edema. $mall-Intest. Atrophio glendular cells(microscopically). coms ; : ? Targe-thtest. _ Almost normal (microscopically). bititimtenep enn nnanannnen an nn: eer (2 OO Oe en ot nn a ten ws anew "tl : mae: ee Blight Glomeurlo-nophrosis (glomerult in degenerative aa “ Saas rat nn fot), with slight polar changes. — : ee T (or at some places III), with considerable “ aiteta Prt ‘pe Leteocytes in capillaries, see seelnsinnaibnauilngubicdaimnnensnarmeecncenenertnbnentrncnet : “? pet a : ‘Spleen. : : smieoeds ‘Lymph-node. i . ALD yeahs dt Meschterial ay Wo ‘remarkable changes. ¢ " Pertbronchtel Lymphadont tis hhaenorrhagico gravis. pe ot ae OF ten O00 om Ga on em a : trea bs : Begin ai i le tee er ee te “{ Monsil, —» Yonsillits acuta. CORR, oS Intense edema, localised superficial ulcers and : ee z! 2 .catarrh of mucous membrane. ; ‘Intense congestion (some bacterial masses) and 7 ? as i intense edema in follicular tlasues, Swollen gerinative centres, . : ’ 4 _-> Bronchfolus, Bronohiliolitis catarrhalis. ; : Lung... Diffuse Alveolitis, atelectasis at someplaces. ? oo He - gubpleural localised exudative ~hemorrhagic places. &, Pancreas. : - ’ @ “. Supra-renal, Intense atrophy. + - me : ¢ Intense Degeneration and partial necrosis in Z. a 7 ; fascloulata. . : (2) Thyreotd.' . Acute disfiguring(follioular collapse). ae oar . Some bacterial masses in capillaries, : - _' Patudtery B. ‘oa. festicle. — Atrephia testis 111. aera sca aaa se eae ee vee a wet eee ewe meen ewe meena * Brain. No remarkable changes. ee Skin. ‘Wo remarkable changes, o 397, ee ee 27 years old. 9. ’ ' ‘Entrance-port, Per-nasal infection. Days of course. 4 days. Heart. Slight degeneration. Considerable interstitial edema and considerable ' ? hemorrhages in epicardial tissues. 4 Aorta, No remarkable changes, Tonsil. Tonsillitis acuta. Considerable congestion and edema in follicular tissues, ; Remarkable swelling of germinasive centres. Considerable congestion end slight hemorrhages in submucous tissues. a 2 -- Pharynx. No remarkable changes. a “2 >, Bronchus. Considerable edema in submucous tissues. ¢ 4 Lung. Bronchiolitis catarrhalis. ’ Slight stasis pulmonum and diffuse Alveolitis. 2 bas Ont Oat Oh Oot OD Ge Sim OR RD OD OD Get Oe Be SE 0 Em Em OS mb ED Oe Oe Oe Oe ES SS OD Om Fe om Oe Om Om Em Om OD OF OS E> Be Oe Ot OD Om Om Om OD ODO Om OD OD OU OR ON ms Oe Oe ON Om oD Oe ee =a ’ ’ Liver. Hepatitis serosa III, with multiple submilary ; Imots with plenty of lymphocytes, Stomach, , Ro remarkable changes. ; Snall-Intest, ; Slight bien aha paeiacticerene Largestateat. ‘ pe ae FU gestion. a - KAdney, Can not be investigated microscopically. 3 oe Oe 00 Om Oe ow ws et me ee ee Se we Beemer rw ewe Oe Be wee = on ow o> as oe om a oe ae > 7 ar a Spleen, "- Angio-Polliculitis exsudativa.., Spleno-Fnscioulitis exsudativa. Lymphnodes, ie hg Me wenterials Lymphadeni tis. catarrhalis, " Peribsodehhatze: Lymphadenitis haemorrhagico-necroeticans totalia, a pe Pen ee : ts : (5 0 8 a ey ae ek Ot oon Om Oe Om en Oe OD PP OP Ok OW me OD On om Cwm mewe - te OF Oe 8 me oe ow me > Oe OD Om Oe Oe om ED ee Ot Oe fm Oe On tt Ot . Panoreas. og % brs / ; ce Supra-renal, Vaovnolar or honeycombed degeneration, esp, in 2. re . fasotoulate. - Intense edema, slight perivascular leucocytes= : accumula t. on and diffuse hemorrhages in, Ze peeibdlasiec: ek _ Gonsiderable edema in medullary eviee' a Thyreoid, ) . . | * PAtudtary Bw ; : Testicle, _Atrophia testisil. > ’ ~Braine. - ' No remarkable. changes, Cee Rem mammmm mm ee ee ae oe a a Opn 8m Oe Oat Be ae Om Oe Oe Oe Oe We OS Oe Oe we OP Om Om Oe 9 ae Om DO OO bw OD Om Ow OD aD OD OD On OD ee va 3 > eo i F Bin, No remarkable changes. 399, SS 26 years old, 3 a Entranoe-port. Per-nasal infection. ; Days of course, 35 days. -. Heart. Considerable degeneration, e Considerable edema and some hemorrhages. : ? j Some Myooytes, j * sorta, - No remarkable changes, macroscopically. . esearanataiaseaaiaiaiaindalaiatebriabahe mew ewe ee aa aaa aia aati cn Tonsil, - Tonsillitis acuta. -Intese congestion in follicular and perifollioular. ‘tissues. ; Swelling of germinative centras with some leucocytes: ’ . . not end. someplasma-cells, a oo ‘Intend congestion and ‘some plasma cell dissemina- , tion in subnucous tisues, - Bronohiolus, No remarkable changes. ; “Tange © , : Patial slight congestion and partial ateloctasis, oe ? Livers _| -Hepatitis serosa III-Iv. Remarkable congestion, remarkable exudative change and multiple hemorrhages in acinus. . Almost normal, renerble—chages, ey , a . | . awa. Small intestine. A¥rophic glandular cells(microscopically). Large intestine. Catarrh and considerable congestion in submucous tissues. Kidney. Slight Glomerulo-nephrosis (glomeruli in acute stdimulised state with some bacterial and fibri- nous masses in gromerular dope) with slight polar changes. ; Nephrosis l,with considerable interstibial edema and sowe erythrocytes-cylinders in tublar spaces. Spleen. | Angio-Folliculitis haemorrhagico~exsudativa. %, Spleno-Fasciculitis haemorrhagico~exsudativa. Lymphnode. . ' Mesenterials Lymphadenitis acutea haenorrhagica. ee Pertbronchials Lymphadenitis haemorrhagico~necroticans. i A am es We 0 oe a ED tnt SOD TAS TAD Ae RD Os A GN eb SID EID GD Hm Ga em onh Oi OO OR fe GI at ty A OD nD OH oe On Oi Om Om Oe Ow Ow, 0D me ER te Ow am OO oe ne Oe ee on ow mm -. \. } Supra-reanl. ' Considerable vacuolar degeneration, and at some places honeycombed edegeneration ( in Z. retviculfis). o o Intesne hemorrhages in Z. reticularts. ca ? . Thyreoid. Acute disfiguring (follicular colapsea). “Pituitary B. - . Festioles,. Atrophia testis. - Brain, - | Siein. No remarkable changes. Henne ee nnn nc ee yeaa etme hn om 400. 7 32. years old. § ’ Entrance-port, Pernasal infection. - Days of course. 3 days. Heart. . Considerable degeneration and some mesenchymal : reactions. , Aorta. No remarkable changes, macroscopically. Tosti. -- Pharynx.’ -- ; . Bronchus,. Consideable congestion and somé edema in submucous tissies. “ co Some leucocytes in capillaries.’ Bronchus. | Intese Bronchiloitis catarralis. , _ Lungs . Mulliple acinous hemorrhagic places, . Atelectasis at some places. Liver. Hepatitis serosa II, with intense congestion at Glisson's ; capsules, ; " Stomach. ; Can not be investigated, microscopically. - Small-Intest. * ‘ "- Large-Intest. " “8 sor ere etme cr menen enw nr mmm nn nnn nnn nnn nn naman mennn nana nnn ann neneenn nee cen Kidney, " eee ene mewn e rece n enw nw en nen ne ene ee enna newer een wrnerewnne ewe remwn enn ee tees PT oe sls a an toe ‘ "Spleen. Angio-Folliculitis exsudativa. Spleno-Fasciculitis exsudativa. ; _ Lymph-node. ’ Mesenterial: Periladenitis haemorrhagica, _Pollicuclar congestion. Perlibronchial:Lymphadenitis haemorrhagico-necrosticans. OO Oe em om Oe Om Oe OF One 0 ee ee ee en OO ETE SE MOSER OES OS EES EE ee . @ Z Pancreas. Stasia and slight degeneration of parenchym,ocells. ‘Supra-renal. Considerable clouding, vacuolar or honeycombed degeneration of cortical cells. ? ’ Intense edema and diffuse hemorrhages in Z. reticularis. ‘ Thyreoid. “< - Pituitary B. -- : Testicles, — Brain. -- Skin. No remarkable changes. RR A EP st er re re 37 years old. $ Entrance-potr. Per-nasal infedtion. ’ ’ - Days of course, - Bronchiolus. Lung. 2 days. Considerable degeneration (some places with vbasophilio . degeneration). Some mesenchymal reations,. No remarkable changes. No remarkable changes. Slight diffuse Alveolitis. fe OF OR Ae ON Ne OO OOD ON em eee ee ee ee Liver. Stomach, » Small«Intest. a Larga-Intest. , _ Lymph-node. Mesenterial Peribronchial 3 Lymphadenitis haemorrhagico-neoroticans. 0 a OO mt met om aoe Om Om or ws im oe toe om ew ee ewwenne Oe we ewww wn mewn wee ewe meme mee ee we wee, ry 4 “ ‘Thyreoid. Can not be investigated microscopically. No remarkable changes. Slight catarrh, microscopically. Slight catarrh, microscopically. Anglo-Folliculitis haemorrhagico~exsudativa. Spleno-Fasciculitis exsudativa. > Lymphadeniis haemorrhagico-purulenta. a Follicular collapse with Struma parenchymatoua levis. a ee : 54 years old. 3 ““Entranoce-port, Per-nassal infection. ‘Days of course. 5 days. . Heart. = ' Some degeneration. Some Endoarteritis with some round ° . c@1l accumulation in tntima,. ¢ a Aorta. No remarkable changes. OO a Ye A OO 8 tw OY at ene OO Sry ak HO Wee a nO ot ee tn HOF wn bt ew ww ee em ot eekekkol ~~ oo ? ’ Tonsil. Tonsillitis acuta, with Intense bionecrotic swelling and multiple diffuse Slee superficial ulcers. Intense congestion and edema tows swolling of follicular tissues with bionecrotic swelling of germinative centres, Intense congestion and edematous swelling of sub= mucous tissues, ’ Pharynx. is '-: Bronohus, Intense congestion (with some leucocytes in capilla~ ries) and intense edema in submuous tissues. Peribronchiolitis with some congestion and some rf ; Sanoeeiagea: . ; ° Lung. Bronchiolitis catarrhalis, Acino-lobular pneumonia (hemorrhagic~leucocytic) ee dd ee rt rr Seararers 617 OO as 0 ee Om OO ee Oe On Om Oe Oe ee OO OO OP ee we a ee - ‘ ie 3 ¥ + Sey Soa ‘Liver. Hepatitis PP ene bactllus in capillaries, . Stomach. No remarkanle changes, macroscopically, ’ Small-Intest, Atrophic glandular cells. ’ " Large-Intest. Catarrh and considerable congestion in submucous tissues, . Fee On eh RE SS Cm ES ey OS mm OS OS Oh oe as a OT et OP fe OS me Be Oe OD Oe OOS one tee Se Oe Ot me OY mE SO Os Oe BD On Oe Oe Oe Oe Oe Ob OD oe on Kidney. Slight Glomerulo-nephrosia (glomeruli in stimulised | state with some bacterial and tibfoious masses in glome-~ ‘ A rular loops), with d ight polar changes. ,Nephrosis I (or III at some places) with considerable : interstitial edema. : Spleen. ” gnglo-Follieulitss. . . ‘SptenowFascrouritts ’ _ Lymphe-node, : Mesenterial : Lymphadenitis hdgmberhaclecépodsa tiasiae ? Peri-bronchial t Lymphaadenétis haemorrhagico=neoroticans. Pancreas. Considerable congestion and edema. ‘Considerable degeneration of parenchymatous cells and a island-cells, ". Supra-renal. - ‘ Thyreoid. , Aoute disf4 guring (follicular collapse). Pituitary Be = Testicles. _ Atrophia testis HI, ‘Brain. me POON ORO Re mM ee eee eee meee nee ewe 69. p : ; ‘ er) amen a meee naam nenaonoms _ |. ‘ : cae : a : Z : é ee ’ ? 7 ; Skin. No remarkable changes. A CI LL EC PS - SPthSUaDS eeve | ' ’ ; ’ , 1 j oy * ry i ive ‘ t i ae Fe yet: ie aa os "404. ocr : 27 years old. 3 . ¢ ‘Entrance-port,. Per-nasal infection. a a s - rf . Days of course. \ 3 days. Heart. Some degneration. and intesne edema. 3 Some Histiocytes. e , 2 | Aortas ae: No remarkable changes. _ A OF a Oar a on 8 Om OD Se OF OF Gem SO OE OD in OD Oe De Om ED Om mS ae tee me me Se me we Oe OO es ON Oe Om Oe Se Oe Oe oO OS Om On et et Hs 0 OD me wm oe om os ay te on sO tn ‘ ‘ t “Qonsil. | - 7 SY ode ; ".Bronchiolus. © No remarkable changes. “Tung. «sss Stasis pumonum, Slight Alveolitis and atelectasis, / Liver, Hepatitis serosa III-Iv. “Stomach. © No remarkable changes, macroscopically ” Suill-Intest. Considerable congestion and edema in submuoceres. tissues, : nee. : pene ’ . _'. mloroscopieally. . /-Large-Intest. . Considerable congestion and edema in submuocus tissues, some perivascular leucocytes accumulation, |, OAM RO ON Ewe ETE NaemneEw een omen emewemenen Oe ee oe ee 0 te eo om te ’ ae ae ” Kidney. Slight Glomerulo-nephrosis with & ight polar changes. ©. - Nephrosia I (or III at some places), with 7 : --—- @onsiderable edema and some round cell infiltration, | 7 ia a a a ae a cia ; , a : Spleen. “missed. : Lymph-node,. Mesenterial: Lymphadenitis haemorrhagioa,. Perinronchial: Lymphadenitis catarrhalis levie and ; Peri-adenitis gravis, with intense congestion , hemorrhages and edema. e Entrance-port, ‘Days of course, Heart, Aorta. er eee a . Tonsil, ’ Lung. 4 27 years ola, 3 Per-nasal infection, o 3 days. Intense degeneration, intense atrophy and some e dema e No remarkable changes. Tonsillistis catarrhalis acuta. : Catarrh, slight superficial ulcers, Slight congestion and edema of follicular tissues. Intense serlling of germinative centres and slight congestion in submuosus tissues. Multifocal acino~lobular exudative-hemorrhagio . pneumonia with intense atelectasis at some Places, — 20 Pw Oe Oar Ob ten 0 OD OP OS Os in tad Hm ne Ot ae WO OD GRD Mr ts One OD Ow Om oe 2 OO SE Oem CD A hey CaP CaO Et SS ED OP fn Sh OD Fs a DP Gem ed Hu eb Fit WD OD Ga OS Df em wm e Liver. | Stomach, Small-Intest, , ..Large-Intest. Hepatitis serosa TI-111, ; No remarkable changes, macroscopically. ; Can not be investigated, microscopically. Considerable congestion and edema, Slightperivasculat leucocytes accumulation . leah teh tetettetete tet tt tT tt tt weeeeomoanae ROR OBS Rew EM me me ae OO 0 On Om Oe OP oe OD Oe as om Oe EO an em en Oe On ? . Spleen. . ? é Angio-Folliculitis., haemorrhagico-exsudativa. Spleno-Fasciculitis. exisudativa. iy 4 a ; Lymph-node. Mesonterial: Lymphadentis catarrhalis acuta with dlight . . pericapsular hemorrhages. Peribronchial: Lymphadeniiis catarrhalis. | : ' Kidney. . Blight Glomeruolenephrosis with dlight polar , changes. Nephrosis I, with intense vacuolar degeneration of some tubular epitheliuma and intense edema. _ ‘Panoreas. . . Supra-renal. Vacuolar or honeycombed degeneration, esp. in Z : fasciculata. Diffuse hemorrhages in cortical tissuese Thyreoid. , In statical siate. : Pituitary Be - ; ' Teaticle. Atrophia testist. ‘Brain. - _ Skin. | ' Wo remarkable changes. a ree LS i St se eS SHER 406. $1 Years old. Entrance port. Per-nasal infection. Days of course. — ca 2 days. ; Lung. Slight congestion and edema. Liver. - Hepatitis serosa ll-11l. , ot Stomach. No remarkable chamges« Large intest. No r&markable changes. ene Gab nem at $0 Ah eat 8 Ab GS 2m Oe Hak om eS nn ad OD ED RE On om cle ee Om et ere roel ee ee ee ees _Thyreoid. In slight activated state. Testicle. Atrophia 111. eh ae em mn an hn 0 a ee Od Ra ne an om en mw a a Oe me dt an kt DE OO EN Oh Ro OED es AO OP EG ee dO HOP ne Om Ot Otherorgans .« Can not be investigated,microd@copically. , ; Entrance~port. Per-nasal infection. : - Days: of course. 3 days. = - ‘Hoart. Intense degeneration and atrophiy. . ae a | ; _ Some interstitial edema. ; ie Aorta. ‘No remarkeble changes and stasis of pertadventitial oe go tissues. ae | | A Bronchioius. ’ : lung. : ‘Liver. - a > SmalleInteat, 4 aan ee a eer et Tet rt 28 years old. 2 Tonsillitis haemorrhagica acuta. Intense congestion in follciomlar and peri- . 4 follicular tissues and slight hyperplasia of 7 . geriminative centres with some swollen retioulum }: 7 4 fibres, . _ Intense congestion and diffuse hemorhages in ‘submucous tissues. ; Bronchiolitis catarrhalis. 8tasis.pulmonum, . Hepatitis serosa III, with multiple miliary. necrosis and so-called net-necrosis-like- ohangepy ' Duodenitis haemorrhagioa with diffuse hemorrhages. '4n submucous &Sissues and some hemorrhages in. eeu submucous be Fase Enteritis haemorrhagico-exsudativa with epme ’ Large-iIntest. Chabal ell teed fot tot th tet tot tt Te ae NT rd ? Spleen, é Lymph-node,. ‘Me senterial ry _Peribronohial : | Oo om a ON ae Ot Ot we 08 Om On OD tm Oe Om Oe om Oe mh OF > Hat > OD OE ON OD wt OO Se OO Ob OF OS Oe OS Oe aD OO OS OS Oe OS OO OE OD OF Oo OF TO Om Oe OS HY Oe Om OS nw Ow a q ’ Kidney. | Ce Oe om 0 OF OS Od OF On Om Am Om a On Om bet HD em Ot we OF oe Om Oe OD OD OD OD OS OD OD On OD OD OP ED OD Om OD On Ow OS a DT De oe ow ae eae a tem on fd ats em ms on mn Oe om am , -, Panoreas. > -Supra-renal. ’ » Thyreoid. | pituitary By Bestiole. “gun tan am at fe LO gD Ow ww we om Ow OF we Oo eo eS ene nenoane Cem een we wee eres Re meme ae oF : atin a Angio-Folliculitis haemorrhagico~exsudativa. ? fungous swelling of mucous membrane. Almost normal, macroscopically. dae Spleno-Fasciculitis exsudativa. Lymphadenitis haemorrhagico-purulenta and Periadenitis haemorrhagico-purulenta. Lymphadenitis haemorrhagica. Slight Glomerulo-nephrosis with slight polar changes. Nephrosis I with considerable edema. ? . Considerable congestion and edema.. Atrophia and cloudy swelling (sometimes Rae vacuolar) degeneration of. parenchymatous celle. Mousycombed: degeneration, esp. in Z. ‘fascioulal ta, Some localised hemorrhages and perifoocal ; leucocytes scoumulation in Z. reticularis, Acute disfiguring (follicular collapse). 2 Atrophia testisII. ; Brain. - ? Skin, No remarkable changes. 7 Entrance port,. ¢ Days: of course. OO Oe Ome eat Oat aot Om FO aad ae BD 0 SD OF Ee OD Oe ES OS Oe OS we Om Om OO Oe Oe FS Oe OF Ow OF Oe Oe Om Om Om OF OP OS OF ED OF OD nO Ot mt aD OO A OY oe OD Aorta. {2 Oe ee oe Oem Oe cae OF OP OP EF OO OS OD GD Oe OD Oe Ge On OP Oem 0 Om Oe Oe Oe POS OF OD Om OF OD OF OO ee Oe ee YS EEN OS OT Mn Oe aD eA eH ER OR om mE Om OD oF Torsil o Bronchus, ‘Intense congation and edema in peribronchial tissues, ? . Severe Alveolitis and edematous swelling of pleura, 32 years old. 3 Perenasal infection. ? 2 days e Considerable degeneration, some atrophia and edema. . No remarkable changes. 7 Slight congestion of periadventitial tissues, Tonsillitis acuta. Intense edema and some leucocytes-acoumulation in mucous epitheliums. Intense congestion and edema in follicular and perifollicular tissues. ‘ Some swollen germinative centres. Intense congestion and edema and some round cell accumulation in submucous tissues. | Intense congestion (some bacterial masses in capillaries), considerable edema and some leucocytes dissemination in submucous tissues, Bronchiolitis catarralis. Some bacterial dissemination in alveoli, - Lot , mene ee ll enh. ‘ 4 -. Liver. Hepatitis serosa II-II1, with some bacterial masses 4n capillaries. a a Stomach. No remarkable changes. ’ ’ Small-Intest. No remarkable changes, microscopically. Large-Intest. Catarrh. . ae am ct ae atm a eee DS Oat ce te EN ae OS tee SF ee Se Ok Sab a ee mh NN OT AD DD OD OD OD OD Om Oe Oe Os SD OO Oe Om Se OD OE me ew ED On oD Oe De a . é “KAdney. Slight Glomeruloenephrosis with slight polar changes. Nephrosia I with considerable edema and some round cell aocumulation. a Miliary cirrhotic portion in cortical tissues. Pen Sa SOE Se See NODES eS Se em name wee ae ee a am Oy Ome ae Pa a ee nt PO Oe Om nO a , Speen. . angio-follioulitis exsudativa, Spleno-Fasciculitis exsudativa. . ’ . lymph-nod6s, — / <> Yesenterials Lymphadenitis -haemorrhagica. 2 ’ - Pertbronchial: Lymphadenitits haemorrhagico-purulenta. eeeroe edema nen enunaninnusuecnnenedvumenenenencenenunnenerseecteres | Pancreas. ' | Edema. Parenchymatous degeneration. - . ; Vaouolar degneration of i1sland-celis, ; _ Supra-renal. Considerable congestion and diffuse hemorrhages in Z reticularis. Some atrophy. ; Tatense edema and desolative degeneration of parenchymatous . gels. 7 Thyreotd, — Ea activated state. phtuttary Be - , ti | | | | : ae , oe. i . i é a “‘Mestioles, | Atrophia testisi. : 7 eee Brain. : DOO EG ey Oe ee ae EN tie ae eaueeee nan anaen es ‘ ean wmm* Skin. Intense congestion, localised hemorrhages and diffuse wandering cells (some of them, leucocytic)-dissemination | 4n suboutaneoud tissues. GO es a 410. ee. 27. years old. ae aoe. rf a 3 Entrance-port, Por-nasal infection. Days of course. 3 days. Poder rmeccnntennnewancssen See ceetrrarsn ses Senesaceecesceereserene=secee Heart. Considerable degeneration. Atrophia and interstitial edema. Some Myocytes. Aorta. _ No remarkable changes, macroscopically. Tonsil, Can not be investigated micrescopically. Bronchiolus, Bronchiolitis catarrhalis. Lung... Slight aiffuse Alveolitis. Liver. Hepatitis serosa II-III, with partial hemorrhages in , central zone of acinuses. ; Stomach. © Some lymphocytes in Glisson's capsule. Pacudo-biliary ttact Oonsiderale congestion in submucoaus tissues. - &mall-Intest, Gan not be investigated microscopically. Darge-Intest. Slight catarrh. Kidney, - a ae a aT a aSct2eaeneae eeeneaee Smee renereoawe ee ye og ey Spleen. Anglo-Folliculitis haemorrhagico-exsudativa, Spleno-Fasciculitis exsudativa. Lymph-node. Oan not be investigated microscopically. Oe ew Ome ee BEE eee meee Rama ewe 2 at ae ot OS Oe OD aD OS OR me Om Ou Oe Ow OD em OD a me OD Om Oe Om Un OP ONO OD Oe OO 3 = _ Supra-renal. Vacuolar degeneration and pabial necrosis in reticularis, Plenty loucocytes in cepillaries (with some myelocytes and some bacillus). ny | 2, 7 28 years old. 3 : ’ Entrance-pert.. Pernasal infection. . ’ a Days of course. 4 days. Heart. Considerable degeneration and atrophia. ; Some mesenchymal reactions. Some Myocytes. », Aorta. No remarkable changes, macroscopically, — ~ Liver. _ Hepatitis serosa II-III. Stomach. No remarkable changes, macroscopically. ° Smati-Intest;—Gen-not—be—investigeted; microscopically. ’ 2 ' Duodenal parts. Slight catarrh., Considerable congestion and edema in ; submucous tissues. . Small-intest. Intense hemorrhagic-loucogytio inflammation with . fungous swelling of musous membrane, due to Anthrax-infection, ? . , Large-Inteat. No remarkable changes, macroscopically. poo meeenererecewnee oma eo ranma om ae on am on om om om seen carta eee a eee - Kidney. Slight Glomerulo-nephrosis with slight polar changes. ‘Nephrosis I, with considerable interstitial edema end intense vacuolar degeneration of tubular epitheliums at subcapsular pertiona. | Om ae me were ee nee eee Rem Be Renee ee Renee Ree REN NEE ENE DARE RENEE ' Spleen. Angio-Follioulitis haemorrhagico-exsudativa. Spleno-Fasciculitis haemorrhagico-exsudativa. , Lymphenode. 7 Mesenterial: Lymphadenitis haemorrhagioa. at j . , , _ Peribronchial: Lymphadenitis haemorrhagica gravis. ' Tonsil, Tonsillitis catarrhalis acuta. Intense congestion and edema in follicular and peri+ follicular tissues, accom panied with multiple : ; hemorrhages and some paneony Vesr etteration. | Bronohua. Considerable congestion and some hassoriaaen in aub- mucous tissues., 4 4 \ . — ke ‘eal > .. Bronchtolus,. 7 y Lung. Xam ema mene , Pancreas, . ar) _ Supra-renel, ‘Thyrecid. Pituitary B. Testiche. — eae meen me arr td “1 Gerebellum. Bronchiolitis necroticans and Peribronchiolitis, Acino-lobular catarrhalic=-necrotisc pneumonia with ? - Pleuritis haemorrhagicas Considerable degeneration of parenchymatous cells and. some atrophia. Considerable congestion and slight perivascular round cell accumulation. ; Intense. vacuolar degeneration of island-cells. Vacuolar degeneration of cortical cells, Considerable congestion, some diffuse hemorrhages in 2, reticularis and intense edematous swelling of cortical tissues. — , Vacuolar degeneration of wedullary cells. ; In acute disfiguring. (follicular collapse). Atrophia testis 1. oe OO Oe om Om Oe OF Om OD OD OF WF OD aD om we OS Ot On On Se nn Om Be Oe Ome me Oe ne OD we Om Ome ome oe fae fe Oe oe Oe ee Oe wae! Slight congestion of meninges. Considerable congestion, slight hemorrhages and some edema in brain, . Slight congestion and slight edema. ? Skin, ? No remarkable changes. : -Batrance-ports, - @ . Days of course, ’ ’ Bronchus. ’ '.. Bronchtlous. i ? ~ Tange 27 years old. 3 4 Per-nagsal infection. ‘ Considerable degeneration. Slight congestion (some leucocytes in capillaries) and slight edema, Some histiocytes. . No remarkable changes. ’ Tonsillitis catarrhalis acuta. Intense bionecrotic swelling of mucous epitheliuns, _ (bacterial inbrusion in epitheliums). ‘ Intense congestion and edema in folliculab tissues. Remarkable swelling of germinative centers with some bacterial accumulations. Intense congestion and edema (some leucocytes in Submucous tissues. : Intense congestion in submucous tissues, ? Peribronchitis with congestion and some hemorrhages, -~ : eS ‘Bronchiolitis catarrhalis gravis and peribronchiolitis,: Diffuse Alveolitis and some lacinous hemorrhagio places. ee ae Oar as Ok Tn Om OD eb OE SO OD SE GS AD GE ED Be Om OD 08 9 MD OF Os BD OD Get OD OS OD ot OF OD Om OH om Bt OE OF OD OF a me PO we ~ wey + ane ¢ Ms ? . Liver, Oan not be investigated, microscopically. Stomach, _ Slight catarrn, Ca. - Small-Intest. Considerable catarrh, Large-Intest. Slight catarrh, considerable congestion and slight perivascular leucocytes~accumulation, TERROR eR OLR ee eee meee ne meee enema nee ee '; Kidney, Slight Glomerulo-nephrosis with slight polar changes. Nephrosis I (or III at some places), with intense a _ interstitial edema. Spleen , -, e ’ "Lymphemode,. ‘ Mesenterial: Slight catarrh. - Peribronchial: Lymphadenitis haemorrhagica gravis, a a mm OO OO OO ee ? > Pancreas. | Considerable degeneration of parenchymatous cells and island-cells. Some edema. Supra~-renal,. - Thyreoid, - Pituitary Be - “Testicle. Atrophia—tostis. : Brain. = . Skin. No remarkable changes. : : 7 “ae 7 "ats, 37 years old. ‘ a Entranoe-port. Pernasal infection. ‘ a a ‘Days of course. 3 days. iar ar tas RS ee eee ee PT n eRe cea! eg yh, ey ee oe Pom ag —— Sa Ss Heart, . Considerable degeneration. Some atrophia. " Aorta. — No remarkable changes. Tonsillitis catarrhalis acuta. ' _ Gonsiderable congestion and edema in follicular and pe rifollioular tissues. ? . ‘Gonsiderable swelling of germinative centres. Considerable congestion in’ sybmucous tissues. 7 a ‘. Bronohus. . Peribronohitis with some hemorrhagic places. Bronohiolus, Bronchiolitis catarrhalis. (Stung. “Ho remarkable changes, Liver. ad : Hepatitis serosa II. . Stomach. a . Slight catarrh and considerable congestion in submucous | | - ‘tiesues. . ; . | | 7 mae ? - Smelieintest, Considerable catarrh. Large-Intest. _ No remarkable change, macroscopically, Cate ates & 1 1 a Haney, | SLtgnt GQtomerulo-nsphiesis with: eer. 2 : : . | Nephrosia I (or III at some places) and ™: = oles Nephritis interstitialis at some places, with sme : round cell accumulation, considerable edema a and considerable hyperplasia of connective tissues. 1 Oem em mae in Sern ewenne alateatetatetelataatetetatetoten alta delatetatl # a . é ‘) Spleen. Aneto~Potitoutitis, — -: “ Lymphnode, ’ Spiene+Faceteuttiots. - Mesenterial, Missed, : ; ‘ ', , Perlbronohial 3 Lymphadenitis haemorrhagica. he OO FE OD OO 8 OS OF OR Om Oe OF Was OD On Om wm Om Sn 0 OD OD OS Om OO a OD SO On A OO OE AO He Os ew on - o a ae “> Thyreotd. In acute disfiguring(follicular collapse). 29 years old. Entrance port. Pernasal infection. “. Deys of course. ca.2days. 0 Oe On Ot Om tam Oe mt ae ca th ah ON ca fat me OY LAD OO OO Oem AD Om np Gd Ey if ts oy Oe Oe oe a GN OY IE ON OOO OED he OO OF ON a On DO OE OD Oy Om "emma = Heart. a Considerable degeneration and interstitial edema. Sepieliidntacdccieataecdosasbouatae weene weaeenew uc ween nnn en ee eRe “Laver. Hepatdtis serosa 1l.with remarkable exudation and i. congestion. ‘Stomach. . No rewarkable changes. . : Xe Large: ntest.No remarkable changes. 1 teh sm oe tt oh ae tH OP Sat ts I Oe DBD tem Ow OP om Ont FS Wy OD we me ee oe ae wt ae mw en Ce re “Testicle. | Atrophia testis 11. thee Sm 00 0 oe = oe as oo at ca 0 ah a es es ot Sn tno wes tat oe ot ee 0 om ee we Oo a an we as om om oe en a0 hh om oe oe ett ; f Other organs.Can not be investigated,microscopically. yee . n es 2 Spleen. é ’ 31, years old. e ¢ -+-Entrance-port. Pernasal infection. * Days: of course. 4 days. | Heart.’ Considerable Seathetatacs and some abeopbia.~ Some edema and some uewendignel: reations. 7 : i hee Aorta. - No remarkable changes. - Laie ee ca Heecnnesseseseesns Ker eceocacnenaena= Tonsil, - ~: Pharyax. - . ‘ - ; i 7 bins Some bacterial masses in bronohilolus. oe \- Lung. Stasis and edema pulmonu, with numerous bacterial co masses in alveoli, Laver, Hepatitis serosa II-III. Stomach. No remarkable changes, winsoadovisaity. : a ; Small-Intest. Considerable congestion in mucous end submuaous tissues, microscopically. > . Large-intest. _ Slight congestion. 2" Qe pt 60 Ak Om Om dae BP OM Sm OF OS OF OD OH Oe EE ED On OF SD OP Be a Se ow Om OD aD EE OD om ED OD OF ON ED ED oe OD ow et me SOR MMM min ome 2 ts a 4 : * Lymph-no de e 4 ' Mesenterial. Follicular congestion ‘Peribronohial ; Lymphadenitis haemorrhagtoa with considerable folli- | ¢ cular congestion, (oo eh Gee OH OF an AD Gab OD Ge GD ED OO re BD OD GO CD me FOS OR Ce Gas OS OO OND ms GD OD OF tm Hib fa ten ot Os (oe om nn 00 an 00 as a oe SO mm me ined : ’ Supra-renal, Vacuolar degeneration of cortical cells. : Some edema and intense diffuse hemorrhages in'Z. : reticularis. : Brain. : - ’ : 7 : ; - Skin, : No remarkable changes. re —___ a : Years and sex, * BT -%) - : Entrance -port. _ Pernasal 1gfeection. Deys of courses. 3 days, ee te ne ee ea eee em ee me ee me eee Heart, Intense degeneration. Considerable edema and ra Atrophia, Aorta. No remarkable changes. | Oman nes ew mme newer w an we mee cer ce we neree nm me eee cower w enna nesewee Tonail- Tonsillitis acuta with bionecrotic swelling of mucous epitheliums, toe ae ‘Antense congestion end edema in follicular and peri-follioular tissues, . : intense hemorrhages and some bacterial accumi- lation in perifolliculer tissues, . bionecrotio swellingof germinative centred and | intense congestion in submucous tissues. Bronchus. Considerable congestion adn edema in submucous : : : tissues. Sows a Bronchiolus. Bronchiolitis catarrhalis. ; Fe a ae ‘Lung. Slight congestion and at some places atelectasis, Liver, Hepatitis serosa II-III with ' - multiplemiliary necrosis(some leucocytes, a few histiocytes and a few lymphocytes , and decayed ' masses), . : ‘Stomach,. _ Slight edema and consid able congestion in imacous, a _ tissues. a a ie eee Small-Inteat, Catarrh and edema in mcous tissues. Ne a! | Some inflammatory changes in submucous tissues with edema, slight hemorrhages and some perivasouler oe oe 2 ty wandering cell accumulations, . Lapge-Intest, No remarkable chamges, baat ent ed atta ieee a letietekatek ated enh akad tot tt Pee ee owen een eee = Kidney, Slight Glomerlulo-nephrosis with slight poler | changes. a0 Stay are Nephrosis I (or III at some places), with con- siderable interstitial edema, Spleen. Angto-fotttoutitts . —. Faseioulitis, Lymph-node — Mesentrial: ymphadenitis acuta with slight exudative _Peactions(congestion and some leucocytes), Peribronohial L. haemorrhagica, - Peer nO rene ewe eee wrecere Ove ne Cem emer e een mente cee es wee Pancreas In autolysis. Vacuolar degeneration of parenchy- | matous celle, shat Supre-renal, Partial hemorrhages in cortical tissues and intense edema and diffuse hemorrhages in Z, reticularis. — Vaouolar or intense degeneration of cortical tissues (ruining processes of cortical cells),with some round cell accumulation in Z.fasciculata and ET. bees Z. reticularis, 7 Remarkable atrophie of cortical cells, Yi Edema in medullary tissues, oe Thyreoid, In acute disfiguring (folliouler collapse), rt with some bacterial masses in capillaries. Pituitary B, - Teaticles Atrophia testist , Brain, Considerable congestion ans slight perivascular _ hemorrhages. Oo a OF Oe ew Oa a a ee oe a OO we Oe am i OO OOO OP A UO om O00 Oe ae OE OD wD tee Ons Skin. No remarkable changes, HEART eee, ; v (A) Mtcrocopical Investigation, i. | Considerable parenchymatous degeneration and edema, 26. | | No remarkable changes, 5S, Basophilic degeneration of some muscular cells, Slight mesen~ , chyna reactions, Severe parenchymatous degeneration and atrophia. Edema in inter- stitiun, 225. as Considerable parenchymatous degeneration, ST8. cae Considerable parenchymatous degeneration and atrophia, Pertial hemorrhages in interstitium and desolative decay of the . neighbouring muscular fibres, Considerable venous congestion, 520. Slight. parenchymatous degeneration and considerable atrophia, Ingerstitial edema. 325, _. Severe parenchymatous degeneration and considerable atrophia, Remerkable perivascular edema and some myocytes-accumlation, 97 ee: fidey 328, eee ee Severe parenchymatous degeneration. Severe venous congestion and slight hemorrhages in interstitium. Many leucocytes in blood= vessels. 583, : Severe parenchymatous degeneration and considerable edema. 3a8, ; . Severe mrenchymeatous degeneration, 389, . _ a : Condidersble parenchymatous degeneration, 390. - Severe perenchymatous degeneration and congestion. 303, Severe: parenchymatous degeneration and considerable atrophia, Severe venoys congestion and considerable edema, Slight hemorr= hages in interstitium. . Severe atropia and considerable parenchymatous degeneration, Severe edema and accumulation of leucocytes in bdlocd=vessels, 397. 7 ae ee ptt - Slight parenchymatous degeneration, Considerable edema and hemorrhages in interstitium and epicardial tissues, —_— 399, Conaiderable parenchymatous degeneration, edema and hemorrhage in interstitium, Appearance of some myocytes, 400. . Considvable parenchymatous degenefiation wth slight mesenchymal reactions, | 401. 7 ery Consideradle parenchymatous degeneration and basophilic: ‘degenera= tion of some muscular cells, Some mesenchymal reections end oltgst : infiltration of seg eeeean: at some places of interstitium, 403. , r Some parenchymatous degeneration and edema. Endoartef#Yitis of ‘some erteries (with small round-celleinfiltration in. intima). 404. : Some parenchymatous degeneration and edema, Remarkable perivascu~ lere edema around some blood-vessels, with histiocytes -accumulat = . don at some places. 4065. Severe parenchymatous degeneration, atrophia and interstitial edema. | 407, . . 7 Severe p¥renchymatous -Gegeneration, atrophia end interstitial ecena. wt ‘409. - Oonsiderable parenchymatous degeneration, atrophia and intere- stitial edema, 49 410, a. - Considerable parenchymutous degensration, satrophia ofa, interatitial 1 edema, Some myocytes around blood-vessels, 4II. ; Considerable parer.chymatous degveneration and atrophia, Some mesenchymal reactions. Accumulation of many myocytes, 412. ; ’. Some parenchymatous degeneration, atrophia and edema, Leucocytes in Dloodevessels, Accumulztion of histiocytes around blood -vessels, 413, ; ; oo Considerable parenchymatous degeneration and atrophia, , 414, oe . . Considerable parenchymatous degeneration, atrophia and inter- atitial edema. 416, a Considerable parenchymatous degeneration, atrophia ané inter- stitial edema, Slight mesenchymal reactions, —4t7, os . Severe parenchymatous degeneration, considerable atrophia and interstitial edema, loo Investigation on 3I microe-slices. a) Eptcardium with severe edema, Generally no remarkable changes else, In I specimen, some mesenchymal reactions with leucocytes~ infiltration, » bd) Myocardium: In many cases, muscular fibres are atrophic with plenty of lipofuscin-deposits, Generally with severe cloudy swel- | ling ‘and occasionally with slight hyaline degeneration, Slight “vacuolar degeneration in 6 cases and basophilic degeneration of some misoutar cells in 35 cases, Severe edematous swelling in interstitial tissues and frequently slight exposed perivascular hemorrhages (4 cases of them in severe degree). _ In one-third of all cases, intense congestion, and occasionally» leucocytes accumulate in blood-vessels with more or less intense perivascular edema, _ oe ; ' Inorease of adventitial cells in some cases. Rarely round-cell ; _accumlate in interstitium, 4 specimens have many myocytes, which in 1 specimen accumulate as glanulom, co) Epicardium with edema and round-cell-infiltrations. spi ls Fae ag OR 24 (—{-1=] Disieone pettance 95 STATS eT = Fatale Gao dy Swelling [+] : ool & Te fa | epee ma EE EE ee te SH ‘e 0 a no peboede [be ee | fr] fod Poel | PEERED eee PER ab hhh heb brit) | Pst Necrosis” J-J- | Perknosis {-t- Tet i ee = {= | a + ooo a 9 | Blood yessels: =| =] = | Ei =] ka 273 ets] fErvinrocytes [+ [+ | Hee wes totes [* | |Lymphocyres {= [3 [=] me EE |e] = (4) ry CCT Sen a EY shred tes fil-| i UCOCYTES A] L Lymphocytes [1 [| ar ea | =| [= | =| | =| = + | pes © ~~ Eaebnslaoills ee Fragrentation t= Gabe bee eee ae ” oe ee = Re be ete arta o. —in-f=f-|- [ei I] Fitch cd faced Erne aed a col bone Racal Se SeoSShnss feito ateateete EI Sod Rene Reid ced aoe = [4p le [oo fea + [Ta Le | at ee SE eS a eo ed Contents Ppimrocyres ts [+1 Rte the a ee : ‘ Pihonoertes Ts ES ane te eg ea ‘ ai raon ef Lencaeyies (=f fal P= f= [lel =[—a fll NA mks) Lymphocytes [= | lee lenten{= [= [~ feat — [+o [= [oot | albllteration THistiocvtes [== fl = ef [ots fee Te TT [=] ‘he{Proliferation of Maori Bee fee ee pep ce ye dc] —[—] [= {= [=f ja || ~ 1 {—! a See + TH iH + ta I: A ~LErythro cytes} : E A ag f S¢ § Ag : 33 .. 3 24 : Bee Hy be . oF ae # iB : Hemorrhages in intermuscular tlasues, ; Myocytes -granulom, , Bronchiolitis _ . Stasis pylmonum Pe _ Bleeding--------> “+~-Edena pulmonum Pneumonia ----- - ----+-Caseous Necrosis : Bacrerial __ Atelectasis ; : _ Folonies- ~~~. Pleural Hypemia’ ; ‘ ( ‘oe oft * LUN a . ; (A) Microscop. Investigation. ce | Almost normal 18. re Almost normal. Edema et. stasis pulmonum levis. Bronchiolitis catarrhalis levis, Pleural hyperaemia 26. e 2d& si Edema et stasis pulmonum gravis. Bacterial coloni-. es in alveoli, 225. Edema et stasis pulmonum, Bronchiolis. Bronchiolitis catarrhalis, Slight congestion of alveolar Jeapiaveriea? and slight. edema, Bacterial eolonieds 4in alveoli, 325. ; ' Acinous -nodose lung-tuberculosis, .(conglomerat- -* tubercles -formation) No rewarkable changes else. 528. . - : ; P a Acino-lobular lung-tuberculosis in productive, somewhat exudative form, The focal parts of : tubercles are ‘ebseous with cavern and perifocal parts rather proliferative. with pees ere cells 348. (Yr. sup) and giant cells, : ss These are surrounded with moderate lymphocytic* =. hemorrhagic reactive zones, No rewarkable changes else, 388, (right superlor), *Bronchtelitis catarrhalis, slight emphysema and atelectasis, 388. (right peasant . Endohronchiolitis catarrhalis and Peribronehioli- tis acute with inflammatory swelling of peribron-~ : ‘ chial lymphodulus, which fall into totally hemorrh | gko--end>parttally necrotic state and bacterial - nccumateetone in peribronchial TyapacvesEets or ~nodulus. ' Generally slight inflammatory swelling and congesti on in peribronchial tissues, Slight congestion and slight edema of alveoli. 289. (right superior), Bronchiolitis catarrhalis. and slight Alveolitis (congestion and slight emigrations of lymphocytes. _ and leucocytes in alveolar-walls), 389, (right inferior). Moderate Alveolitis (congestion, noderate emigra~ ‘tions of leucocytes in elveolar-walls) and edema . pulmonum, 389. CL. sup) 319.(1. mf.) SRT Sane ee h peretanes da Slight leucocytes -accunulation in pensbroneh tes Lymph -nodulus and 4ronchiolitis catarrhalis, Slight reactive Pleuritis (congestion and edematous swelling of pleural tissues), 389 (left, superior). aa slight Lymphocytes -emigration in alveolar walla, 389 (left inferior), | Endobronchiolitia catarrhalis and Peribronchioli- tis. Slight. lymphadenitis acuta of peribronchtoler lymph -nedulus (inflammatory swelling and leucccytic acoumlation in lymphodmlus) and slight * oe Leucocytic einflitration of peribronchiolar tissues, Slight. plumonal edema and ‘slight, leucocytic’ emigra+ : tion in some acinus of catchment-area to attacked bronchiolitis, Edematous swelling and slight diffuse bleeding « of. interlobular connective gees. 390 (left suberior), ‘ Diffuse Alveolitis: and localised miliary hemorrhagic pnowronia, Edematous swelling, | considerable congestion, | ond leucocytes -emigration at slveolar walls and : ae... .. 393. (vr. sup.) furthermore at some places multiple miliary hemorrhagic pneumonia : most parts of them are strongly hemorrhagic (hleeding and separation of fibrinous masses) and fall into partiall necrosis with many leucocytes ~fragments, These inflammatory changes spread with severe exue~ dative reactions (cell-inflltration and henorrhe- ges) to the neighbouring tissuea ( = diffuse, Alveolitis). Eronchiolitis catarrhalis in hign degree and considera le congestion, slignt cell-infiltration and ecenatous swelling of peribronchial connective tissues (Peribronchiolitis), 393(right superior). _ Bronchiolitis catarrhalis and slight diffuse Alveolitis with partial slight aniphyaeme,: 93(right inferior), __ a Endobronchiolitis catarrhalis in high degree and diffuse Alveolitis +: edematous swelling, congestion and leucocytesemigration at alveolar walls with edema and slight erythrocytes -leakage in alveoli. Becterial colonies in some alveoli, 393. (CL. sup.) 4 398..( Lo.) edema pse~cells in alveoli, Edenstous swelling, slight round~cell-infiltration and songestion of peribronchial connective tissues - (Peribronchiolitis), : 593 (left superior). Brenchiolitis and Congestion pulmonum: slight congestion and slight cell-infiltration at alveolar walls (slight Alveolitis), In pleural tissues, considerable congestion and 7Aenutous swelling with many procuctive miliary tubercles, (Pleuritis tuberculosa productive and | teactive inflammatory changes, due to Congestion: pulmonum), S93(left inferior), ok -Bronchiolitis catarrhalis and diffuse Mveotitia: congestion and leucocytes-emigration at alvoolar walls, , . Slight round-cell-infiltration of peribronchiolar tissues (slight Peribronchiolitis) and slight — hemorrhages and edematous swelling of pleural tissas, (reactive inflammatory changes of pleural, tissues).596 (right inferior), 7 _Bronchiolitis catarrhalis gravis (bacterial colonies as contents) and diffuse Alveolitis + leucocytes-infiltration at alveolar. walla, elight 36. (hi sup. & inf.) ’ Bronchiolitis catarrhalis and diffuse These diffuse Alveolitis develop at some subpleural tissues to acinous hemorrhagic pneumonia (severé ke congestion, hemorrhage, edema, desquamation of alveolar epitheliums and bacterial accurmmlation in some alveoli), Bacterial colonies accumulated at some places, esp..- in alveoli, in pleural tissues and in bronchioll, 396(lert superior and inferior), Bronchiolitis catarvhalis levis, Slight edema, No remarkable changes else, Z97(right superior), Alveolitie levis: slight cell-infiltration at alveolar walls, ; Slight pulmonal congestion and slight edema, 399 (left superior), Partial slight pulmonal congestion, No remarkable changes else, ; 399 (left inferior), Siight congestion, Heart dese~ ase cells in >ronchiolus, , No particular changes else, ae. 400, 2 400. Bronchiolitis catarrhalis gravis and diffuse Alveolitis : edematous swelling and leucocytes~ eemigration at alveolar walls and at some places in severe degree, These inflammatory changes develop at some places (peribronchial ae subpleur- al tissues) to acino~lobular hemorrhagic pneumonia (severe Alveolitis, leakage of leucocytes and severe Dleeding 1n some alveolar spaces, attached to catarrhalic bronchioli), Subpleural severe congestion and sero-fibrinous Pleuritis at adjacent parts, 401. ,Slight stasis and slight cell-infiltration at alveolar walls, : No remarkable changes else. 403, Bronchiolitis catarrhalis and acino-lobular pneumonia with diffuse Alveolitias remarkable leucocytes-emigration at alveolar walls and leakage of leucocytes in alveolar spaces to form multifocal acinolobular pneumonic places, In peribronchiolar tissues, edematous swelling and slight cell infiltrations. (Peribronchiolitis ~ levis), 405. (r. sup.) ‘ YY 405. ( L. sup.) Wk 405. (right superior), Slight stasis and Alveolitis diffusa in slight degree, No remarkable changes else, 405. (right aan . Multiple acino-lobular pnewnonia with diffuse Alveolitis and following intense reactive changes sremarkable congestion and remarkable leucocytes- -emigration at alveolar wal’s and inflammatory edema, leakage of leucocytes and heriorrhages in alveoli, which develop at some places to miltifo- _ cal acino-lobular hemorrhagic leucocytic pneumonia, 405. (left superior), changes else. 405.(left inferior). Multifocal acinous hemorrhegic exudative pneumonia Diffuse Alveolitis * considerable congestion and leucocytes~emigration at alveolar walla. At some places leakage of leucocytes in alveolar spaces to form multifocal acino-lobular pneumonic places, , accompanied with severe hemorrhages and leucucytas- -Linfiltrations, x » 406, Fulmonal congestion and slight edema. No remarka~ ' ble changes else, bt 5 407, Bronchiolitis catarrhalis levis, Considerable congestion and edematous swelling , of-alveolar walls to form at some places atelectasis of alveolar spaces. No remarkable changes else, 409, _ | Bronchiolitis catarrhalis levis and diffuse al- ight Alveolitis: considerable congestion, edematous svelling of alveolar walls and leucocytes ~emigra— tion at diveslad walls and at some places remarka- | ble atelectasis of alveolar spaces, due to edonatous swelling of alveolar walls, Edematous ewelling and bacterial dissemination © in ad jacent pleural tisses, 410. he Bronchioligis catarrhalis and diffuse Alveolitis agar : slight edematous swelling, slight congestion and slight leucocytes- infiltraion at alveolar. walls with desquemation of alveolar epitheliuma and slight ddema in alveoli, 411,00 | Broncho-Bronchiolitis necroticans, acino-lobular catarrhalic-leucocytic pacunonia and Pleuritis oo"! haemorrhagico-fibrino3a, : ae ae: A large yuantity of decayed masses and pacterial | colonise in droncniolus, ‘WeNeorotic ruins of ‘oeonchioler walls and edematous and inflammatory svelling of peribdronchicler tissues in high degree, These bronchogenous inflammation spread to multifocal acinous or scino-lobplar pineuionie changes in attachment-areas +. leucocytic-hemorrna-: gic infiltration and at some places necrotic ruins of alveolar walls. These inflammatory processes spreac to the neigh~ bouring tissues with more or less considerable . exudative reactions? severe Alveolitis, namely ; considerable congestion and leucocytes -onigrations at alveoler walls and at some places with inflemma- tory édeua, wlth licomerrhouges and leucocyttc need in elveolsr spaces, Remarkable congestion, diffuse nemorrhages and separation of fitrinous wasses in adjecent pleural . tissues (Pleuritic haenorrhagico-fibrinosa) and — multifocal acinous henorshugic-exucative pueuneeS,. of subpleural lung-tissues + severe congestion, bleeding, leucocytes -emigration, Seeayes masses: of alvooler epitheliums and bacterial deposits in. FG 412 (b). preumonic places, 412 (a). Broncho-Bronchiolits gravis and Peribroncho-Bron=" ehiolitis gravis vith rewaykable ciffuse Alveoli- Catarrh of bronchus in severe degree = a large quantity of es starr helic masses, hemorrhages, desquemation of alveolar or bronchial | epitheliums | end dacterial colontes as contents, Severe exucative whenges of bronchial walls and severe edematous swelling, severe congestion ane diffuse hesiorrhages in peribronchial tissues, These inflamuatory procesces Spread to the - ‘adjecent Sroneuivlar or peribronchiolar tissues, and moreover to lung-tissues in catchnentareas, Namely in. lung-tissues of attachuent ~areas, multi focal acinous herorrhagic-leucocytic pneumonia with diffuse more or less remarkable Alveolitis in the neighvouring General lung-ticsues (considera dle. congestion, leucocytes -emigration of alveolar |, walls and at some places leakage of leucocytes. and hemorrhages in alveolar spaces), . 412.(). Bronchioligt Slight diffuse 413. (re Mnf.) 417 (right superior), Alveolitis and aultiple acino-lobular hemorrhagic pneunonia in peribronchiolar pulmonal tissues, - : considerable congestion, leucocytes ~omigration |. at alveolar walls with edema or slight hemorrhages: in alveoli, These hemorrhagic processes develop. at some places, esp. at peribronchiolar tissues, to “acinolobular hemorrhagic pnaumonic changes, . .. 413, (right inferior.) S: -Bronchiolitis catarrhalis levis and very slight” -eelirinfiltration at alveolar walls. No remarkable: changes else, — ; eae 413 (left inferior). rhe ae eae - Bronchiolitis catarrhalis levis. No remarkable changes else, zo 416, aie apes Congestion et edema pulmonum in high degree.’ ; Remarkable edematous swelling and severe congestion of alveolar walls with inflammatory edema and: slignt hemorrhages in’ aivegtts Bacterial masses in some alveolt, ‘and bronchtolus, Bronchiolitis estarrhelis, Edematous awelling : : . and atest leucocytes -emigration ate alveolar . walls, to form ae some Drees atelectasis. of | - alveolar spaces — i ay (r. inf.) . iia 17, (right inferior), Bronchiolitis catarrhalis, Edematous swelling : and eutEnt: cell-infiltrations at alveolar walle, to form severe atelectasis of alveolar spaces, 417(left inferior), Bronchiolitis catarrhalis gravis and diffuse ; Alveoltis 3 ‘edematous swelling, considerable 2 : congestion and cell-infiltration at alveolar walls’ with pavers ‘atelectasis of alveolar apaces, Ide 17. 18, 26, 225. 318, (B). BUMEARY, (I) The bird's eye-view of all investigated cases. ' Almost normal, Edema et stais pulwonum levis and Bronchitis catarrhalis levis. Elema et stasis pulmonum in high degree, with some bacterial dissemination in alveoli. Edema et stasis pulmonunm, Bronchitis catarrhalis. Bronchitis catarrhalis. : ; Edema et stasis pulmonum levis, with some bacterial dissemination in alveoli, Acino-lobular tuberculosis, No significant changes, due to Anthrax-infection, bss Aobullex tuberculosis in productive, somewhat’ exudative form. No significant changes, due to Anthrax-infection, (right, superior). Bronchitis catarrhalis, Slight emphysema and considerable atelectasis at some places, due to edeihatous swelling of alveolar walls, (right, median). Bronchitis and Peribronchitis acuta with intense Aeworebaalaeheowen tic changes of peribronchial lymph-nodulus, Edema ae stasis pulmonum levis, (vtght twuperlon), Bronchitis catarrhalis and slight Alveolitis diffusa, *“ $89, 389, 589, 390, ‘ (right,inferior), Bronchitis and Peribronchitis acuta, with some leucocytes -dissemina- tion, ; Alveolitis diffusa in medium degree and Edema pulmonum inflammtorium in slight degree, ; Some pleural congestion, {left, superior). Alveolitis diffusa in alight degree, with some lymphocytes -emigration in alveolar walls, ; (left, inferior), Bronchitis catarrhalis and Perlbronchitis acuta with some congestion | and some inflammtory changes of peribronchial lymph -nodulus, Slight’ edema and some loucocytes-dissemination in some acinous places, : Slight hemorrhages in inter-lotular tissues, (left, superior), ‘Diffuse Alveolitis with some localised hemorrhagic pneumonic places, Edema pulmonun in medium degree in the neighbouring pulmonal . tissues, | a Bronchitis and Peribronchitis acuta with some inflamtory changés, peas 593, (right, supertor), : : Bronchitis and slight diffuse Alveolitis, — : ' 293. (right, incerior), | Bronchitis catarrhalis and Peribronchitis with some congestion and ‘ edema, Diffuse Alveolitis with Sligat hemorrhagic changes and some bacterial ‘dissemination in some acinous areas,,. (left, superior), Bronchitis and some pulmonal congestion, . a Some pleural congestion and Pleuritis tuberculoga productiva, (left, inferior), : Bronchitis and Peribronchitis acuta with slight round-cell-infiltra- tion, ; et _ Some congestion and some hemorrhages. in pleural tissues, 396, (right, inferior), a Bronchitis catarrhalis gravis, ; Diffuse Alveolitis’ with some hemorrhagic pneumonic places in subpleural tissues, ; 396, 7 7 ace vel a ae) a { : a Ee (left, Onaceteost: s Bronchitis catarrhalis and slight etcuza, _ No vemarkeble changes else, 396, 397, (left, inferior), Bronchitis catarrhalis and SuEnP edema, (right, superior), Bronchitis catarrhalis and slight diffuse ALveolitis, 399, 400, (left, inferior), - Slight pulmonal congestion, Bronchitis catarrhalis gravis and Peribronchitis acuta with some hemorrhages. - Diffuse Alveolitis and some acino-lobular, hemorrhagic pneumonia, 401, 403. 408. 405, ‘Pleuritis sero-fibrinosa with intense pleural congestion, Slight Alveolitis and slight pulmonal congestion, Bronchitis catarrhalis and Peribronchitis acuta. ~ 7 Diffuse. Alveolitis and multiple acino-lobular pneumonia, (right, superior ),. : de beg Diffuse Alveolitis and musbrete etnotn un Leusooytic-hesorrhagie pneumonia, (left, Sisaceee ti: Some bacterial masses in blood-vessels, No remarkable changes else, 405. (left, inferior), Diffuse Alveolitis and » multiple ecinous hemorrhagic-exudative pneumonia, 406, Pulmonal congestion and slight edema, Bronchitis catarrhalis levis. : Slight edematous swelling of alveolar walls. . Rather atelectatic alveolar spaces , due to edematous swelling and © congestion of alveolar walls, No remarkable changes else, 409, Bronchitis catarrhalis levis, Slight diffuse Alveotlitis. ; i ie eee ee Remarkable atelectasis, due to edematous swelling of aivecler walls. Edematous swelling and some bacterial aie s ous etek in pleure. : tissues. : 410, 411, 412, 412, 413, 415, ( vo. 416, pepe a Bronchitis catarrhalis and diffuse Alveolitis, Broncho-Bronchiolitis necroticans, : Acino-lobular,catarrhalic-leucocytic pneumonia, Pleuritis haemorrhagico-fibrinosa, with multiple acinous hemorrhagic-exudative pneumonia in subpleural tissues, ; Broncho-Bronchiolitis in intense degree and “eribronchitis in intense degree, ae intense diffuse Alveolitis with same inflammtory edema, Bronchitis catarrhalis and Peribronchitis with some congestion and some hemorrhages. . Slight diffuse Alveolitis and ; : multiple acino-lobular, hemorrhagic pneumonia in peribdronchiolar pulmonal ticsues, a Bronchitis catarrhalis levis and very slight Alveolitis, No remarkable changes else. left, inferior). 5: Sa a Bronchitis catarrhalis levis and no remarkable changes olse, Edema pulmonum inflanmatorium and Stasis pulmonum in high degree,: with some hemorrhages ahd some bacterial dissemination in some : ‘alveolit and bronchioli, 417, -. 417, (right, superior). Bronchitis catarrhalis, Spy ‘ Remarkable atelectasis, due to intense edematous swelling and slight coll-infiltration at alveolar walls, (1éft, inferior), 7 Bronchitis catarrhalis gravis. Diffuse Alveolitis, | Remarkable atelectasis, due to edematous” swelling, congestion and some cell-infiltration.at alveolar walla, seen (2). . I divide all gases in to 2 groups : a)peroral infection and b}pernasal infection, (a). On peroral. infection, |: Peroral infection caused s»r-etimes no particular changes, iv | 325. 528, " 1. 225. * gome: bacterial dissemination in pulmonal tissues. (secondary motentatic. } ye | € ‘pneunignt changes). : fas na Sonetimes ‘caused alight or intense diffuse Mveolltts, ,accompanied with vt rod (b i On pernasal infection, ‘All patients, affected with pernasal infection, died aifinitely after _ several (2 - 5 ) days- course, : I have investigated 2 0 cases of them, °) 10 cases of them died’ in slight or intense diffuse Alveolitis, which were caused mainly by Peribroncaiiis and Bronchitis, following sings of |. ' pernesal infection, I case of them, in intense inflammatory edema, acconipanied with some hemorrhagic and bacterial dissemination in some alveoli, And I ‘case of them, in intense inflammtory congestion, Intense congestion or intense edema of alveolar walls caused frequently remarkable atelectatic changes, Atelectasis, due to pulmonal congestion or edema, is one of the main pathelogical changes of this disease, “p. Bee In 10 cases of them, developed these Alveolitis into the more intense .pulmonal changes : (intense diffuse Alveolitis, Bronchitis and 'Perlbronohitis), accompanied with some hemorrhagic and leucocytic changes in:;multifocal acinous or acino-lobular areas, ART 2 cases with intense hemorrhagic-leucocytic “pneumonia all over the pulmonal tissues, caused furthermore some intense pleural reaction with: Pleuritia sero-hasnorrhagico-fibrinosa, (Si eayriresvtes ——— T= fe) — aeeore fatale = — r Heart Be 307 Firir EEEEE EEE dpe. Bac = tele lait] Pe pb pe dete] i Hemormage [= (= === = l= ea = LeucocvresFe [— [1 [= [—[=[— [laf 7 ctl dele SIScr.. _ io RPronferation sh sfiswome test = [= Flatts eta = I t covering Hasses = [=| —| Pf Pol WEB ad EG ec Red Cee) Bred 0 ot nad 0 el J See iol sree aaa | LUNG Dacrerium iDesquamated.Epitheria Ca |Gofonies of Sa DedS 1E(00MIV | __ Emphysema --—telectasis T=] Edema Leucocytes ympnocyres ap ap [Desauamarea pirhe seloaniy |” S491 G07 _| wewouaia ad] SW IUD| se aseAis3 L_____yosaty | uowrouosg SI9S5e/ POOId. nd fan Eh: Lt LL | nono Sqn a0000 HeOuEO An SOO eit }+] donno ans 0000 Se TAHA San Rn SSE on SOON O noose SOO conn Snnee = DR DAD STAD OSD Ono coo Onno STS O TTD ORS ORO OOOO OOOO R EA ORNs noon Ee MS DE ES SS SS SNS OE CO SO ES NES EO MEN Ne SS SE DES EM DDE ECT SHDN VESES ENURESIS GE Pee Fa ue os outlays eo En etaTah fete lst lol iste RE TATE Tete Ba++ aog0300nninseo Ae SOnnOnaanONE: Ag ONOOSoOIN AE E 5 emorrnase leieseatt ‘all — i TEE BL age [Leucocytés | it emorr -—, Edema Congestion Infiltration Pro LUNG Se s foe le a a eal) 8 | = | [~~ |= [~[+|—]- [+ [> [+] |— |= | ey] =| va id p-|— |— Jf TI [4 [— [=|] sis ble I= |=] [+ [=| Ha |=] 1k + | Atelectasis” +11 5 Q Orp YMPNOCVTES fan aoge Bo DAGOOES E _ SAF “STEM” so2edS 1ejooA}Y| AEjoaniy Olonles fF Bactreriu apiifaries (4 p HANSFIOCYTIC els: atarr LeucocyrTes Lympnocyte origesrion Vitiphocyvres ongesrion IeraTOn 2 Fos wie nfiltratior: Yyperplasia o§ Wal) Cells LYVMpho cytes in : = HOmMmIUOLG _ SI9SS9A poolg ibe fo tebe aha fe Co ECPa ede ere Tirta et PERRET ERD af eda Beet TP epee faa lB] elo ba criti titi lch ele ih ae Endobronchitis necroticans: and Peribronchitis with intense swelling, No. 38°49. ' x bo Intense inflanmtory changes of peri- (left “wafer sy -) bronchial lymph-nodulus. ; Aoino-lobular, a Pneumonia. ; Sata. = _ tee (x 60) No. 4057 r Ma Eobular pneumonia, hemorrhagic-exudative. ( “ght a ery Bronchitis and Bronchiolitis | gravis, Bronchitis catarrhalis gravis, with massive desquamated epithediums. fons No 340 Ko Endobronchitis necroticans with | massive decayed masses, Endobronchitis necroticahs with | massive decayed masses, oy oh ‘ Pleuritis haemorrhagica gd Subpleural acuno-lobular pneumonia. Bronchitis catarrhalis gravis (with massive desquamated epitheliums) and Alveolitis of peribronchial tissues. * No, 4117, 7 X60: Edematous swelling and congestion (Left superior. ) ae of alveolar walls and some nee - ; . ; atelectatio alveolar spaces. oe ¢ t some karyorhextic masses, T be (A) Wieroseop, Investigation, I7, Slight submucous cengestion and no remarkable changes else, . 580, In crypts, some desquamated masses (fibrinous separations, serous fluids, some leucocytes, some decayed cells and some bacterial Masses) with slight localised superficial ulcers and severe cloudy or Dionecrotic swelling of mucous epithelial cells, ‘Considerable swollen follicles with some al ightly hyperplasieal ‘germinative centres, which have some swellen reticulum cells and - Slight congestion (especially remarkable congestion, edematous /ewelling and some bacterial masses in subepitheliar tissues) and considerable Jhyperplasia of endothelial cells of capillaries, ‘considerable congestion of other submucous tissues with sone round=-. cell-accumilation (some hitiocytes and some plasma~cella)s 388, . | In orypts, a lerge quantity of desquamated masses (fibrinous masses decayed cells, some leucocytes and some bacterial masses) with some t localised superficial ulcers and severe edematous or cloudy swelling of mucous epithelial cells. | Considerably swollen follicular tissues with some hyperplasied germi-~- native ‘centres, which have plenty of leucocytes, bionecrotically . swollen reticulum cells and some karyorrhextic cells, Considerable — multiple remare kable Deanvehingen and some leucoytes a ation in follicular and. -eubmucous tissues, 399, A large quantity of desquamated masses and severe bionecrotic or wearers swelling of mucous epithelial cells, Remarkable congestion of subepitheliar, peri~ and intra-follicular tissues and remarkable leucocytes -emigration in subepitheliar tissues and others, | Considerable hyperplasia and swelling of germinative centres with intensely swollen reticulum-cells, “fibers, and partial slight . hemorrhages, accompanied with considerable hemorrhages in perifolli- ocular tissues, ~e Remarkable congestion and remarkable edematous swelling of submucous . tissues, 396. Remarkable edematous swelling end localised superficial ulcers . of mucous layers with some desquamated masses (fibrinous separation,” some leucoe and lymphocytes, massive decayed cella), Remarkable congestion with » me bacterial masses as capillaries contensts ) and remarkable edematous swelling of follicular tlesnes : with slightly swollen derminative centres, ‘Remarkable songestions (with mme bacterial masses), remarkable seth at : edematous @welling and slight increase of pestecor tse: cells in other submuocus tissues. 397, Considorable edematous swelling of mucous anus wan © ne ——- . ae Gesquamated masses, Considerable congestion and edematous swelling of folliculer tiecies with. remarkabl inoreased, but remarkably awollen germinative centres, which have some increased, cloudy sowllen reticulum-cells and karyo~ . rrhextic masses, . Gonaiderable congestion, slight localised hemorrhages and edematous swelling of other submucous tissues. 399, Some desquamated masses (fibrinous separations, some leucocytes, erythrocytes and some bacterial masses) and edematous swelling of mucous tissues, Remarkable congestion (with some lymphocytes as Capillary contents) in subepitheliar, peri- and intra-follicular tissues and considerab= le hyperplasia of germinative centres with some increased, but cloudy, swollen reticulum-cells, some lymphocytes and some leucocytes (and plasme-celle). ‘ Some plasma-cell-accusmulations at perivascular parts of submucous tissues, with remarkable congestion, _ 403, : Remarkeble bionecrotic swelling and multiple diffuse superficial 7 ulcers of mucous layers with massive Aesquamated decayed cells, . The most intense congestion and edematous swelling of follicular tissues with rather atrophic germinative centges, which have some bionecrotically swollen reticulum-cells and karyolytic masses, Remarkable congestion and edema of submucous tissues, 405. _ Some a », bome reusceytes iw as . and some decayed epithelial cells) and slight localised superficial eee ulcers, , rie Se Slight congestion end edematous swelling of follicplar tissues with © some swollen germinative centres, which have some increased, pat . remarkably oloudy swollen reticulum-cells and some karyorrhextic masses, Slight congestion in other submucous tissues, 407, Without significant desquamations and uloers-formations. Remarkable congestion and edematous swelling in subepitheliar, peri- and intra- follicular tissues with some hyperplasied, but edematously awellen germinative centres. Remarkable congestion and diffuse hemorrhages of perifollicular tise. UO, _ 409, Cystic dilatation of lacunal spaces with a large quantity of serous fluids, some leucocytes and decayed cells and sevete edematous swelling of sucous tissues, . The most intense congestion and edematous swelling of subepithelier ~~. capiliary-plexus, peri- and intra-folltcular tissues with some hyperplasied and swollen germinative centres, which have some swollen feticoulun-cells and some karyolytic masses. Remarkable congestion and edematous swelling of submucous tissues . with slight perivascular round-cell-infiltrations. 4II. . Severe desquamation with a large quantity of decayed epithelial cells, serous fluids, some leucocytes and some bacterial aaueen; my Remarkable congestion end edematous swelling of subepithelier, . peri= and 4ntra-follicular tissues with some leucocytes= emigra> tions, esp. in subepitheliar tissues and multiple diffuse remarkable : hemorrhages, Oo Lymphenodulus in solid-form (with slightly swollen germinative centr- es) and some plasma-cells in subepitheliar tissues, 412, The moat intense, bionecrotic awelling of mucous cells and some dacterial accwnulations (intrusions) in intercellular spaces of mucous epithelial cella and in lymph~capillarios of attached sube- Pitheliar tissues. 412, : The most intense, bionecrotis swelling of mucous cells and some bact= eriel accumulstions (intrusions) in intercelluler spaces of muspus | re epithelial cells and in lymph-oapille ries of attached subepitheliar tissues, o Massive decayed masses (some leucocytes, severe serous exudation, fibrinous separations and some decayed epithelial cells) and the moat intense congestion and remerkable edematous swelling of follicular tissues with some hyperplasied germinative centres, which have some.” bionecrotically swollen reticulum-cells end some karyorrhextic masses and at sane places sane bacterial accumulations, ae ie Remarkable congestion and remarkable edematous swelling of follicu= lar tissues with mme leucocytes~emigrations, . 413, . " Slight desquamation “ines: of: mucous tissues, * red ee a Henne ———————= Considerable congestion and edematous swelling of subepitheliar, peri-and intrafollicular tissues with some hyperplasied and swollen. germinative centres, which have some swollen reticulum-cells (ane ; -fibres) and some karyorrhextic masses, Considerable congestion of prifollicular and submucous tissues. 417, Some deaquamated masses in crypts and bionecrotic swelling of ‘mucous | eplthel cells, The most intense congestion and edematous swelling of subepitheliar, peri- and intrafollioular tissues, Remarkable perifollicular diffuse timoeidienes (with edematous swell- ing) and remarkable reduction of follicular tissues with some, bacte= rial acomlations at some places, Slight hyperplasia and swelling of germinative centres with so me bionecrotically swollen reticulum-cells and some karyorrhextio ; masses, accompanied with considerable congestion of oapillaries in georminative centres and remarkable deminution of lymphocytes with some leucocytes-acoumulationsa, aes (Le oe Accordingly the common changes in all cases are as following: = In orypt: | . , Massive desquamated masses in all cases, except in I case, (serous fluids, fibrinous separations, some leucocytes, some decayed epithelial colls and some becterial masses, Sometimes some erythrocytes). - In mucous epithelium: With atrophy . in 6 cases, With remarkable or considerable congestion snd edema, . . , in all cases, With pionecrotic awelling,. . in 4 cases, _ With superficial ulcers, — | in 5 cases, In I cases (412 cases), I have investigated an intrusions of bacterial masses in interepitheliar spaces: tonsilla as entranoé~por b. of pacteria, | we In gérminative centres: Generally with reactive hyperplasia. , . in almost cases, {Sometimes di sappeafed) only remained Karyolyticcells, 4 cases, . The border of Wollicles indis tenctly 5 cases, pyalinote smuling 4 cases, — Sometimes with bionecrotic swelling of slightly increased . , 7 _ reticulum-cells, in 4 cases, With some leusocytes~emigrations, . in 8 cases, ‘In folliculer tissues: 7 - -_ “ie. es Set tory, changes in the follicular tissue ' Reactive considerable or remarkable congestion and edema, in all canes, In perifollicular. tissus: , Reactive considerable or remarkable congestion and edema, in all cases, With some hemorrhages, in 6 cases, With some bacterial accumlations, in 2 cases, With some bacterial acoumulations, in 2 cases, In submucous tissues: Sometimes inflammatory changes spread to the neighbouring aubeu- cous ‘tissues intensely, | With considerable or remarkable congestion, edema and hgemosshoge in all cases, With some hemorrhages, in 2 cases, rétiarkeb Ly hemorrhage in 3 canes, : With. mme leucocytes~emigrations. in TI. ¢ase, remarkably leucoixte-emiyuration. in 3 oases, With some round oe1] disseminations, in 4 cases, 3 Wi gn distributed hacteria, in cases, Aosordingly the main pathological pindings of tonsils are-as follow ‘ Remarkable swelling and come tinea bionecrotic awelling ( intrusion ae of bacterial masses), accompanied with multiple necrotic ruins or : ulcers-formation of mucous epitheliums and following some inflemma= : with reactive hyperplasiis of. germinative centres (sometimes a... es of hyperplasied retioulum cells). These inflammatory changes spread into the priféllioular of ‘aubee- pitheliar tissues with severe congestion and sometimes leucocytes= emigrations end propagate themselves furthermore to the neighbourin, submucous tissues with some inflammatory signs, Therefore tonsil is one of the main entrance ports of basteria, Intense congestion and intense aes. edematous swelling of follicular. tissues, In high power. With some bacterial masses in Capillaries. pa Vosere e iy Intese oengestion and some hemorrhages in follicular tissues, = ’ Intese congestion end diffuse hemorrhages #m follicular tissues, Intense’ necrosis of epitheliar layers. Necrosis of epitheliuns, gees leucocyte “Congestion fo elastorrhexis (hog oN M. propria-”. gland ineveared conective tise cell wv histrocyte . hemorrhage ~-*- severe deqonerat, o nectosis 5. ald ai oe 4 BRON CHU S, A) Microscop Investigation , he 54, Slight edema in mucous and submucous (at perivascu- lar portions) tissues and slight congestion with > slight degeneration of mucous epithelial cells. 225. be Ba. Mabe pace a: Slight atrophic mucous epithelial cells with eome degquamations, Considerable Meusboyeea=and Lymphoeytea-ent gration in all layers. esp, in submucous and inter-glendulaer tissues, Slight congestion, 7 _8ome degenerative changes of mucous epithel cells . end some sero-mucous secrets with desquanated 3% @pithelial cells : Epithelial cells with pyonosis, keryorrhexis and infiltrated with some round-cells ae Nace ie Pare (CARS2 > aD ane some erythrocytes or their fragments, ; a ‘ Slight round-cell-infiltration ing subm¥if. 0 or. interglandular tissues (atpophic glandular cells}: and considerable congestion, 4 393. | ~ a ° + @ Po mucous aud submucous tissues with some round sells Intense edematous swelling (eldstorrhexis) of Fe (mainly lymphocytes )-emigration in submucous or interglandular tissues, ; . oe Collaese of glands : epithelial cells with somewhat phonosis and karyorrhexia and infiltrated with some round-cells (mainly lymphocytes), due to hyperplasia of lymphatic nodulus, Considerable edema and slight round -cell-infiltra- tion in subepitheliar or submucous tissues, — re . Dissociation of cellular arrangements of glands, Slight peribronchiel hyperaemia, 400, 7 : : - Considerable congestion (with some leucocytes as capillary contents) and considerable edematous swelling of mucous or submucous tissues, Pass Some round-cell-dissemination in these tissues, < Intense desquamation of epithelial cells, due to... remarkable edema in mucous tissues. Remarkable congestion and intense edema in submucous tissues with slight round-cell-disseminations, — | Glandular cells are dissociated, due to edematous Coe 153 ce awelling and infiltration of some leucocytes, Peribronchial tissues with considerable congestion... and some localised hemorrhages, : 405. _ Sea an -Rather anemic, and no significant changes in mucous tissues, as Diffuse lymphocytes -infiltration (hyperplasia of lymphatic nodulus) and some hypersecretion of the glends, 409, Considerable desquamation of epithelial cell edematoua swelling of mucous tissues, srfarkable accompanied with Considerable desquamation of epithelial cells and ; Severe edema of mucous tissues, Remarkeble congestion (with some bacterial masses as sapillary-contents) ' and considerable edema, accompanied with some . leucocytes-emigration in mucous and submucous tissues, TE ae oe e Some atrophic glands and some lymphatic nodulus’ in glends, froth ie a, de rit RPeribeonchial tissues , with remarkable edema and coneiderable congestion, “4Tr, . Desquamation of epithelial cells and considerable BD qe » edema. of micous tissues, Considerable congestion Oo. some edema) and some localised hemorrhages 2D tn submucous and periglandular Usanen:, Atrophic és Beare 4ta.°7 ce Lo. = sei s. Some desquamated masse. {serous sesreta, some ez, F 50 -@ desquamated epithelial cells, some lymphocytes, “ce e S © “J « - ete.) and considerable edema of micous. tissues, Remarkable congestion in all layers, esp. in ie ( Og, submucous and Periglandular tissues, Peribronchial tissues with some hemorrhagic-exudative changas, Q «418, . Peribronchial tissues with considerable congestion . and some edema, 7 417, , Some -desquamated epitheliuns, Considerable conges~ “ tion and edematous swelling of mucous and submious tiene. Some lymphatic nodulus among the glands, teks CRE, 3B). SUMMARY. (I) The dvird's-eye-view of pathological changes in all cases, a a enn Nan Nene eS eee) Considerable congestion and sone edematous swelling of submucous Slight edema in mucous and submucous tissues, Slight congestion and considerable leucocytes dissemination, Remarkable disturkances of mucous tissues, and considerable corgestion in subrvcous tissues,accompanied with some ) Tound~ cell gissemination, Intense edematous swelling of nucous and. submucous tissues with hypofunction of glands, Considerable edema in submucous tissues, Slight peribronchial. congestion, Sonsiderable congestion (with some leucocytes ) and edema in submucous tissues. Remarkable edema of mucous tissues and-remarkable congestion and intense edema of submucous: tissucs. Some leucocytes ~emlgra~ tion in interglandular tissues, : Peribronchial tissues with considerable congestion and henorrhages. No significant changes, Remarkable corigestion (some bacterial masses in capillaries), considerable edema and some leucocytes -dissemination in submucdus, Sach adane er tissues with romarkable c€ema. and some congestion, Considerable congestion and some hemorrhages in submucous tissues, Remarkable congestion in submucous and periglandular tissues, Peribronchisl. tissues withg some exudative hemorrhagic SnENEP Es ae Peribronchial: tissues with some pomoreheeess pene: (2) ‘I divide all cases into 2 groups : a) group of peroral infection énd © >) pernasal infection, : ; '. a). Peroral Lufection with no siguificant bronchia2 and peribronchial changes, ( for examples, No, 54 and No, 225). b} Pernasal infection, luvestigated all cases, These are accompanied with some exudative changes, Considerable acute congestion and edema, in all casos, Items : with slight exudative changes, ; 2 cuses, with considerable exud, changes. 5. cases, with remarkable exud, changes, 3 cases, with slight hemorrhages. 4 canes, dents with some leucocytes -emigrations, - 6 cases, aoe with bacterial masses as capillary contents, : = , I caseg, aH ({§with some peribronchial exudative changes (not investivgated © _ dn all cases), some cases, _»%n all autopsical cuses, intense diftuse mediastianal hemorrhagice : exudative changes are recognized (also by X-ray tests, clinically). " | These.autopsical cases are nor investigated micrvscopically.in all cassea, while I have nor recieved all microscopical materials, ~Someé bromchial dnd peribronchial changes with congestion and' edems® in submucous tissues are complications 2° these main pathological fidings. ‘Therefore the main pathological changes are Medistinitis and Peribron- ohitis haemorrhagico-exsudativa, (3) . Accordingly the general sketches of pathological changes are as . following 3 ME i Irteucooytta hemorrhagic changes in submucous tiasues. iy, 30! BORERETHS es dBha tration in ¥ gO M343 Multiple localised h in submucous tissues. ~ 10e apparatis Ye subsueee x90 emorrhages BEE euee. geet to A Leucocytes inftltration in ” +09 nah eeean: Leucocyted infiltration around { the outer tube of gland. . ne? 1 BARR, arr aeg8 265ud SEES pene pee paren Kage ” Incrasased Leutocytes Saye: Jecreased Kuplfer’s calls Degeneration Hy Hemorrhage Fatty degeneration t be---s* Hem orrhage. op Miltary Knot atlcessessedes: Hilvary Knot ‘Bactlus -embolus ~ Round Celli inftitration Pseudo tubulus 164 — “or less increased histiocytic cells, with remerka= changes arborescently te. the perifocal tissusy Li. v E R. (A) Microscop. Wowie’ Hepatitls serosa II,. with considerable exsuda= tive changes in Disse's spaces and considerable . diffuse fatty degeneration of parenchymatous © Celis - 26. ; Hepatitis serosa III, ; ; Parenchymatous degeneration and atrophia, caused by extremly | severe congestion with partial hemorrhages, esp. in the central zone cae actauses ° (severe congestion, exudative changes. in Diasera ct spaces, partial hemorrhage and increased lymphe- cytes as capillary contents), And maltiple miliary knots in acinuses, which .— are formed at partial hemorrhagic places with - 0%, wandering-cell accumulations. In the focus of «~” knots exist plenty of lymphocytes, some resiviaual masses of. decayed parenchymarous cells and more - ble pgudo-tubulus formations, These seata are bounded not-sharply and spread with exudative). 8 53. Hepatitis serosa II, : Parenchymatous degeneration with more or less considerable congestion and multiple submiliary portions of acinuses, which are formed by some lymphocytes and slightly histiocytic cells, accompanied with pseude-tubulus-formation in slight degree, 54. ; : : Hepatitis serosa, At,--1It. — Parenchymatous degeneration with considerable con- gestion and slight partial hemorrhages, esp. in the central zone of acinuses, 225, Hepatitis serosa, III, - More or less cloudy and fatty degeneration of parenchymatous cells, Dissociation of cell-arrangements, which are caused by congestion with slightly ineveased lymphocytes as capillary contents, 318, ; Hepatitis serosa, III-Iv, More or less remarkable showy and. fatty degener gi tion of parenchymatous cells and disscetétion of cellular arrangements which are caused by severe" . congestion (and increased wandering cells as ca-. pillary contents) with slight partial hemorrhages, (esp. in central zone. of acinuses, ) 320. ' Hepatitis serosa I-II. Parenchymatous degeneration with slight conges - tion, exudative changes in Disse'’s spaces, sligh- tly increased lymphocytes as capillary contentss’ and more or less panatbable increase of Kupfer's cells, Slight bihous stagnation in acinuses and Glissons capsules, . 525. Hepatitis serosa II, ; ; " Parenchymatous degeneration with slight congestion, hemorrhagic -exudative changes in Disse's spaces and slightly increased Kupfer's cells, 383 . Hepatitis seresa III. Severer exudative changes than 325 -case, 388. ; Hepatitis serosa II, 389. ; - Hepatitis serosa III; a . Remark: tous degeneration with | [ae ; 16s _ we. oa with severe congestion and seyere hemorrhagic= exudative changes (remarkable hemorrhages in central zone of acinuses, increased lympho-or leucocytes as capillary contents, edematoug swelling of capillary-walls and serous exudation). Hepatitis serosa II-III, 396, Hepatitis serosa II-III, with sient per icapillar leucocytic cell accumulations in peripheral | or marginal parte of scinuses (proportionated to the initial stage of submiliary knots-formation in No. 397-case), : Poat mortal change in this specimen, 397, Hepatitis serosa III, with multiple submiliery. ~ knots, mainly in peripheral zone. of acinuses, which are formed by slight accumulation of —s lymphocytes and some decayed masses of parenchym- atous cells at hemorrhagic places, Post mortal change in this specimen, a _ 399, im aa s . Hepatitis serosa III-Iv, | Remarkable congestion and remarkable exudative changes in Disse's spaces, with some wandering cells in capillary-neta: and maltiple henorrhages. in acinuses (where fall into necrosis), is 400, ; Hepatitis serosa II, es . Slight congestion and slight exudative changes in Disse's spaces, with considerable cloudy swelling and-slight fatty degeneration of parenchymatous é cells, ; ; Intense congestion in Glisson's capsules, 403, | Hepatitia serosa II-III, wi th bacterial emigra- tion in caplllary-nets in acitnuses, 404, Hepatitis serosa IfieiIv, : Intense exudative changes in Disse's spaces with intense dissociation and some cloudy degeneration , of parenchymatous cells, 406, ; , Hepatitis: serosa II-IIl. ne ; gees In acinuses ofecured so-called some net -necrosis with are produced by falling into the mltiple ‘localised- moliary or submiliary knota, exsisting mainly ral zone of acinuses, : a iain ‘7 oS Pa Git These net-necrosis are formed by some degenerated: parenchymatous cells with net-Likely clarified glassy protoplasma and their decayed fragments, accompanied with slight bils-pigments, Situated at the hemorrhagic places, ; In other general tiation of liver : cloudy serlling of parenchymatous cells with more or less exudative changes in Disse's spaces (Hepatitis serosa III.) and slightly increased histiocytic cells, . 409, . Hepatitis serosa II-III, with bacterial deposits in capillary-net in acinus, | 410, Hepatitis serosa II-III, with severa congestion and partial hemorrhages in central zone of acinus- es. Cloudy swelling or fatty degeneration of : parenchymatous celle, esp, at hemorrhagic parts: ' Edematous swelling of Glisson's cepsule with - slight round -cell-infiltration and pseudo -S4liary- tract formations, 41i. Hepatitis serosa II-III, 414, Hepatitis serosa II, with remarkable exudaltive changes and considerable congestion, 4I6, Hepatitis scrosa II.-III, 4t7 Eepatitis serosa II.-IIL. with severe “congestion, and exudative changes: in, Disse's spaces, Multiple submiliary knots in acinuses, which are formed by accumulation of some leucocytes, a little lynphoeytes end histiocytic cells and decayed masses of parenchymatous cells, (B) SUMMARY The bird's-eye-view of pathological changes of liver-tissues in all cases ee following: A) Acinus : . I) According to these results I classified the parenchymatous disturban- ces of liver tissues ty Anthrix-Cisease .as followed ; Hopatitia serosa Ze. 1 Causes. bi Il. 15 cases, " III. 9 cases. " Iv. 0 cases, with hemorrhages (esp. in central zone of acinus).(a.9 cases with miliary knots, 5. cases 2) Generally wore or less considerable congestion, ‘ In medium degree. ‘% Ain cases of them, In severe degree, _ 5 in casos of them, with hemorrhages in central cone, 9 in cases of them, — 2) And more or less cewarable exudative changes in Disse's spaces, In slight degree. 8 cases, Ih medium degree, 5 cases, In severe degree, 3 cases, 170° 4) In proportion to exudative -hemdrriisgic processes, occured more or less considerable parenchymatous degeneration and dissociation of cell- arrangements, Generally with cloudy swelling, esp. at hemorrhagic places; With remarkable fatty degeneration in ‘§ cases. And I case (Yo, 407) is eccompanied with so-called net-necrosis in peripheral zone of acinus, These necrosis are formed at hemorrhagic places by cell-groups of some degenerated parenchymatous cells with net-likely clarified protoplasma or their Gecayed masseg, succompanied with slight deposits of bile-pignents. Occaisionally emigration of some lymphocytes or léucocytes as capill- arycontents and furthermore formation of multiple miliary knots, caused —. by accumulation of wandering cells, esp, in the peripheral zone or intercalary portion of acinuses. Cc With peancrkablé {Ineréasod. wandering cells 3 cases, as capillary contents, ; : STight pericapillary leuscoytes -accurmlation ‘in. periphéral zone of acinuses: pe J (initial stage of miliary -knot sformation), 2 cases, ‘Multiple miliary knots, ‘5 cages, ~ Remarkably increased wandering cells in capillarz-nets gathered to: form. pevicipillar accumulation, esp, in the periphcral veiie of acinuses,:: cv And frequently These changes into multiple miliary necrosis, which are formed by some hemorrhagic masses, some leuco-or lymphocytes and some residual masses of decayed parenchymatous cells Bats . Sor and occaistonally spread moreover with hemorrnagic-cxudative changes to the perifocal tissues, “With the lapse of time, 1n some rather rroliferativo cases (No, 26, 53, 410 and 417), thepe are accompanied with slightly increased histiocytic cells and frequently pseudo-tubulus-formations, B) Glisson's capsule, :_ Generally slizht edema, I2 cases of them in more or less considerable .degrec and slight round-cell-infiltration, 2 of them in more or less sevore degree, Occaisionally slight diffuse hemorrhages, 4 . LIVER eT PEEP GEER REED Rep PEE) SES SOOM MESS OD SS Ecole SUAUSEES"GRAGRRECROACCRGECCHAANAE éestion ra, = Dilatation 3, gsociarion a EucocyTes Quding: N ‘Fatty, [Edema | __H Se und Cell Intitrario rd S19019N AlettIw 1) Airophia [._WyPpertrophia centra Deséneration = : de: Pig . V. cemtratis ton ‘ pilai atid ——teucocevres yl __Lympnocytes =-dema Kuplter’s Proliferation dels nemiasider | _pacterium | Lone V pa GUC ¢ PSeudobiliary ‘tract (es) 2 vy $ b=) 16 2 mies) ’ [Gen TirresularArrangement Garg SES ESE EE SEARED FT PRE ET BSE ai HEUER mec EPEAT ED ESP CU ESOT Ve TUES PST ESE TSS ‘By Se TL ELT EEE + SHH TT A Ea EEE SI + (41-1 ode ta [+ +] coco wloci x ement. ular Atran rre LIVER nA Ci __Heniorrnase —— . "5 Proliferation | _ SENS. emosiderin Production# Connectiv Tissuete Pseudobiliary tract a =" (7 Se & "Hemorrhage [ROunG Cell Infiltration ~, Intense congestion and remarkable ', oxudative reaction in Disse's spaces. . 2 Intense congestion and some nenQunneele in the Generet zone of acinus. VIS Hepatitis serosa with intense exudation: «in Disse's spaces and anbanse Parenoorey degeneration. Hepatitis serosa with intense exudation’. in Disse's. spages and intense \ parenchymatous degeneration. ares Ste: xfer ICR, ae ta Hemorrhagic necrosis. Hepatitis serosa in severe degree,. in high power. 177 Our so-called net-like necPosis in ee acinus. vur so-called net-like necrosis in acinus. : : ' Diffuse wandering cells dissemination. . aa Submiliary necrosissvith some lymphocytes accimulations. A4 ¥/7 422 Hepatitis serosgIII,with sone exudative chagnes in Disse'ts spaces. Degeneration ie Edema H Congestion : ore saee Roundcell wifiltration: ; Degeneration . Hemorrhage’ Seal ag blood vessel. wail --- Bacterial. masses * Necrosis: .2-.522... ; aes Ce Dba Degenerat zon = QT AEB Degeneration Degeneration STOMACH, (4) Microscopical Investigation, I7. Slight submucous hyperaemia and s¥paration of areas epitheliums cella, , 54. Slight catarrh, (225. Considerable stasis in T. propria and T, submucosa, 316, ee eatarrh of mucous membrane and considerable congestion in T. submicosa, ae 320, Slight catarrh and considerable congestion in T, propria and T. submucosa, ; 390, Gastritis catarrhalis hypertrophicans levis, 596, Slight edema of nucous wembrane ~. ; 397, Slight edema and slight stasis in T, propria, 399, Almost normal, . 400. Considerable catarrh, . 401. Slight catarrh, : 405. No remarkable changes. 406. No remarkable changes, : 409. Slight stasis in T, propria, 410, Slight stasis and slight catarrh of mucous membrane and considera- “ dle eeanie of T, submucosa, 412, slight catarrh of micous membrane, 3 41S, Slight catarrh and slight hyperplasia of macousk membrane and eg y 414, No fo.aiikable changes, | 417, Slight edema and considerable stéis of mecous membrane and slight stasis of submucosa, (B) SUMMARY,.-: @enerally without any significant changes in all cases, All observed ; ; 19 cases, with slight catarrh, perhaps due to peroral infection, DEON gt 2 he og / 1O:Cenes. with slight congestion, : 5 cases, with considerable congestion, 14. cases, with no remarkable changes, _ ; 3 cases, with rather atrophic glandular cells. Q cases, D Bess SMALL INTESTINE ; (A) . Microscopical Investigation, - & 17. Extraordinary sogere marrowy @welling of mucous membrane with the severest perifocal haemorrhagic exudative reactions, = . ; In the areas of swelling exist the severest edematous swelling, sen verest, congestion (bacterial masses in blood -vessel and severe edema~) tous swelling of capillary-walls), more or less reuerkable hemorrha~_ ges and numerous leucocytes-emigrations, Glendular cells at these perts fall into decayed masses or Gisappeared totally, and at the murfaces of these parts exist in a large quentitiy of separated masses of desquamated epithelial cells, bacterial masses, leucocytea=. fragments and ex@udative -hemorrehgic: masses, These leucooytic ~hemorrhagic inflammations propagate. themselves ‘ell _ over the neighbouring tissues (T. submucosa and perifocal mucous © tissues) with severe exudetive hemorrhagic processes, Sess ‘Perifocal maceus membrane in severe edematous swelling, severe. gestion and more or less remarkable hemorrheges with severe oaterrhe: lic masses, . sf : be : T, submucosa in diffuse edematous swelling in high degree, severe congestion (bacterisl masses in bloodevessels), and perivascular leucocytes infiltrations, | : . (88) : Catarrh in medium degree and stasis of mucous membrene and, consie . derable oengestion of T, submucosa, 226, GH rome ar [eeueeores tS Wg Jajinciugion | pgiceiqccelsE |= TL 5 Endotneliuin TResolupod lade | 1 | = IPhABOCY Set ae lemma ‘ et || jj __N Nee i rn. TE q fH ida tH d : I-|—|-[# it i at “et ee He S =| 3 ii Pe] TE T+ EPEAT POMaGie Angio-folliculitis exsudativa . Edematous swelling of central artery waal. ; Some leucocytes dissemination, some edematous swelling and some increased reticulum cella ( in histiocytes-form).. Angio-folliculitis exsudativa. E,ematous swelling of central artery wall. Some edema, some leucocytes and some increased reticulum cells ( in macronphagen-form). : Hictiweytes M 3k 2/o - Follioulitis exsudativa, with hyalinous swelling of central artery and intense edematous swelling of follicular tissues, Follicultis exsudativa, with intense dionecrotic changes all over the follicular tissues and intense edematous awelling of central artery walls. x /ve oe dyaline droplets in sinuses, Hyalinous swelling of central artery j tab habeas « X 263 MAL of central and erteries wall, . . ce? ! au Folliculitiw haemorrhagica, with some hemorrhagic chamges om follicles axi sme henorrh, ges at perifollicular portion . Folliculitis haemorrhggica, with some hemorrheges in follicle and perifollicular tissues. coe : ae Our so-called Angio-folliculitis Shep haemorrhagico-exsudativa, with t GQiffuse edema and hemorrhages in germinative center, Edematous swelling of wall of penioillar artery. “Intense edemat # Bwolling and necroti ~gpgsnes 3 foliioular tis Wes, esp. . around peniciller artery. . oP ad Cea Angio-folliculitis exsudativa with ae ‘gome increased reticulum cells -( in macrophagen-forn). Proliferative reacbion at polar portion. some increased reticulum cells. tet Swelling and slight hyperplasia reaper pone fibres at peri- oll Proliferation of reticulum cells at perifollicujar portion, our. aqsenlied dnsherfehiionisie _wadetire, accompanied wt th many, fikercnded retieulun welie, Biweabous, ewelling of sentral artery aol ewelling, sone @ ameener tsa retdien saa" Feo eehie ‘in foliieuer Sinus, Degeneration Bacterium Peripolay edema Peripolar change (Deg) ” , (Necrosis) —Vacuolar degenevat. Hyaline cylinder ~ Atrophy # tubulus . d Interstitial edema Lyw he € as 2 . mists : — ; Som Capillar Hemorrhagey aoe Cirrhotic change aes eae a ea wi eat biein of tiring Pow es aE nISoNE Y. (A) Microscop, Investigation. 17. vonsiderable Glowcittenephrosis’ (glowerulus Mainly ia rather degenoretiive ford), with slight our so-called peripolar changes wd Nephrosig in 3 I. stage, at some places in iII..stage with hemo- rrhages, eo, . Slight Glomerulo-nepnrusis (nainly in neute hyporcule form, sone in degenerative form) with ae slight our soetet tea neripoler changes and Nephvosis La IT. stuge with slight, at some places remarkable interstitial odema, 54, ot rae Slight Glomarulo-nopirosis (maihly’ in degenera- tive form) with slight peripolar changes and Ne= “ phrosis in I. stage with rather atropiiic glandular cells, and at some places remarkavic vacuolar Uegeneration of glandguler cells. GSonsiderable interstitial edema and slight - elrrnotic chences with slight increase of conne- etive tissues at subcapsuler portions. =; sg ’ z fa se ol aoe ny DS Res: : ) £25. Sonsiderable Flomeralo-nephrosis (mainly in rather Cegsnerative-form), Some glowecular loops ard Bowsan's capsules in hyaline degenera~ tion, with cousiceratle our so-called peripolar changes. Nephrogis in i. stage and at some places in Tir. stage with some ayuline-droplots -degeneratious. Conside*able intertitial edema and slight cirrhoti shenges of interstittcl tissues with some Lerge hyzline eylingers a6 some places, and some necrotic desolation of tubular epigheliums at some places,’ 212, : Slight Cloueeulo-nerurosts (mainly in acute hyperemic forn, some glomeruli in nyéline clrrhaoce sis) iand Nephrosig in I. stcge, at some pleces in Lit, stage wlth sone round coll -eccuuwaulaliens and considerable edewa in interstitiel tissues, Considerable. Gt o..crulo-nephrosis (mainly in acute exudative form) with slight our’ so-called: peripolar changes ane Nephrosis in I. ‘stage with consiceravls, 2t sone pleces remarkable : interstitial edean (Nephritis serosa}. Ags Consiceravle Clonervut (mainly in acute stinulises form and seme gromerait in desenerativs for) with slight our so-called peripolar changes sud epurosis in I. stage with — considerbl., interstitial edema. 223, Slight Glomerulo-nephrosis (mainly in acute hyveremic for.r, some in degenerative form), with slight peripolar changes and Nephrosis in I. stage with considerable interstitial edema and slight necrotic changens of medullar capillary walls, Slight Glomerulo-ne~hrosis (mainly in degenerative Soria) with slight pecipoler changes snd Nephrosis in I, stag? and at some places in III. stage with considerable, interstitial edema and hyaline-_ necrotic changes of tubulus contortus I. 39, Consideravle or slight Glomerulo-nephrosis (asinly in acute stimulised form) with slight. peripoler changes and Nephrosis in I, atage, at some places in imt, stage with considerable interstitial ' ee. 4 596, Slight Glomerulo-nephrosis (mainly in degerative form) with slight peripolar change and Nepbosis in I, stage, at some places in III, stage with consim 7 derable interstitial edema, accompanied with some leucocytes as capillaries contents, Slight Glomerulo-nephrosis in acute stimulised form with some bacterial and fibrinous masses in glomerular loops and slight peripolar changes. Nephrosis in I st stage with considerable inter- stitial edema and some round cell-accumulation. in interstitial tissues, Glomerulogenous erytherocytic cylinders in tubular spuces, Slight Glomerulo-nephrosis (an stimulided form) with bacterial and fibrinous masses in glomerular loops and slight pertpolar changes, Nephrosis in I st stage, at some places in III rd stage with considerable interstitial edema, Slight Glomerulo-nephrosis with slight peripolar changes and Neptrosis in 1 st or at some places in III rd stage with considerable tnterstitial edema and some round -cell-accumulations at cortico-medullar boundary, 405, Slight. glomerulo-nephrosis with slight peripolar changes and Nephrosig in I et stage with extremly : severe vacuolar degenerations of tubulus contortus I. and considerable interstitial edema, 407, Slight Slomerulo-nephrosis with slight peripolar changes and Nephrosis in I st stage with considera- vdle interstitial edema, 409, . Slight Glomerulo-nephrosis with slight peripolar | changes and Nephrosis in I st stage with sonsideve= ble interstitial edema, some round-cell-accumulation 8 at some places and miliary cirrhotic portions in cortex, 411, Slight 4) omerulo-nephrosis with slight peripolar changes and Nephrosis in + gt atage with considera- dle inters extremly severe vacuolar RSS 4 degeneration of tubular epitheliums at subcapsular portions, 412. Slight Glomerulo-nephrosis with slight peripolar changes and Nephrosis in I st or at some places in III rd stage with e onsiderable or remarkable interstitial edema, . 413, ‘Slight Glomerulo-nephrosis with slight peripoler changes and Nephrosis in fi st stage or at some places in III ra BUBBO 5. At some places, Nephritis interstitlalis subacuta with massive round cell accumulations, considera- ble edema and considersble hyperplasia of connective tissues in intersctitiums, Slight Glomerulo-nephrosia with s light peripolar changes and Nephrosis in - st stage or at some pla- ces III rd stage with considerable interstitial edema, is ne SUMMARY AY Tubular changes: |. iia | “Generally eocured more or less intense cloudy swelling of tubular “, epitheliums with some various cylinders in tubular spaces. 4 a ea Nephrosis in I, degree. 24 oases. in Il. degree. 5 cases. in III. degree. ; with some btoneorotic swelling, 2 cases, with some necrotic changes, 3 cases, All investigated 34 cases, Tubular contents: Protein- Hyaline masses, subst, in slight degree 8 0 4n medium degree 15 18 in severe degree I I _ : * B) Glomerular changes 3 Generally oocured some glomerular changes : Glomerulo-nephrosis, Randerath's, with some edematous awelling of capillary walls of q : ee aa Saas : i Pye? .glomerular loops, swelling or slight increase of and some serous ‘exsudation in Bowmann's spaces. Glome rulo-nephrosis : P in very slight degree ( )e 19 Cases. in,,2°.' " slight degree ( ). 4 cases. 4n medium degree ( ). I cases, Polar changes : ? ? in very slight degree. 10 cases, 4n slight degree. 13 Cases. in medium degree. 1 casea. 2 fe PG ’ 6) Interstitium. Generally with more or less intense edema, sometimes with some heemorrhages an@® sometimes with some round cell acoumulation in inter= sttiums. a ‘A fow cases with some signs of Nephritis interstitialis subchronica, — a Haemorrhages. | a ee ; cortical medullary tissues, in slight degrees 2 in medigm degree, te) in severe degree. ie) On polar changes 3 : ee: Our so-called polar portions of kidney fall e@ periglomerular areas at afferent portions of blood=vessels, bounded with 2 blood-vessels (V.afferens and defferens) and intercalary portion of tubulus and equipped with special cellular arraggements with neuro-myo-angio-q ~ epithetiar segments, which belong to socalled diffuse endovrinic system. These areas are very chemoreceptoric, and able to regulate blood-quan- tity in glomeruli and furthermore favorite-seats of various fnflamna~ tory changes. , Noxae, advanced hemotogenously to kidney, aause inflammatory changes firstly at afferent portions, due to their chemoreceptoric properties, then at glomeruli and sometimes at V. defferens. Thus occrued inflammatory changes angio-vasculally at perivascular portions in 4 ~areas. These noxae are filtrated at glomerular loops, then excreted in tubulus with nephrosis and some of them absorbed again mainly at intercalary portions of tubulus, accompanied with considerable dege- neration of tubular epitheliar cells and oe peritubular infla- maatory changes in neighbouring © -~areas. Thus occured inflammatory changes epitheliogenously at peritubular portions in 4 -areds. , A -a@reas are very sensitive to inflammatory changes, which occured in 2 manners,a) angiovasculally at perivascular portions with mesenchymal, reactions and b) epitheliogenously at peritubular portions with epitheliogenous reactions and accompanied with various complicated changes, due to chemoreceftoric and regenerative properties of these ; . egies AGL : intercalary portions. In areas, inflammatory changes apt to be occured and if occured, | in 2 manners, not only with mesenchymal reactions, but also with epitheliogenous reactions. Such special cellular arragements with mesenchymal and epithellar segments which belong to diffuse endocrinic system, are expected to exist in each @rgens(for example, dicovery of "lung~island® by | us) and inflammatory changes of these portions are named by us "polar changes" af each organs. Ki DNEY LE cee Seay eee eee eee | walis [+ STEERER eter errr ae le seein — njents| Erythrocytes |e _K eee ries ROUNG. Celis - = powman’s .bilatanon |=] umen pine TI Penehranive juid J f+ Gna toudySwelhins. Hey Proliferation [4-1] Bowman's | _ Sweling [+1 apsules [Hyahnepegencranon| — | oeSueling— Prieto feraror pesauamariog | ‘LSwelling | iHyatineDegtneranory . j ST GOnGUE erentia ane HOGER RCOUE [peripoet Edona |e t= = Peer eat Ee eee eee BE eee eS macula Gesea T= aR eS eee ee Cougs suena (ein trtare is ereieteetelete tee ete te stare ae lyalirieDroplerpege (ea — [— [- [= [= [— i [| = [= |] [= {— [— || ||] Macuotar becereratton | ep Fatty Deseneration ae Tae sear fanaee pte “iHyalineeColloid ylinger [44 | — | Ve Hore cal urn Geers fate ee eerexta ESESESES(SESESEREACAE? Edema eae ae aaa nearest “rores eae tae : [ Hemorrhage, {Meduttal — t= I= == nicartex Tita [+ | ae: Intense exudation in Seusenn's epaces, © apoplexy or *ivpinous waeses sn @lomeralar loops. thrips § [oo Me aot tone “Lenercle-serhyeste with . Tryttoarten seylingers in tavales, In paresis with, Dienserndioc changes . f tumilay ¢ opitheliume. Nephritis interstitialis sub- acuta with some leucocytes accumulation. Degeneration Edema My Miliary Necrosis ‘ NS Hyaline one. Ji yf Hyaline Degeneranion cefe M ae rae Nese ul alee re: Degeneration "~ -Hyalinous Swelling « Autolysis.. 1.” Blood Vessel-walls Bacterium -.--f LS Autolysis - Farty Necrosis enka Siepeieraten -- Hyaline Droplets Degeneration Avoplexy ~~ #" Degenterati \ iA “Ma Hemorrhages egereration Cataryh vi ? Congesrion (Pdlar Edema.“ ‘Hemorrhage ‘ Round Cell infiltration “PANCREAS, _ ca Microscopical Investigations, 26, Venous congestion and edematouls swelling of blood~ vesselg~walls, Remarkable parenchymatous degenere> tion, some of them inv-acuolar degeneration, ; ae Considerable vacuolar degeneration of island-cells, «| 83. _ Slight venous congestion, slight degeneration of oe parenchymatous sells and island-cells, Hyalins” degeneration of blood-vesselsewalls in slight degree, 225, : ee 6 Considerable venous Congestion and slight edematous. swelling of connective tissues, Atrophia of peren=. chymatous celle and slight dissociation of cell= arrangements, Considerable degeneration of paren- chym, cells and island=celle, . Sie. Srignt Venous congeation end slight hemorrhages 4 an connective tissues, Siignt degeneration of parenchyn, celle and island-cells, Siignt catarrh of efferent ducts, im... 320, Considerable venous congestion, perivasculer rounde - cell-infiltration(some loucocytes, lymphocytes, plasma-cells and histiocytes) and perivascular ed- ematous swelling, a Cloudy swelling of perenahymatous cells and eeignaa< cells. : oes Remarkable stasis of island-capillaries and consi« derable hyperplasia of capillary=walls-celis. 328, = - re ae 4 Consid. venous congestion and edmatous swelling of connective tissues. Edematous swelling of blood=— voasel wells and slight plesooted ter of perenctym: cell -arrangements. “ Atrophia of parenchymatous cells and slight degenera= tion of parenchym, cells, esp. at perivascular portions, “onsid, degeneration of island-ceils, a | Pe venius congestion and edematous ole of connec~ tive tissues, Slight dissociation of cell -errenge~ ments and cloudy swelling of parenchym, cells and island-cells,- wh | | Stasis and slight degeneration of parenchymatous - cells, R70 io 403. ; . Considerable venous congestion, slight edematous swelling of connective tissues and alight hyalinous degeneration of bloodvessel -walls, . Dissociation of cell-errengements. and considereble degeneration of parenchym, celis and island-cella.s Caterrh of efferent ducts, 407. | Venous congestion and hyalins degeneration of blood-vessels-walls, Atrophia and cleudy suiting of parenchym. cells and vacuolar degeneration of islandecells, 409. . ie Edematous swelling of connective tissues and disso-~ elation of cell-srrangements, Biouay swelling of parenchym. cells and vacuolar degeration of island-cells, Considerable venous congestion, swelling of connecs tive tissues and slight perivascular round-cell+tne filtration, _ ; Se Atrophia and cloudy swelling of parenchym. celle and remarkable vacuolar degeneration of island= cells, ae. Swelling of connective tissues and dissociation of cell-arrangements. Sonal dereble degeneration of parenchymatous cells and considerable swelling or cloudy degeneration of island-cells, 417% . . | In autolysis, Vacuolar degeneration of parenchym. cells, ATA 17. Remarkable dinewstion with edematous swelling and nyalinous degeneration of blooa-vessel-wa~ lls. Atrophia and remarkable cloudy swelling of parenchymatous cells. 3 comsiderable vacuolar degeneration of parenchymatous cells -and island-cells. Kdematous swelling of connec-~ tive tissiues. slight fatty degeneration of parenchymatous cells. OSes slight congestion with edematous swelling and hyalinous degeneration of blood-vesel-wa- Lis. slight cloudy swelling and atrophia of parench ymatous cells. Considerable vacuolar degeneration of paren- chymatous cells and island-cells. Slight hemorrhages in interstitial tissues. 5256 ; Considerable congestion, perivascular round ~cell-infiltration (some leucocytes, lymphocy~ tes, plasmacells ana histiocytes), A773 Ba | Slight eaematous swelling ana slight hyaltious Gegeneration of blood-vessel-walls, and perivascular edema. ; Remarkable cloudy swelling of parenchymatous cells and island-cells. slight swelling of connective tissues. | Catarrh of efferent ducts. 588. Slight congestion, perivascular round«cell-=in« filtration (some leucocytes, lymphocytes, plasmacells and hjAstiocytes). sf Slight edematous swelling and slight hyalinous degeneration of blood-vessel-walls. a Considerable cloudy swelling of parenchymatous . cells and islamd~cells. 589. Remarkable congestion with edematous swelling and slight hyalinous degeneration of blogu-ve-= ssel-walls. ee ‘plight elouay swelling of parenchymatous cells and iglana-cells 3 consicerable vacuolar cegeneration of parenchymatous cells ana island-cells. Slight hemorrhages in acinous cells. Catarrh of efferent ducts. ; oe ies hae i s : : wee ee eg RY 7 $90. | In autolysis. Remarkable congestion with hyalinous degeneration and edematous swelling of blood-vesel-walls. - Perivascular edema. Remarkable swelling of connective tissuses. Remarkable cloudy awelling of parenchymatous cells and island-cells. Hemorrahges in island-celis, 397. | - Slight congestion with edematous swelling and hyalinous degeneration of piebawveusd eas.” lls. Perivascular edema. . es Slight clouay swelling of parenchymatous cells ano islana-cells. Conciaerable vacuoler degeneration of parenchymatous cells and islana-cells. Dissociation ana atrophia of parenchymatous cells. Fatty degeneration and diffuse hemorrahges in interstitial tissues. | Remarkable pyknosis of island-cells. mE .,. 3994 Slight congestion with edematous swelling and hyalinous degeneration of blood~vessel-wa- lls. Perivascular rouna-cell-infiltration, (some leucocytes ,lymphocytes, plasma=cells ana histiocytes). Considerable clouay swelling of parenchymatous cells and island-cells. Remarkable vacuolar degeneration of parenchymatous cells and island-cells,. Slight swelling. of connective tissues. Catarrh of efferent ducts. 401. slight congestion with edematous swelling and hyalinous degeneration of blooa-vessel=walls. Perivascular rounascell-imnfiltration, (some leucocytes, lymphocytes, plasma-cells and histilocytes). Considerable cloudy swelling of parenchymatous cells and iséand cella. Considerable vacuolar degeneration of parenchymatous cells and islana-cells. Arophia of parenchymatous cells. Slight swelling of connective tissues. Catarrh of efferernt ducts. ee, --. 404, slight congestion with hyalinous degeneration of bloodevessel-walls. Consicerable cloudy. swelling of parenchymatous cells and island-ce- lls. Remarkable vacuolar degeneration of _ parenchymatous cells and island-cells. Dissociation and atrophia of parenchymatous cells. Remarkable pycnosis of island~cells, 405. Remarkable congestion with edematous swelling and hyalinous degeneration of blood-vessel-wa- lls. Perivascular round-cell-infiltration (some leuc ocytes, lymphocytes, plasmacells and hiystio~ cytes). Considerable cloudy swelling of parenchymatous cells and island-cells. Remarkable vacuolar degeneration of parenchymatous cells and island-cells. Arophia and dissociation of parenchymatous ‘cells. Hemorrahges in acinous cells. VLiffuse hemorr- hagia per dlapeaisin in interstitial tissues. i... 415. 4n autolysis, Hyalinous degeneration of blooa-vessel-walls. “ Remarkable cloudy swelling of parenchymatous cells and island-=cells. Vacuolar aegeneration of islana-cells. Remarkable edema of interstitial tissues... Dissociation of parenchymatous cells. (B) SUMMARY. . stological observation on 26 microeslices, I case with severe post mortal changes, i}. Acitnus, I) In the most ceases, with some congestion of inter- and intra~acinous capillaries, . Congestion in sl ight degree. & cases, Congestion in medium degree. “12 cases. Congestion in severe degree, 4 cases, Congestion with hyalinous swelling or degeneration of capillary -walls, 47 cases, ; Congestion, accompanied with considerable peri~ vascular hemerrhages, ll cases, Gongestion, accompanied with some perivascular round cell -accummlations (some leucocytes, lymphocytes, plasma-cells and histiocytes ) ' 43 cases. Accordingly the main pathological changes are following: Congestion (often, remarkable) ____—- Edematous swelling of capillary walls ss Perivascular edema, hemorrhages end some round=cell-accumula- tions (sometimes leucocytes disseminations in interstitial tissues). :., 2) After that, occured some degenerative changes ©. of parenchymatous cells esp. at pericapillar pore a With cloudy swelling of parenchyn celle in slight degree, I! cases, in medium degree, “25 case, in severe degree, 0 cases, with hyalinous degeneration. O ease,. With hyaline -droplets formation, ‘0 case, Accordingly, it shows generally some considerable parenchymatous degeneration and sometimes, some remarkable changes without hyelinous degeneration | or hyaline-droplets formation in acinus, B). Islands, I} Sometimes, with considerable congestion of islands-cspillaries, Congestion in considerable degree, - 2 cases. aS Congestion in remarkable degree, accompanied with edematous swelling of i ee a I “ease, Congestion with our sorcalled "polar odena", QO case. a. © Congestion with our so-called “serous apop= ae lexy. of island", | : O case, Congestion With our somcalled (hemorrhagic) apeplexy of islands, : : ' ?. case, 2.. Sometimes, some degenerative changes of island- cells, : ; With rether atrophic cells, . = case, With cloudy swelling, 24 cases, . With (alight) vacuolar degeneration, T6 cases, PANCREAS 99/001 suoluslarloaly Fad EATATANACACATACAEATA i— [—|—[=] =| + [+ [+ [+e [ae [+ | + | — | [+ [+ [=] =| \— | ca Gc a EE ame S| a easy | I= | I= i= | ee [BE I+] i— | Hn |N [te LHe EES i= | I] 21 | I=] =| = = 4 LeuGOCYTES 5 : q =, fanules” a senéeranon : -! | [. Karyolyns... oacinar Cas eigeerlcrenfOue iS Edemg ryTnrocytes Hyperplasiaace ~paacteit AymMosen SL bystecianron Changes }-—= Nuclei = © eWALDUDIEd IY? SnUoy IS usioluy pues SSUELEBUET N =normal or the slightest Decrease kay PY) oom Parenchymatous deg generation, : ae. £ 3 accompanied with some cierhotte ao Aah V3 ; Yds See o intersttial tissues. Increase of fatt.y tissues ( not so significant changes ). RPS” g degeneration, Parenchymatous degeneration. mM Gof X73 — Vacuolar degeneration of “* Hyaline aroplets degeneration of island. Moet xp fo intense cloudyn degeneration of island. F P Apoplexy of island. enorrhages in island. Edematous swelling at PY Yo x 2>0 Edematous swelling at our so-called polar portion of) island, in a teD power, Tatese sengestion and gous ) whages in island (sesel. Up Edenra Degeneration Necrogis. Congestion # . Pericapsular J Blood Vessels _Proliterarion ry * Fibronistiooytic Cells . was Hemarrhages ‘, We! Formation # @ tyaline-dropters. > .. Leucocyte-accumufation Dd TiOn ...}- bot _ NacuotarDegeneratian Muscié-bundies Hy D Sr Medulla®” Celts "Roun Cell Infiltration stnick i Capsule ---- Z Hypertrophic” Senin : Cortical Cells. Guenaier ies #Bacterium aioe ea Honeycombed ¢ ' : ee Fical Begeherarion Giant Cell Cetls , ee () SUPRA-RENAL GLAND, 2. | ee (A) Microscopical Investigation, I7. ; Considerable atrophia, degeneration and ; dissociation of parenchymatous cells, esp . in Z, reticularis which are in ruining _ process, Many polynuclear leucocytes (containing mye = locytes) in capillaries of Z. reticularis, Small round-cell-infiltration in Zs reti- cularis (around the central veins), - Some medullar cells with large nuclei and karyokineais, 54, . Considerable congestion and slight: partial 7 hemorrhages in d@psule. Cortical cells in more or less vacuolar degenration, Z, faciculata with some cell groups in honey~ . : combed degeneration and Z. reticularia in ruining process. ; ae _Gonsiderable edema end partial or diffuse hemorrhages mainly in Z. reticualris, . a 93, 225, Considerable congestion in subcapsular capillaries and diffuse hemorrhages in 2. reticularis, Z. fasciculata with some cell-groups in hypertrophie and in ademous cell-arrangements, ; Some medullar cells with large-nuclei (I7p in dimeter as longest) and karyokinesis, Partial hemorrhages in capsule, Considerable atrophia and dissociation of parenchymatous cells, Z. reticularis in ruining process and in diffuse hemorrhages, ; Some meduller cells with large nuclei, 320, : Cortical cells in consideravle dissociation, more or less considerable atrophia and vacuolar degeneration, Considerable edematous swelling of capillary-walls ang taultiple hemorrhagic Places in Ze reticularis, which fall into necrobiosis (karyorhexis and disappearance of nuclei, etc) in adjacent parts. Considerable smell round-cell-infiltragion in Z. reticu« laris (around the’ central veins), 325, - _ Remarkable vacuolar degeneration of cortical cells, Cortical cells in 2 types: a) with , bright and more or less swollen protoplas- ma and bright nuclei and b>) with eosinop- hilic and more or less smaller protoplasma and chromatin-rich or frequently phycnatie nuclei, ' ; Bactorlal masses in capillaries of 2. fas- ciculata, Considerable edema and diffuse hemorrhages in Z. reticularis, Small roud-cell infiltration in Z. reticularis (around the central veins), 328, Pabtial hemorrhages in Capsule and consider« able congestion in subcapsuler Lisavecs, . Cortical cells in 2 typee, as above mentioned and Z. fasciculata in more or less adenoug cell-arrangements, Medullar cell; with more or less remarkable vacuolar degeneration, 388, ee aad Some cortical cells with honeycombed degenera= tion in Z. fasciculata, Some cell-groups with hypertrophic cells in Z 2IS ty ‘ Considerable congestion in subcapsular capillar-—nets and remarkable partial hemorrhages in Z, fasciculata and 2. reti- cularis, : Some medullar cells with large nuclei and more or less degenerative protoplasma, 388, Considerable atrophia and deaolative decays of parenchymatous cells (cortical cells in remarkable vacuolar degeneration or in partial binnecrosis), Considerable edema and diffuse hemorrhages in Z. reticularis, ; More or less remarkable vacuolar degeneration of meduller cells, 590, : Thick capsule with slight hyperplasia of Z, glomerulosa and multiple miliary abcesses in cortical tissues with total necrosis of Ze fasciculata and Z, reticularis, pares: At some places, slight hyperplasia of inter= stitial connective tissues with giant-cell (Langhans ts type)-formation, Some medullar cells with large nuclei, Bay os dotaetnA WU eA Oa atith ia: swelling of medullar tissues, F E . AIF eked Edematous swelling and degenerative decays of the walls (mainly smooth-muscle) of central veins, 393, , ; Degeneration and desolative decays of parenchymatous eells in severe degree, esp. in Z, fasciculata with partial bione- | crosia, Slight hyperplasia of Z, slomemiles: ga, . — noe Honeycombed or vacuolar degeneration of nedus liar cella, Remarkable edematous swelling and degeneration of the walls of central veins, 396, _ Sac Dee etl Remarkable atrophia and desolative degenera- tion of parenchymatous cells, esp, in Ze fasciculata with partial necrosis, 597. 4 . ee Vacuolar or honeycombed degeneration, esp. in 2, fasciculata, => ’ ot ; More or less remarkable edema, Bacterial masses in capillar-neta and slight peri- vascular leucocytes infiltration, | More or less considerable diffuse hemorrages in Z,.— reticularis, —_ Some meduller cells with large nuclei and 399, a ; Considerable vacuolar or honeycombed degeneration of parenchymatous cells (aca- ttered in reticular tissues) with remarkable. hemorrhages in 2, reticularis, 400, Considerable vacuolar or honeycombed dege- neration, More or less intense edema with diffuse hemorrhages in Ze reticularia, 405. oo Vacuolar or honeycombed degeneration of parenchymatous cells, esp. | 7 a in Z, fasciculata, With diffuse hemorrhages: in Z, reticularis, ; Some medullar cells with large nuclei; 407, . . ae Honeycombed degeneration of parenchymatous colle, asp, in Z, fasctoulata with aubwili = ary abscesa-like changes (lecalised henorr=, hagic parts and prifocal leucocyties accumnu- lation), - 429, a ne Considerable atrophia and desola tive dege- neration of parenchymatous cells, More or less remarkable edema, Considerable sub- ges in Z, reticularis, Bacterial] masses 410, aa : Considerable atrophia, dissociation and vacuolar degeneration, esp. partial necro= sia in Z, reticulsris, Plenty of Leucooy = tea (containing myelocytes) in capiller= nets of Z reticularis (these are more or ‘less degenerative), — . Some medullar cells with large nuclei and karyokinesis, ; Bacterial masses in the central veine, 41I, Oe Considerable vacuolar degeneration with more or less remarkable edema, Medium subcapsular congestion and intense diffuse hemorrhages in Z, reticualris, . ‘ Considerable vacuolar degeneration of medte liar cells, 416, . fyg8@ 9% on OD Considerable vacuolar degmeration and edema, Intense diffuse hemorrhages in 2. reticue laris, ee... 417, “Partial hemorrhages in Z. reticularis. Kemarkable atrophia, intense desolative decays cr vacuolar degeneration of cortical cells (cortical cells are ruining). Intense edema and intense diffuse hemorrhages in Z, reticularis. Small rouwnd-cell-infiltration: - in 2, fasctculata and reticularis, Sonsiderablo edema of medullar tissues, 401. (post entry) Vacuolar or honeyconbed cegeneration of parenchynatous cells with diffuse hemorrhages in Z. reticularis, . (3B) SUMMARY, 7 , Histological observation oh 22 micpo-slices, a) Pericapsular tissues: Intense congestion in ro cases, Hemorrhage in I7 cases, 7 of them in more or less severe degree, . Remarkable desquamation of endothelial cells of capillaries, in 3 cases, Generally slight perivascular lymphocytic or leucocytic cell infiltration, bd) Capsulsr tissues: Edmatous swelling in IIT cases, 7 of them in severe degree, Remarkable hemorrhage in 4 cases, Congentially think capsule in 5 cases and localised cortical cellgroups in capsule in 5 cases. ; ¢) Parenchymatous cells of cortex: I) Z.- glomeruosa, ; Atrophia in 8 cases, ee Slight hyperplasia in 2 cases, Iof them with compensatory hyperplasia, due to total necrosis of Z, reticulalis and Z, fascicu- lata, | _ a Glomerular cells with large nuclet or karyo= kinesia in 4 cases, . 2) Z. fasciculata, : 7 Generally in all cases, cortical cells are in more or less degenerative with verious and intense nuclear changes (pycnosis, karyolysis and karydrhexis). In the most cases, more or less decrease of fatty contents in protoplasma (splitting of fatty drops and protoplasma with derk end homogenous tone. Some cases have localised seate of residual fatty masses), Vacuolar degeneration (according to Dietrich- 's concept), in I5 cases, I of them in a severe degree, Honeycombed degeneration (according to Dietrich), in IO cases. 7 Formation of adenous lumina in fascicular cords, in I7 cases, I5 of thom slightly — and 2 of them in severe degree with decayed masses of Cesquamated cortical cells and some erythrocytes in lumina, Soe ee luce Remarkable atrophia of fascicular cells, in 13 cases, — ~ € 23 oh 8 cases with hypertrophic cortical cell= groups. ord | Dissociation of cell “arrangements in 13 cases, 9 of them in severe degree, Ta |: Parenohymatous disturbances with intense ruining changes, in @ cases, 4 of them with sme localised partial necrosis and I of them with diffuse intense necrosis, (multiple miliary abcesses fused each other), in 2, fasciculata and Z, glemerulosa, Their glomerular cells are in eompensaby hypertrophia, as above mentioned, Accordingly in this disease, parenchymatous disturbances of cortical cells are more or less intense. Note: In some case, cortical tisses are tn confusion of 2 typed cellular attagements: a) with bright protoplasma und bright or swollen nuclei and »b) with eosinophilic protoplasma and chromatinrich or pycnotic — nuclei, a) Interstice of cortex: Generally with remarkable edema, I2 of them in a severe degree, ; Frequently with remarkable congestion in capillar-nets of Z, reticularis and sube capsular tissues, Generally with more or less conusideredle leucocytes as capillerfcontents, In 8 cases o arkable and in 2 cases - of them, containing myclocytes, More or less remarkable localised small rounc-cell-infiltration (generally in 2. reticularis, around the central veins) in © cases, In the other cases, more slightly or scarcely. Wi th some hemorrhages in 21 causes (37 cases of them in a severe degree), Generally in Zz. reticuleris partial or diffuse hemorrhages, and occasionally in Z, fasciculate partial hemorrhages. We advocate the concept” Epinephritis serosa", refered to Hepatitia serosa as Eppinger's meaning and classify cortical changes of this disease as followed: Epinephritis serosa I degree, | in I3 cases : Epinephritis serosa II degree, . in 7 cases, ; . We can find in so many cases (16 cases), _ leucocytes~infiltration in cortical tissues and in 2 cases miliary abscess-like changes, ’ These facts are unusual in the other diseases, e) Medulla: Generally with edematous swolling, esp. 7 cases of them in a severe degree. In all cases with more or loess rewarxable vacuolar cegeneration and in 4 cases wit *rcline -droplets*formation. Medullar cells with anisonucleL in 7 cases and some of them with karvokinesis, These facts signify the initial silica of medullar wroerteophia, Gensvally vith slight Lemeorrhages and small round -cell -infilirgfion in medullar tissues | and 2 of them with intense cdematous swelling of smooth-muscle-bundles of the central-vein~ walls, Ganglion cells in all cases, with more or less tygrolysis, karyolysis or vacuolar degeneration of protoplasma, 9057 SUPRARENAL 7 3 ae Lit ie el ee opener fea] L_. Scrous Inflammation “TTT T= TTI [TIT iT [ i PERRESPSER SE ah: is ae j— [+ Ht [4p [a ee EEE eee [= f— J f= | a Eee EEE - HER EE ico cod Race Roel Ree Rael ca Ko Gage Gok cl : [Elle Tele ee ETE ois es a ea ad EE SSeS ES eee cee ee es p= 1+ [4 [= [4 | \— — E= F EE E- = [= [= [4] I= [= Re Eee ae. Se eee ee P| ae [4 [4 [=] [Te 4 at a eT cae ee : CE BS SS ed Ed oe = {+ [—|~ |—|= 4 ]—|=|—)— |= | | - - ee Eee. pea ea Lae “tt [at [ie [ae [ae [8 Fe ee Te Te j— | [| [+ [= a EEE ae: — fh | [=| — = [Tt [= T= a aE -TSR: Fbinia Lumina {= [+(e l= (ere ee -e E Ee EE e S| Chen erosie at eee ee EEE [+ | [—[~[+ [els et [Tee [EE] te {te [| [4 = Te eee EF ST + |e [=| [4 | We | He [ae te — = | 4 He |e + = | i+ f—f—[+ |= [= [=] 1+ | | Edemay ee = ae el [+ [4 eS aS ; tHe |e [| [+ [|= | [+= TF] [oe [= [fae fey ite |= [J [=] [= [+ TF = ee ae] +} He FS EELEE PEER EEEE : |= | ed eed od oe De dd de ee sie SE ee ee My ald Dd dS ed ed bd dP a eC ee eco i |= fel ee edd as at a Ed f, HyBerplasiaet Capi el Ge eel el eel Ed Kal el el Gel eel Devel eed keel eel es oa Oa ad Den |Porenchyma [EE rr drops [tI (= = SI ee eee gg etetsted reteetel et et eer ttt demia’ [> TS = SE eee “44 f ,__ Congestion EIR Se ees ee ip Cidinsoibal bone =| Sts Hae pe ee ‘[urcumscribed Round celiinfiiration — [= T= [STV eT EET PET ENT TEE Erie Leucocytes~accumulation in cortical tissues, accompanied with intense ~° bionecrotic changes of parenchymatous °: cells. aa cf - 407 x109 Intense bionecrotic changes of ees : cortical cells. Pane 3%0 Saree ED Vacuolar degenanation(Dietrich) of cortival cells. : { Honeycombed ‘degenerqtion( Dietrich) of cortical cells. . vie ak. ook Hypertrophic cortical cell group. Degenerated cortical cells in 2 typesia)bright and more or less swollen protopl,sma withbright nuclei b) eosinophilic and more or less smaller protoplasma with chrdmatinerich "4 3?5 x Poo or pycnotic nuclels late accompanied with intense degene- pation of parenchymatous eells. festtoulass Tntenac tpted nesrande of 3, “ é. Giant cells in cortical tissues. 3490 KE GOD 7 CORE... ch quantity Z colloid(ieye he of Colloid ee Papillar formation. Ma 7 7 ee ; tibrosis vasophi Ite , Ai tolloid i “Cylindrical epithelium - Flatte ” distiquyi yetee t-~ Pillow. formation | Sat i PRG} Parafelliculay cell 4} --desquamated cel t,o ag ‘ Y.... vacuoles ad the may in of “acest se fallicleg Hluiditicatien ~edama f colloid}: / an as © focus of lymphooytes’infilt, Focus of heenorhage bacterial collony Wa (COMMING xk ford (A) Microscépical Investigations. @ 17. Struma colleides nodesa levis. Slight activated state of thyreoid-tissues with slight hyperaemia, pillow-like or papillar inorease of epithei- ial celle and some parafollicular celle. Vacuole- formation in colloidal masses at the margin of fol~ licles. \53. Slight fibrosis. Woondensation of colloidal masses and a slight dege- neration of follicular epithel cells, and some para- follicular cells. , 54. Struma colloides diffusa levis. —_ Slight hyperaemia and pillowvlike or papillar increase of folliculer epitheliel cells with sone microfollicies- formations. light hyaline degeneration of arteriole- walle, : ‘245. Struma colleides diffusa levis Slight heperaemia end pillow-like o of follicular epithelia 8 with some microfelli- eles-fornstions, 3 ht hyaline degonerstion Cles-format - Slight hyaline degeneration of @riolo~walls, ilar increase “225, Struma collcides diffusa levis. ata oy ef epithelial cells with some desquamatad epithelial \\. *light hyperaemie and pillow-like or papillar inéréase:. , 3 - cella in follicles. 518. Acute Gisfiguring of thyrgoid in medium degree. Considerable congestion and ddgenerative processes of folliculer epithelial cells (flattening, cloudy swelling, pycnotic degeneration sy : of epithel cells). Slight incre vasephilic colloidel masses and at some places eon-, Sipe aELOT 8° OEE Cee DOPIONSEES ravens LLURELL keaton: o siderable collapse of follicles (severe fluidification of colloidal masse) with increase of colloidal masses in perifollicular connective tissues. At some places slight hyperplasie of epithelial celis. #0 as to form pillow-like orpapillar arrangements -with many microfollicles. ; 520, Strum colleides non-proliferativa. /Thyreoids in statical state with flattening of epithal cells. At some places slight desquamation or desolation of epithelial celis and at other pleces, slight hy- _ perplasia of epithel cells. 328, Thyreoids inbtetical state with slight desquamation er desolation of follicular epithelial celis, 389. Acute disfiguring of thyreoids dn medium degree. . Camsiderable ‘ ‘ ; , 2 j Congestion end degenerative processes of follicular epithelial cells (flettening, cloudy ‘Swelling, byonosis, desquamation and desolation of epithelial cells). ar, ~ 593. Acute Spee: in medium degree... ' Considerable congestion and degenerative processes | - \ of follicular epithelial calls (flattening, cloudy a swelling, pycndsis, desquamation and aome desolation of épltbelecells) with increased basophilic colloid- al masses and cellapse of follicles (rlutergized colloidal masses), Without any proliforative changes, Colloidal masses inilymph-vessel and slight edematous swelling of peri-follicular connective tissues. 596. Acute disfiguring of thyreoid im severe. degree. Considerable congestion, more or less swelling of blood+vessel walls and alight edematous awelling of perivascular tissues. Follicles in various forms: some macro-and some microfollicles, with some degenerative processes of follicular epithelial cella (flattening, pycnosis, remarkable desquamation and desolation of epithel- fal cells). Increase ef basophilic colloidal masses and sellapse of follicles in severe Gogree. Colloid- al masses in lymph-vezsels. oe Bacterial masses in follicies without any prolifers- $X¢e changes. 399. Acute Giafiguring of thyroids in slight degres.. Considerable congestion and slight edema in perivas- cular tissues.w. Sone degenerative processes of fel- iculer epithelial cells in alight Gegree and slight a ... increase of colloidal masses in follicles and lymph- vessels. . : At some places, with yee hy ; ot follicular es ' 402, Struma perenchpmktosslavtis,, on from goneidex ais follicular collapse. - Slight fibrosis and hyaline Segenerohicn of perifol- licular connective tissues. 40S. Acute dasfiguring in severe degree. 7 - Considerable congestion end edematous swelling of in- a. terstitial tissues with some degenerative processes | T) My) of epithelial cells (esp. desquametion and’ desolation) 44n high deggee, a . aie f} Increase of more or less basophilic. colloidal masses and fluidification of colloidal masses with their accumulations in lymph-vessels. Follicular collapse dn severe degrec, 408. Thyroids in statical state with slight hyper- plasia of follicular epithelial cells. 406. Thyroids in activated state in slight degree, Considerable. congestion and hyperplasia of follicular epithelial celle so as to form. pillow-lite or papil- - ler eprangement and at some plices solid coll groups. | . with some parefollicular cells. eon. : 407. Acute disfiguring of thyroid in slignt cegree, Condiderable congestion and follicular collapse in — le 40 —_ slight degree. Degeneration and desolation of epithel- nh dal oella and slight dal maases in follicl collapaé with eome degenerative processes. At acme on Places slight hyperplasia of folliculer epithelial == cells to form pillow-like er papaillar arrangements, . 410. Aoute disfiguring of thyroid in demtum degree. Remarkable congestion and perifacular hemorrhages and swelling with remarkable degenerative processes of follicular epithelial cells (cloudy swelling, flateen- ing, desuqamation and desolation of epithel cells) and comsiderable fellicular collapse. at some places, peraigtence of lymphonodular tissues — with remarkable congestion and some hemorrhages in | lymphonoduli, ee 415. Acute disfiguring of thyroid end slight 3 agen nerative processes. Considerable congestion and sone perivascular: edemat- ous swelling with Gegenerative processes of folltculer | epithel cells (flattening, ‘Cloudy. avelling, pycnosis and Gesquamation of epithelial cells). Increase of basophilic or fluidified cohloid in follicles and . lymph-vessels: follicular collapse, Beside these degenerative changes, alight hyperplasia , of epithelial cells to form eae patch acai Es. .,, 417. Aoute disfigi Dye Considerable. congestion ahd yo. re hemorrhages and edepatous swelling, accompanied with | wevere degenerative processes of follicular epithelial celle (rensrkable degeneration, desquamation end desolation of epithelial cells) and follicular cellapse. Without any preliferative changes and increase of colloidal uasses. some bacteriel masses in. bloodevessels. 26. Acute disfiguring of thyroid. . | ' C@ngestien and slight fibrosis with some degenerative SS \ anges ef follicular epithelial cells (deaquamstien i ( and desolation) to fall inte more or less collepse- (=) ag state of thyroid, =) Tucrease ofcolloidel masses 1nffollicles end lymph- 4 vessels. , a aan (B) SUMMARY 1) The bird-eye-views. of patholigical changes in all cases.. Changes, due te infection. Ground-disense. 17 = slight activated state Struma collbides nedosa. 26 acute. disfiguring in slight degree. 55 gtatiealestate Ligh ee da fase (rather degenerative) er teeee ae mire : form 54. slight activated state. atrwma colloides some microfolli- diffusa levis. cles. 225 slight activated state. - struma colloides diffusa levia. S18 acute disfiguring in medium degree. S80 staticalsstate atruma dolloides non~-proliferative. 528 acute disfiguring in demium degree 393 acute disfiguring in medium degree. Ra 319 396 acute disfiguring in : ome bacterial fe alta ie Basses in follicles. - 399 acute disfiguring is slight degree. X 401 statioal (rather | Struma parenchymatosa degenerative) state levis. foliieular cellapse. 403 acute disfiguring in severe degree. 405 statical state. aren F a fr EEADnGpeSPsbhsacsesseietigeeanaassnaeinane, : 406 activated state a gaa sai 407 acute disfi in sitpn guring t degree. oY RS ns, ' 41D esate deafiguring ia : eraiatonce of 2yapba- prada as Daa slight hemershases. : age dia w 415 acute disfiguring in ae gee slight degree, 417 acute disfiguring in : somebacterial masses. Gemium degree, . in “eap Liarties, : ; All microscopically investigated cases in 19 cases. with acute disfiguring of follicles. im II cases. in slight degree, . in 4 oases. in medium degree, in 5 eases. in severe degree. in 2 cases. with activated state, in 4 cases. A : - with non-activated, statical state. in 4 cases, with remarkable bacterial accum- . f dations.in follicles. — Accordingly, the: most Gases of them fall inte acute disfiguring or . somewhst activated state of follicles, due to Anthrax-infectien. Namely after Anthrax-infection, occured at first some activating of - . follioles with considerable congestion and some changes of follicular ~ epithelial cells: : Sometimes in slight activated regerisration, (agit hyperplasie of epithelial cella) ond i sometines 4m slight disturbed degeneration fedent degeneration of |... epthelial cells and furthermore remarkable. degeneration er folli- euler collapse). ; These activated state advanced furthermore inte ‘the acute dtefiguring of follicles with remarkable degeneration of foblioular ephthelial © Cella and some signs of fellicular collapse. As remarkable Gegeneration of eplthelialcdelle: : ; Plattening, clouding, pycnotic degeneration, ipa oraicder! sad de solation of epithelialccelle and as signs of functional disturbances (follicular collapse)§ cast ‘ Increase (of basophilic or fluidified colleidal masses in follicles ‘and dyuphatneide. Accordingly, the developing mechaniams eof thyreoidsal changes, aus . te Anthrax-infeotion are as following: 4 A Bar Statical state. Activated atate. : ; flaw & cases. ; & cases, = an regenerative form. in degenerative form. . 2 cases. state of . an follicular collapse. GQiefiguring. : 21 cases. | 11 cases. : a peonoosn @__karge Foricles ECarsrargcaracacscaracae o\—stran Otlicles ee ee Cysts. FER EEE ree } Nuclei TKaryolysis a -Thexis Bees heel | Quantity pif] PEEL ETETETETED Colloid Hpeereocs fat Eel ed ol od Co Od od cod cod LeWiditication [+ [=|={=[ = ye : Sa 1 SO EES fa 1 Cottotd jn H-vessels ERESGESES I ae Ae Doe tHe Ht +] He Pe t+ “f tetnirte BOUT Sn [=i] cane | =r | |__Microfoificies [+ =i +) C4 |= [= [Ste PR 4 226 1; It. poe = t 318 V ml. + ae t bd) Stroma, Congestion Hemorrhages Roundcell Swelling or Inoreage of ee infiltration Roughness Leydig ® cells ee eg a ee 17- oe +” = as oy 54 + + ae 4 £26 tt > + # N 318 + - 4 } a) Parenohyma. Reduction Atrophis ee of testis ; Tubulus OF Ow Ow ONE SOROS @ OO EOF ESHER O BESET E TOR OOOO SD Saran ae Hypertrophis Giant cell Hyperplasia of formation Hyaline dege- Sertoli's neration of ; cells T. propria, : $20 ~1 I. ~ + 328 06] I, = = + see IT. a = 1 388 =O r. _ = N bd) Strama, Congestion Pemorensees Round cell Suglling or Inorease of dnesteration Roughness Leydig's cells 320 + = zi ae 3a8 + as ae +t ~~ a) Parenochyma, - Reduction +4 — 396 + + ica + + ye Me? ~ = + “ (a) Parenchyma,. Redaction Atrephia of MORI etn Wo beleseds Cen cuanto Tubulus ie Hypertrophia Forastion Byperplesie Rete Hyaline dege- Giant cells serteli's pe neration of i oells ip aes T propria. ; 399 ~I. I es + Le NT 8 4el it. I ms ¥ nN 405 I. af -_— = + 405 L. 1 eae _ aie EE eT ScD re Sr eaesracNSAS b) Stroma. . . , ‘ wi : : ; Congestion Hemorrhages Round cell SWelling or Increase of infiltration Roughness Leydig's cells.. a) Parenchyma, Reduction Atrophia of testis Tubulus Hypertrophia Giant cell Hyperplasia formation, of Hyaline dege- _ Serolits neration of cells T. propria. g 406 1 I, = e i 407 I tL, + = N 409 ~1 L. > = ' 410 I qL. = al H b) Stroma. Pongestion Hemorrhages Round cell Swelling or Inorease of - © infiltration Roughness Leydig's cella, 7 406 as = at, + 407 4 = = ty 4 409 + = => + + 410 a = => it N - a) Perénchyma. J ats: Rediiotion Of. Tubulus ween mew nw ewes enwsenasnsnenmanacecweese woe etonpasenewceneswen ees ae Byperplasia Atrophia teatis Hyaline aege- Qhant cells Sertoli's neration of cells : * .proprés. ; i — az az : : alo: ie 415 =I B: ~ oe N 414 ~1 U. _ + N 416 ~ 0, - - , b) stroma. Congestion Hemorrhages Round cell Swelling Inorease infiltretion or of roughness Leydig's cells Reduction Atrophia of ‘teatis fubulus Rotman me wnw anes enenenenennenemancenemmnmencdnwnnecnene conenoe Hypertrophia “ ormation Hyperplasia or - of of Me i Hyaline dege- Giant cella Sertoli's — re - .' mneration of gells ce * propria. ; a aie; 417 ~1. Testa tca oe ot a cS in b)} Stroma + e 1 ’ — . ea ah : vopeeation Hemorrhages Hound cell Swelling or Tnorease ot B) SUMMARY (I) i oe Our classification of "disturbance of spermatopotetic process". a) on the “Atrophia testis". ee & ye ee Atrophia testis 1.. Atrophia testis 11. Atrophia testis 111. Atrophia testis 1V. ‘Atrophia testis ‘, b) on the reduction 9 tubuli seninifert. ‘Reduction 1. Reduction 11. Xeduction 111. Pyknotic spermatozoa. ; a Relative increase of _prespermatids end : spermatids. Degeneration of sceanuincne and - eperme-" tids with somewhat considerable excoria- 7 : tion of somewhat giant. cell-formation (as signs of degeneration). Remarkable degeneration of preapernatide : and spermatids. ee Remarkable degeneration or acuet ines com. plete diminishuent of spermatocytes, ; 2 . : Degeneration snd. sometimes, irregular oelt- 3 arrangment o spermatogonien. Vomplete diminishment of spermatic colle. o Remarkable swelling and hyaline degene-. ration of ? propria of tubul seniniferi. Diameter of tubulus. sentniferus as reat at to 5/4 of normal.(slight atrophia)< Reduced to 2/4. (medium atrophia). Reduced to 1/4. (severe atrophia). (2) Generally infection causes some disturbances of spermato : poletic process:. Atrophia testis 1. 2 OB canes. zs 11. 18 cases. . lll.” 10 cases. ~-Reduction o& tubuli seminiferi 1, 20 cases. * a0 11. : 3 cases. Sometines accompanied with. giant eell-formation’ of spormatias : and prespermatids, as degenerative signs. a 14 cases. Generally infection ceuses some congestion. Gongestion in slight degree. 14 cages... in medium degree. 7 eueee ; in severe degree. 4 cases. Sometimes hemorrhages end edema in interstitial tissues. Hemorrhages in slight degree. 18 cases. in mediun degree. 2 cases. Sema ' . 4n medium degree, 18 cases, in severe degree. 4 cases. o Accompanied with sometines some round cell-infiitration. in slight SOeEee 24 cases. Leydig's cells. Sometines increase. a8 : tn slight degree 22 cases. . . in medium degree. 4 cases. Sometimes decrease, in slight degree. 5 cases, — in normal stat TESTIS aco +t oo a +f] ty c istratapt “ProprialFiprous begéneranon | + [+] | I+ [= [| valine Degeneranion gaia [—|—| D Pel Pet i g pa TEU Peet Pd eT eY ey ee fee[fe T] F HH o c rr Zz il LUPE e+] Pee ere + ef ta] fe Ea | |= | N= | | =I PEELED pe EEE Eee =T—] Quantity [ile neh Deseneranon Pita guaniiy | te ig IS i matios f beseneration| + [+ [+ [=| | POuantity Kee EEaen pescreraton| a LL ELA I Es | rel Fe rs Pee EFE) FE] HE ie Fr LH ee PR Ft fe] fet [ey BOGoo we TISSUE Seen H MENT ir [Hyaline Degeneration [Swelling L quantity onigestion Hemorrnage Round el Infiltration | If elincresse connective i Li Grade + Atrophy | “LU Pep el far Fe ORG EE Boks offerte a tre peer Perera ett | Co $ SOG DOGG G GIRS Meo PUT EET FL eee ad et eae pep HT er eT Glia Gea wo cd co cack 2 OCOD OCR Coote i{i DCO On [Grades -Reducnon fe f+ Pee ee Thickening + te EEE eae ; [Propria Fbreusbesenes on permaredonien. permatocytes p= =m pesca teeter ree Prespermatiés | Oyama Fe EP EES ie eee Spermatids Quanity fe De ae eae ca eaee ane Ht | + | 4 | +] Go Gel oet eels L-Quannty hie PEE he acme Ere ts Ii Se aon ba a ae eee ees EASES enor ase ee ROU Mriltration.. SSeS micreases orn CHVE TISSLE [= [J — J — ye} Deseneration«Pndoielium | + | || [= [1 | ie i Maine Degereranon He tart=fet Taaysmad. Quan —— pat | foe [oe Pe [ae eT] : Se ae ed Oe Cree Cel eel Round cell Infittator Ee ee Se Faced Ee ad ens Ed S DESETICTa Alea Gath fies =|INCTEASE # CONnECTVE TISSUE! ad _N=normat Atrophia testis III. Atrophia testis III zand edematous swelling of interst£itial tissues. ae ‘ Atrophia testie III, accompanied with | Sea, | diminish of spermatozoic cells. Atrophia testie III, accompanied with Slant cells formation of apermatogonic cells, as. ~~ , “LR car gists . PITUITARY -B0D%,. (A), Microscop, Investigats ae we , Partial hemorrhages in ogpeutes | Severs co ngestion in anterior and posterior lobe (with some leucocytes in capillaries) and edema, ‘Slight parenchrmatous, degeneration, Slight partlal hemorrhages, severe congestion and gubendotheliar edema in. anterior lobe, Slight parenchymatous degeneration, 7 _Bore or less atropuaic and dogenerative glandular. cells with slight : dissociation of cellular arrangements, Some bacterial masses in on capillaries, Slight congestion ané@ flat, men cecutts endothelial Pe In’ posterlor lobe, som3 ¢apilleries include leucocytes. +64, . . : 7 4 More or less atrophic and a gcusrabive glandular cells epkse slight dissociation of ool tulaty’ arrangements, Non active endothelial settee 408. 2.) . Bes Almost normal with slight proliferative tendency of basal meubrane. wandering of basophilic glandular cells in pistenion lobe, 409, . Slight congestion. and slight parenchymatous degeneration, No remarkable changes else. 4T0. - ae : 7 i bsae -. Mere or less considerable congestion an oF and degenerative glenduler aells, Slisht nertvassular rouni-sall eaccumlation in intermedtete lobe. Att Intense aonsoshton, een ent newt i eT Heiorr ase s in antertor Labe, wore or lesg atrowie and degenerative slewular salts, (aan. th hemorr asta nantes), XN é ra (8B) SUMMARY A.) Anterior lobe, EN I) Always with somewhat capilisr congestion. Gongestion i slight degree. 2 cases. . an medium degree. es ft onses, 7 . dn severe degree. . 3 cases, . n_-Seyere—degres, | ne, eee Congestion with some leucocytes, as capillar contents, j cases, Congestion with some vaéterial masses, as cap~contents, 1 cases. Congestion, accompanied with perivascular hemorrhages. 3 cases. 2) ‘(After that, occured some signe of so-called serous inflammation. S-I, With considera>2c suvendotheliar edematous swelling, — { cases, SI, accompanied with some dissociation of cellular arrangements, 2 cases, : SI, accompanied With x :se degenera ave changss of capillar endothlial. cells (Swelling, clouding and desquanation), { cases, We classificd these changes according to the concept "serous inflem- mation", which we prefered, Pitulteritis scrosa I Segrect 4 cases, II Gegree, + | 1 casos, . III degree, : rae, | cases, 3) Then, it shows. some Cege nerative changes of parenchyiwatous cells (esp, basopuitic cells), esp. ab perivascular porvions, Cloudy svelzing in slight iegré6e 2 causes, ee Cloudy swelling in on 3 cases, _ Gloudy swelling whth vacuolar degenorations, 4 cases. B.) Postertor lobe. Somotimes, with considerable corgesticn ana following changes, Considerable congestion, , 1. cases... Consiégreble with slight pcrivescular ienorrhages. { cases. Considerable with slight hyperplasie of nevroglia cells.ocases. Accorcingly, the significant ain’ patholosica changes are slight Pitultaritis serosa (congestion, serous exuzetion and sone parenchy- matous degenerations), PITUITARY. BODY pe a[Ss«demorthas = HASH Infiltration + Round ces |—|[—|—-l=1—t=|[ =) ‘pe Congestion we = Te [=F a] ———Henotnege —— eee -rnniiraton 9 Roore vets t= |= |= t= t= Dare chiataus Degeneration ae acl eS Bt Pyknosis J |= (-[-- [Ef [=] : -—Karormers T= SS SSS | __—dKaryolysi§ f= }— |= |— |= [=F] Pare besenera ee LATrophia = TTT Ie] pa PU RNOS IS 2p ee ale i [= [=] ——Feermens eS |= |= |=] Karyolysig = |= T= [= = TS] pars Desonemror == Feta fs et | Atropnia SSS ———Wienesis— Se {| Sone fat ttt te E— Necrosis ———.J= SEES t——consestion EA Ee | Edema eG Te iG hammer Rees core TEES Hrifiliration o Round cells [— [f+ [—]—[- [= [-] F mmntiomormase—f=l= [— |~ {-{—|—[=]=] [+ [—[— [=] . Met olor Fearon d (MIR R TR + [+ |=] Homorrhages la adeno-pituitary t 2 : | body. Hemorrhages in pltuitery body { anterior lobe) Bacterlal ingasse¢s and perivascular degeneration, Leucoesrvtess in capillsrics and porivas¢ular ‘edeva,in anterlor lobe. foes OWE ‘ a) Microscopical Investigation. BA, Phieguone Gizrabe, - Diffuse phlegnons tn ‘gubouteneous q ine severe degree) and catansous tiasues ‘eitn intense leudocytes “(and sone ‘Lympbiooyten) “ “infiltration, accompanied with severe se- ~ rous exudation and intense diffuse hene-. rrhages (so-called plood~sea). Capillaries in subeutansous tissues with oy plentiful Leucceytes necrotic ruin of ca pillery ~walle ,interse perivascular edema and hesorrhages, intense Leuscoytes -enig- ration (hematogenous metastatic charactors bret invading phlegnoneously ell éver the neign= ' bourdng tisaues, , . sscompanied with dtrophis .epidermia’ and atrophy or. eollapse of adnex-orgens.. Remarkable congestion of oapilleries ‘at Str. subpapillare vith sone anthrex-deoi12i Accompanied with somewhat necrotic ruins | capdllary-waljs,perivascular edema an. 4 Sige high degree and some localised heworrhages Some perioapillar lymphocytes (and leusaz ‘ oytee )acoumilation and alight collapse Of Bdematous swelling of subepithelial levers of aarti. acings, sespese nisl s: cmt gett BRS Desgcneration of basophilic cslls aa woe ee he oe Ta nite V PCO TCS mae ° @g----- leucocyte oP aN G2 --Longestion a tS __._.elastorrhexis A-.------ Abscess ox phlegmon ms | Cutis x 4 caiinstiie tissue cell: ov histiocyte ~-Bevere degenerad, or necrosis ~--bacterial mass, ' Fatty Ussue.... grees : senna / /. a pe Atrophy or collapse f adnex ovgan x 263 A) Moréaceptont. Inves tigation. . 84, : bouring tissues . “388, ! oytes)acaumulation and slight collapse of ; - ednex-organs. SKIN Phiegmone ‘aiffuse, | ae Diffuse phlegmons in subcutaneous { in severe degree) and cutaneous tissues ith intense leudocytes (and. some Lymphooytes ) iz “infiltration, secompanted with severe s0- ey rous exudation and intense diffuse hemo. 2 rrhages (so-called blood-ses). . Capillaries in subcutaneous tissues with ~ plentiful leucocytes necrotic ruin of ca- pillary-welle,intense perivascular edema and hemorrhages ,intense leuccoytes -emig: ration( hematogenous ~metastatio characters: invading blegmanecnsiy ell over the neigh= Accompanied with atrophic eptdernia. end atrophy or collapse of adnex-organs.. Remarkable congestion of capilleries ab ae Str,subpapillare With sone anthrax -bactilus . Ascompanied with somewhat - necrotio ruins of oapillery-walle, perivascular edema in high degree and some localised hemorrhi e Some pericapiller Lymphocytes (and Leue 409, : Tatense congestion of capillaries: ‘and ; Yoo. - ott hemorrhages. at Str, subpepi2 what diffuse perivascular colluler sastite : ration, (leucocytes, some of ‘them: being _ eosinophilic, lymphocytes and some Ration, 7 - oytes ),Slight fibrosie of adnex-orgens. a - i In epidermis,slight swelling end atrepnlt : . ef piokie oplls and sone parakeratoats ‘above the cutis. B) SUMMARY . ‘Considerable congeation (espectaliy: at Str.subpaptiiare). Emigration of leuccaytes and lymphecytes. “Atrophy of adnex-organs. In' No:54 is diffuses phlegnon : with severe hemorrhages: ‘and fraguentetioi of degenerates epidermis. Hematogencus-metastatic Sharqoter, Ae Gonside: . from peint of neorotic ruins of vessels and Dertvasculer merous axe 8 er infilgration, — M398 Hypermia at Str. papillare. bE mM cy _Hemorrhages and s%me leucocytes —o dissemination in subcutaneous tissues. XY ¢gO 7 Hypesplacia +f qo" tentacw No. va marke bhe changas Hyperplasia « Wf Ratheo Lum all. Conga tive «f Sinus Necrosis Bacterial madds4, LenKe cy tad didsanination Exudution Bienetrvdig Simug Cate Hamomhage a Folljcle Compeation *f Bleed Veaaal. Novmal Sumy Exndotun — ve age LYMPH=NODULUS, (A) Microscop, "Investigation, I7, Mesenterial: - } Lymphadenitis tuberculosa obsolete, with sonaideratle-conpéstion in . medullary sinus, edemstous swelling of ‘capillary walle and slight reduc tion of follicular lymphocytes, 27, Mesenterial: | Extraordinary intense pericapsular hemorrhagic and leucocytic changes — and also extremly severe hemorrhagic = and neccotic changes in follicular tia- | sues with intense diffuse leucocytees = -* emigration, various decayed cellular fragments and diffuse intense hemos © hages in follicular tissues, , 27, Mesenterial: . 23% dime-large, Severest pericapsular — "hemorrhages and leucocytes = omigra~ tion and remarkeble hemorrhagic exuda- tive changes in peripheral sinuses, , Intense diffuee hemorrhages, .necrotic swelling of reticular tissues wi th remarkable leucocytes- emigration in sinuses and remarkable - ~ hemorrghic-exudative processes in some germinative centres, In yet remained other follicular tiss~ ues with remarkable reduction of. - fellicular lymphocytes, and consider a=" ble leucocytes ~emigrations, . 7 Lymphadenitis haemorrhagico-necroti-' cans in severe degree, 27, _Peribronchial: Anthracosis and. considerable congestion (a littie leucocytes as capillary contents) and very Slight reduetion of follicular lymphocytes, . 225, Mesenterial: is ee Slight pericapsular hemorrhages with i slight leucocytes= accumulations, . and Slight catarrh of peripheral sinuses, ; Slight swelling of pulpameshes and slight congestion and slight hyper- plasia of reticulum-cells in madullary sinuses, 325. Mesenterial: Sugar-corn large, Slight paricapsular congestion and nemorrhages end remarkable catarsh’ of. SSF (3)3.) ae peripheral sinuses, | ae Eterm sd wie — a ‘i ‘« % . eon aa. ‘ &s In medullary sinus; severe congestion, necrotic ruins of blood-vessel-walls anc multiple hemorrhages, accompanied with necrotic swelling of medulla ry tissues, In pulpa-meshes: extremly severe hen orr= hages, edematous swelling of reticulum= fibres and remarkable diminution of follicular lymphocytes, ; Lymphadenitis haemorrhagico-necroticans gravis, 3518, Peribronehiel: . Me Svear-corn large, Lymphadenttis cascesa: tuborculosa amt Anthracosis, Slight catarrh of peripheral dinus and considerable hyperplasia of germinative centers with s me increased hitiocytes, accompanied with slight congestion, slight we rivaseuler edema’ gnd alight hyperplasia of reticulum=cells (sone of them in erythrophagocytosis) in medullary tissues, | 320, Peribronchial; Slight catarrh of peripneral sinuses (slight hyperplasia of hi étiocytes) 7 360 . a es peripheral si nuses (considerable hyperplasia end cloudy swelling of histiocytes, remarkable swelling of reticulun-fibres, plenty of leucocytes and some bacterial masses in peripheral sinuses), : In folliculer tissues, at ame places miliary bionecrotic ehanges with some. decayed masses of histlocytic and some bacterial accumulation and at other pulpa-meshes, considerable swelling. : with some leucocytes and slight reduce. tion of follicular lymphocytes, Germinative centres in considerable : hyperplasia with SO mG increased histiocy~ tic cells and some of them fall into 2s cellular fragments and come of them, into submiliary Cassosus masses, Bacterial accumulation in surrounding tissues of germinative centers, : Initial stage of acute lymphadenitis, < iy due to anthrax-infection, . SI8.° Wesenterial; Severe pericapsuler congestion and severe diffuse hemorrhages and seva'e.. bleeding with que leucocytes in St and considerable congestion jn follt-. culer tissues, (aecdmpanted with a2. git» hyperplasia of reticulum-cells. in medu- llary tissues and slight swelling @ pulpa-weshes with considerable reduc= tion of lymphocytes in pulpe-meshos. Lympascentis catarrielis and iuemorr= hagica levis, 7 - 325, Mesenterial; Sugar -corn large, Slight caterrh of peripheral’ sinuses and considerable hyperplasia of reticulum=cells in pulpa-meshes and medullary tissues, Considerable Swelling of ‘pulpa-meshes. and with 9 me leucocytes -emigrations and considerable diminution of follicu-' lar lymphocytes, 380, _Mesenterial: large, = a. Almost normal, very slight caterrh of peripheral sinuses, slight hyperpla- Sia of reticulum-cells in. medullary tissues with slight congestion, No considerable reduétion of follicular lymphocytes, 588, Mesenterial; Sugar-corn large, Slight. Peri capsu ee ucotytes + omige. aie rations and. slight hemorrhages and considerable hemorrhagic necrotic chan= ges in peripheral ‘d nuses feonsiderabie hemorrhages, » more or less ‘remarkable, i leucocytes= and bacterial accumilati ons ye" Considerable - congestion, ‘(plenty bacterial masses in capillaries), necrotic ruins of vesselewalls, severe necrotic swelling * and. considerable. _ hemorrhages in meduld: ary tissues and multiple -subnitliary | hemorrhagicenecrotic portions in folli=” : cular tissues, accompanied with bacterial : accumulations, severe orem tous swelling and remarkable diminution of foliteutan Se epeles ds f, lymphocytes in pulpa=meshes, “ata SS . Lymphadomi tis senor hagicomecrotieans.. 388, Peribronchial: Sugar corn large, The. same hemorrhagic-necrotic changes, 388, Subsextllariss arth te, . Tae. same, hemorrhagic “necrotic, changes 388, ‘pxilleris, ‘Some lymphnodus in large, | : Extraordinary intens pericapsular heme ; a ous swelling and coe 363° ee eae aed I .:- hemorrhagic= necrotic changes in peripheral sinuses. | (plenty leucocytes and some bacterial. * | accumulutions), Severe congestion, necrotic ruins of capillsry walls, severe perivascular. edema and diffuse severe, hemorrhages with some leucocytes -emigrationa in follicular tissues and multiple hemorr= d hagic necrotic changes in pulpa-meshes, accompanied with severe swelling, severe (3 Peery ae leucocytes= emigtations, some bacterial © : ae , eccusmistions and severe diminutionof © follicular lymphocytes. ae es Lymphadenitis haemorrhagieo-neeroti eens, 389, Mesenterial: a Puger Te0eH large. — Slight caterrh of poecpbersl sinuses “and slight hyperplasia of reticulum=, | cells in medullary tissues with consider = able congestion,. a. Slight perivascular edema snd slight hemorrhages in medullary tissues and slight swelling of pulpaemeshes. (with very slight leucocytes ~cmigrations), 395, Peribronchtal: ; “ea catarrh in peripheral. sinisos 1 BES : Bp tee A p~ (389) ial | es OnE EEG, CERN LGR TO 1" ope ap ee tisoues, accompanied wikh slight edematous: swelling and slight localised hemorrhages: in medullary tissues and considerable - swelling with some leucocytes in pulpa- meshes with considerable diminyt ion of follicular lymphocytes, 395, Mesenterial: glight catarrh of peripheral si nuses - Sea v and slight congestion and slight swell= ‘ ing in medullary tissues, ‘393, Mesentertal; Lymphedenitis. tuberculosa, Slight catarrh of peripheral sinuses — and multiple caseous parts in follicus: lar tissues with considerable increased histiocytes walls as perifocal changes (with 08 giant cells), . No congestion in follicular tissues and slight diminution of follicular lympho= | a me 595, Radical mesenterial lymphnodus: Remarkable pericapsular inflammatory | Pid, changes (reriarkable congestion, consider~' able hemorrhages with some bacterial | accumulations) and severe hemorrhagi i 3 rbortipsds ssebtins nea of reticulun-fibres and some bacterial: : masses), Severe congestion (with some bactenshal . masses as capillary contents), necrotic _ ruins of capillary alia, severe necrotic swelling and severe hemorrhagic-exudative changes of medullary tissues, = ee "No significant hyperplasia of reticulum” cells, Multiple hemorrhages in pulpa-meshes, oy accouperied with severe swelling and — some bacterial accumulations in pulpa~ meshes and remarkable diminutions of follicular lymphocytes, Lymphadenitis haemorrhagico-necroticans. gravis, . ae 395. Peribronchial: pease Total hemorrhagio ruins of follicular tissues and severe diffuse pericapsula: hemorrhages, . : 396, Mesenterial: : : CE Almost normal, slight hyperplasia of — an medullary reticulum=cells, No significant congestion, . 597, Mesentorial: yo (396) mentee ‘ ~ Slaght pericapsuler inflamiatory ohanges _ dling and slight hyperplasia of medull=) ( 345) partbr ondhick Ys | aa Sugar-corn large, | (slight congestion, slight leucocytes= emigrations and slight edematous swelling) and remarkable hemorrhagic exudative - changes in peripheral si nuses (remarkable hemorrhages, remarkable exudation. and. - some decayed cellular masses), Considerable congdstion, necrotie ruins; of capillary walls, severe necrotlo: swelling and severe hemorrhagic-exudative . changes in medullary tissues and multiple. hemorshages in pulpaemeshes, accompanted: . wita severe swelling and severe conga ia pulpa-neshes with remarkable Adminuts: of follicular lymphocytes, . eo es 397, _Peribronchial: larga, ; Sligat catarrh in peripheral sinuses and remarkable congestion, slight ewe~. sige ary tissues, No, significant dminution of folliculap’ ' lytiphocytes, 437, “Mesonterial; igat catarrh in veripiueral sinus 467 ani siisas nyperplesia of medullary ©) reticulum-cells, Remarkable congestion, necrotic ruins of cupillary walls and severe necrotic swelling of medullary Lissues, plenty of leucocytes -emigrations and at some places remarkable hemorrhages in follicular tissues, accompanied with — sevore swelling and cons iderable diminu- tion of lymphocytes in pulpa-neshes, Lymphadenitis haemorrhagica, 397, Para“pancreal: le | Extremly severe hemorrhagic esudative | changes in pericapsuler tissueofand severest haemorrhagie exudative changes _ in follicular tissues (severest conges~ necrotic swelling, plenty of leucocytes= anicrstions, considerable hemorrhages and sone bacterial eecumletions in medu- llary tisazues and peripheral sinuses), Severest swelling of yet remained pulpa= meshes and remarkable diminution or diminish of follicular lymphocytes, 599, Mesenterial: _ Almost normal, slight catarrh of periphes, ral sinuses and slignt hyperplasia of: [ned : oe SEs 394 p. At some ee: 4n painidise: slight ° congestion and slight hemorrhages. | No remarkable changes else, . 399, Axillar: - Almost normal, 399. Peribroncnial: : Some lymphnodulus in Sugar-corn large, 4 Extremly severest hemorrhagic exudative » changes in pericapsuler and follicular tissues, Extremly severest congestion, necrotlo ruins of capillary walls, severe nocro- tic swelling of medullary tissues with remarkable leucocytos- emigrations and: severe diffues hemorrhages, Severest swelling, necrotic swelling: — or reticulun-fibres (at some places, - some submiliary necrotic parts) and remarkable diminution of lymphocytes in pulpa-meshes, : : Lymphadentis heemorrhagicosnecrot&cans, 400, Peribronchial:. Some lymphnoduls' in Sugar-corn large, Considerable congestion, edematous (3.91) parilovondial N I”? ‘ agricapsuler tissues and. vemarkeb2 congestion of efferent vesséles . Remarkable hemorrhagice= exudative changes in peripheral sinuses (remarkable conges* tion, severe exudation, plenty of Je ucocy- tes and necrtotic ruins of reticulum= fibres or reticulumscells) and also exe tremly severe hemorrhagicenecrtéic ” . changes in medullary tissues and pulpa~ oe meshes: remarkable @ongestion (with _ : sone leucocytes as capillary contents), necrotic ruins of. capillry walls, severe edematous and heworrahgic processes in wedullary tissues and considerable stio= ling of pulpa-meshes with romarkeble diminution of follicular lymphocytes, 400, Mesenterial: | | Y Very slight peri cepgal ar tnflleamatory: changes and slight catarrh in” peripheral. - sinuses, Considerable congestion | md | edematous swelling -of medullary tiss ves as (with some leucocytes ~emigrations) “and. considerable congestion (at some places bacterial accumulations } | ‘and swelling, , of -pulpa-meshes with considerable diminus: blon of follicular Lymphocytes, 401.. Peribronchial: ae oe a Extrenly severest heriorrhagic“exudative changes of pericapsular tissues; severe diffuse hemorrhages, some leucocyte - omigrations and necrotic swelling of pericapeular tissues, and also extremly severest hemorrhagic exudative changes of follicular tissues: severe congestion, : severe hecrotic swelling of medullary : tissues and pulpa-meshes »* aecowpahied - with severe diminution or ‘diminish of. follicular lymphocytes, : : Lymphadenitis hemorrhagico-necroticans, 401, Mesenterial: came hee Slight pericapsular inflammetory changes: slight congestion and come leuicceytes« emigrations and remarksble hemorrhagic. a - exudative changes of follicular ‘thes uess remarkable Congestion, necrotic swelling of capillary walis and more or less consi@- derable diffuse hemorrhages in medullary i tissues, Slight swelYing of pulpa-mesh ~ ” with some slightly increased, cloudy ae : swollen histlocytes and slight congestion, | Lympheadenitis haemorrhagica, a “40I,° Mesenterial:. C4 3 )peribrmdval ‘Considerable : hemorrhagic exudative meshes, accompanied with remarkable ~ emigrations d diffuse multiple Kai enn ne. a ae changes: in- perieapeular ‘tissues and peripheral sinud: considerable conges= tion, . hemorrhages, exudation md some = leucocytes-emigrations, and intense 7 hemorrhagic-exudative chenges “in folltcu= lar tissues: severe congestion, necrotic. swélling ‘of. capillary walls and moda Lexy: tissues, diffuse intense haemorrhages and plenty leucocytes-emigrations, : Considerable swelling of pulpa-meshes, - ‘with plenty of leucocytes and necrotic. ~! swelling of reticulum-fibres in pulpa-" reduction of follicular lymphocytes.) 403. Peribronchiel; — ae Remarkable congestion, intense diffuse a hemorrhages: aa plenty of leucecyten = emigrations in per veapauier: tissues = and peripheral sinues. a Rowarkable pauorshigle-eauistive changes in follicular tissues: Remarkable congestion, neerotio swelling, of capilbery walls, Recrotic. swelling = of medullary tissues and plenty Leuoeyt {90 matin . : ee er ages (at © me places, multiple submi+ e liary plonecrotic parts). Considerable congestion, edematous. swelling and © me leucocytes -emigration of pulpa- meshes with remarkable reduction of foliloular lymphocytes, : 405, Mesenterial: ” aaa Extremly severe hemorrhagic exudative eee changes of pericapsular tissues and . ‘peripheral sinuses and also the same _ . extremly severest. hemorrhagic necrotic. — (a9 chu changes of follicular tissues: severost ; re - congestion and diffuse severe nenomhages, ‘. accompanied with necrotic swelling of |. nedulleny tissues and remarkable edema= e oe tous ° _ swelling | of pulpa-meshes (with Bien ty Leucocytessemigration and severe _ diminution of folliculer tyuphoaytes), 405. Peribronchial; 3 Seat Sligat pericapsular hemorrhagic changes: . slight Congestion, slight eeeedine end sonie.. leveocytes@omigration and, the Some. hemorrhagic~exudative changes of peri ee . Pheral. sinuses; sligh exudation, some leucoceyte ~ewigration and slight hyper plasia of histiocytes, | emigrations and slight hyperplasia of swollen histiocytes in medullary tissues, and no considerable reduction of pulpa- meshes, 405. Mesenterial: — Very. slight pericapsular inflasoutery changes, slight catarrh of peripheral — sinuses and slight congestion, slight ’ swelling and slight hyperplasie of: ; mecullery tissues. 405. Radical mesenterial: The seme changes. 404, Peribronchial: : Extremly severe pericapsular edematous oak ery ‘slight congestion, a few leucocytes Paty eer amen and exudative changes with slight conges= ; tion, slight bleeding and some leucocyte- emigrations and slight satarrh of peri- pheral ihases (slight exudation, “some leucocytes and slight nyporplasia of 3 t _ swollen histiocytes). ona tos and slight swolling of medullary = oe tissues. Slight swelling and. no other significant changes of pulpa-meshes, 407, ‘ ; ry le pericapsular hemorrhagié. 2 ; — F75 aes Oot eee Very ad ight congestion with a few. r Te we00y~ ah macsaderial (MOD Rake Manges with some leucocytes and ex tremly severe hemorrhagic exudative changes in peripheral sinuses: intemse - exudation, extremly severe: hemorrhages, plenty lezococytes and necrotic swelling | cr secrotis ruins of reticulum-fibres, ‘In medullary tissues: extremly inte se cougestion, necrotic ruins of capillary walls, extremly severe necrotic swelling and remarkable diffuse hemorrhages and in pulpa-mesh: remarkable swelling of reticulun-fibres, diffuse intense hemorr+ hages and exudation, accompanied with || remarkadle diminution of follicular lymphocytes, 407. Radical mesenverial: the same changes, 409, Peribronchial: Extremly severest diffuse hemorrhages | with some leucocytes in pericapsular . tissues and also extremly intense henorr= hagic changes in follicular tissues, the most intense diffuse hemorrhages all over the follicular tissues with : remarkable diminution of all follicular — cellular elements: ronurtable congestion, ' (4on) ant Me necrotic ruins of capillary walls, ee diffuse intense hemorrhages and exudation, -— necrotic swelling or diminish of medullary tissues, remarkable diminution of pulpa- meshes with remarkable swelling; intense. hemorrhage and remarkable reduction of. - folliculur lymphocytes, fo as 409. Axillar: Considerable pericapsular hemorrhages with some leucocytes-emigrations and .- remarkable. hemorrhages: wi th: some. le ucocy- tegemigrations and necrotic swelling of ~~ reticulum-fibres in peripheral sinuses, Remarkable congestion, intense edematous - swelling and diffues hemorrhages in medullary tissues and remarkable edematous or bionecrotic swelling of reticulum= _ fibres, sone loucocytes-emtgration, con= siderable hemorrhages and remarkable diminution of lymphocytes in pulpameshes, 4II. . Perivronchial: . Considerable pericepsular inflammation ce and remarkable hemorrhages in peripheral : sinuses, B97 4, » prribrnclail Se! light swelling and slight reduction of! Pa -meshes Be e/g ye ¢ Mecrotic changes in follicular tissues. a tremly intense total hemorrhagic« with remarkable bionecrotic decay or. diminution of all follicular coll -conpor ot nents, - lymphadenitis haanoreianies gravis, 412, Peribronchia Tue inost Intense airrase hemorrhagic, . changes (diffuse hemorrhages with some deucgeyteremigrations)-4n perigapsular tissues and also the sawe shahges Avemar> Kable heworrhages, considerable exudation, some leucocytes, and necrotic swelling fol s of reticulum-fivres) in peripheralnsinus a ses. Intense acncrrhagic changes in follicular tissues (severe congestion, bionecrotic swelling and some leucocyteremigrations in aedullary tissues and intense eeu rete swelling, severe congestion, locakised miltiple hemorrhages and intense aiming tion of lymphocytes in pulpasns sent. 412, Mesentertal: ; Almost normal, slight swelling and slight hyperplasia of medullary tissues and (4/2) ret Kable changes else, 412. Peribronchial: Extremly intense houcrrhagic ahatigas: in pericapsula: tissues (intense diffuse hemorrhages and plenty. leucocytes~emigra- tions) and extremly inteuse diffuse Lomnoerisgie chaages ain follicular tissues (the wost intense diffuse hemorrheges, necrotic swelling, at sme place submiliary bionecrotic parts and remarkable diminution of ruines follicular cell-elements in medullary tissues and remarkable aiminu- tion or diminish of pulpa-meshes).. 8 ee Lymphedinitis haemorrhagica gravis. i 412, Mesernterial: Slight pericapsulgr inflammation (with a few leucocytes) and slight catarrh (with sone histiocytes) in peripheral | sinuses. Considerable congestion and slight edemataus swelling of medullary tissues with some leucocytes and slight swelling of puplaemeshes with slight | dutniition of follicular lymphocytes, | No significant congestion in folliculer — tissues, 4T2, Mesenterial: re cba ery slight pericapsular congestion and eonsideréhie: congestion with very a slight swelling in follicular tissues, No remarkable changes else, 4r7. Peribronchial: | Considerable pericapsular hemorrhages. with considerable hemorrhagic~exudative : changes in follicular tissues: ( consider able congestion, swelling slight perivascu~ — lar hemorrhages, and some leucocytes= 7 emigration in medullary tissues and - remarkable hemorrhages, some leucocytes=- _ emigration, edematous swelling of reticulum ‘fibres and slight hyperplasia of reticu- . . lumecells which fall into BHORECIONE ; clondy swelling in pulpe-meshes » 2ccom= na re panied with remarkable diminution cz ‘ follicular lymphocytes. _ 417, Mesenterial: ; Almost normal, slight catarrh in peri- pheral sinuses and conaiderabie conge- a stion with slight hyperplasia of reticulim. cells in medullary tissues, es No significant changes else, 417, Axillar: * . Slight catarrh in peripheral sinuses, .. sk Slight congestion with slight hypér- ‘plasia ef medullary tissues, slight ©". ' reduction with slight swelling of pulpa~ meshes and slight hyperplasia of germins@- tive centers with mme cloudy swollen reticulum-cells, Se No remarkable changes else, ArT, ‘Radical mesenterials Slight pericapsuler inflammation end’ cet sitgnt exudation with some . Leucooytes” ‘in peripheral sinuses, Considerable _ congestion, bionecrotiic swelling and | plenty leucocytesmemigrations in medue-' * llary, tissues with considerable reduction | of pulpa-meshes (some leucocytes~oul gran ; tions, intense swelling of reticulum= ee _ fibres: ad considerable diminution of folliouler lymphooytes ). : 407, Parabronchials ; 2 a Lymphnodulus at bifuleation, , Extremly intense hemorrhagic exudative changes in pericapsuler tissues (the most intense diffuse hemorrhages and exudation with leusooytes), in peripheral sinuses {the samo _changes ) and aleofin follicular tissues: (the most intense : congestion, ane moste diffuse’ ‘tenor nei 2 plenty leucocytes ~emigration, pionoerotic , swelling or diminish of cellular components in medullary tissues and the most intense. reduction of pulpa-meshes with the most. intense exudation, heuorrhages, ple.ty leucocytes -omigration, necrotic ruins of reticulum-fibres and remarkable diminu- tion of a lymphocytes in pees : neshes). Lymphadenitis haemorrhagica gravis, la, al . T) me cases ‘of: ¢ porate infeotion, The bird 's-eye-view of pathological changes in all ronained’ mioreade pical slices, So S18, Lymphadenitis hhaemorrhagico-necroticans with ‘severe peri- a : of, 520, ee have only. § remained miorostopical ‘slices of nessntertal a) Mesenterial Lymphrnodes, 17. Lymphedenitie tuberculosa with considerable folliguier conge= | ation. ‘Lysiphedent tis heonervhagiee-mocreticans vite ‘severe pert ; ‘capsular, inflammation, 225. ‘Oonaiderable. follicular congestion, Rtg a a coon Porieapauler congestion and some hemorrhages, éiseapeniod with some leucocytes as capillary contents, - capsular inflammation, 225.. Lymphadenitis haemorrhagicomecroticana with slight pericap- aular inflammation, Lymph-nodes. ; ee : gs 3 of them fall into typioa} hauotrhagic-isorette ‘tnfLemmet ion, 2 of them fall into considerable follicular congestion, econ 7 panied with some. leucocytes as capillary. contents, ’ namely in- | : itiel stage of. acute inflambation, b) Peribronohial lym : 27, Considerable congestion with some leucocytes, “Adthracosis. S78. Lymphadenitia tuberculosa, 320. Gonsiderable follicular congestion and slight catarrh of sinus only’ 3 peribronchie}Z lymph -nodes ‘are remained, — ; 2 of them with considerable congestion and some ‘Ledeooytea,, a8 ) tens: of anitial stage of acute inflammation, due to .oogndary infection, No remarkable changes else, wn, IZ) The cases of pw rnasal infection; . _ ‘The bird's-eye-viw of pathological changes in all cases, : ae Mesenteriel ld, ' Peribronchial 24, 388, . Lymphadenitis haemorrhagico- Lymphadenitis Haemorrhdgico- ‘ neoroticans ae necroticans, ae 389. Slight catarrh of sinus, = Lymphadonitis haemorrha, Considerable congestion and: some necroticana, hemorrhages in. medull ary tissues ‘with some leucocytes, 393, Lymphadenitis heemorrhagico-= L, haemorrhagica, ‘necrotioans gravis, Slight oaterrh of sinus, Medullary congestion, and. Hh some hemorrhagic places. : 390, ° Lymphadenitis haemorrhagica; | Lymphadenitis haemorrhegica gravis, « i 396. No remarkable changes, ; Lymphadenitis haemorrhagica ; : gravis. . 397, : Lymphadenitis haemorrhagico- Lymphadenitis eatarrhalis necroticans gravis. levis, 390, Lymphadenitis catarrh, levis. Lymphadenitis haemorrhagico= | Slight congestion and slight levie. hemorrhages, 400. Lgmphadenitie and Periadenitis Lymphadenitis heemorrhagico= ae _, levis, ‘ - necroticans. Considerable “congestion with . 7 _ gome leucocytes in folbicles, 40r. ‘Lymphadentis haemorrhagico- Lymphedenitis haemorrhagioo ¢ | - purulenta, ; necrotioans, . = : . 403, Lymphadenitis haemorhagioco=- Lymphadenitis haemorrhagico»- . necroticans, | necroticans, | - 404, L, haemorrhagica, Periadenitis exudative gravi: Lymphadent tis catarrh ‘levis (slight congest and some leu- cocytes ) 408, Lymphadenttis acute levis, (alight congestion, exudatt nn somecencoerats lie _ and some leucocytes ) 7 gestion, Slight Pericapsular hemorr- hages, . 407. Lymphadenitis haemorrhagico= . Lymphadenits haemorrhagica, purulenta, ie 7 | a , Perisdenitis haemorrhagico- | . eee : purulenta,. ‘ 409. Lymphadenitis haemorrhagica. Lymphadenitis haemorhagica gravis. 4II. Lymphiedenitis haemorrhagica. _Lymphadenitis heemorhagics gravis. 418, Shight oatarrh of sinus, Lymphadenitis haemorrhagica _No remarkable changes, gravis, | /417, Lymphedenitis acute, _ Lymphadenitis haemorrhagica, Slight exudation, congestion : some levoocytes, Slight Perladenitis, ‘ Accordingly the comme T cases ere af following! ~ if ; ‘i Submaxillar 1d. Axiller 1d, . Lymphadenitis haemarrhagico- Lymphadenitis haemorrhagico- necroticans, necroticans, Mesenterial 1d.” L, tuberculosa, Mesenterial 1d, ; L, haemorrhagica, SL I rsp ESP reruns Axillar 1d, ; No remarkable changes, Mesenterial ld. L. acuta levis. F ; Mediestinal 1¢4,00 2 axiller 1d, ee Lymphadenitis haemorrhagica ; Lymphadenitis haemorrhagico- . gravis, . purulenta, - Peribronchiel ld. (at bifulcation), Axillar 1d, Lymphadenitis haemorrhagica ; Lymphadenitis catarrhalis levis. gravig, aye + B). Fernesal infection. a) Peribronchiolsr Lymph-moduliin; All investigated I? cases, with hémorrhagic’ (in severe degree). : or hemorrhagic-necrotic changes. I4 cases. ‘with severe Perisdenitis and considerable folliouler congestion, I ease. with slight caterrhe and slight = congestion, 2 . _ & cases, | _ Almost all cases fall into intense hemorrhagic or hemorrgsgic necrotic “changes 11 over the follicular tissues or. severe ; | perifollicular exudation, accompanied with always the most -intense hemorrhagic exudative swelling of mediastinal tissues. _ The. later, mediestinal tumours (Mediastinitis heemorrhagicp~ exeudativa) could be diagnosed. oan ty by X-rays clinically. 3 : 5 es ‘8 cases are not attended | with. severe lymphadenitis of peribron-- oe) ohial lymph -nodulus : No. 404 ‘and No. 597 case, In No, 397 cage, Anthrax -bacilius broke into alimentary canals. : after ‘Poraseal: infection. and caused ‘some intestinal disturbences,. then severe inflammation. (hemorrhagic -necretic all. over the. follicu- ler tissues ) of mesenterial _lymph -nodulus, accompanied with, remiar = of _ keable ‘ascites, The laters was the cause of death, ae In. No, 405 cases. ; Anthrax bacillus broke into aitectly palmonal ‘tissues, not ‘ sompanie® with severe onmeee of. pert pronoht el lymph nodulus and” ag pneumonias multiple ‘acinone, : as the. cause of dont, b). ¢) Pert -bronchioler drmpa-nodatas. : General sketch of these progresses in.-ali devedbiguted Gass r ‘are aa following. Submext ler or titan lymph -nodulus, ed In some cases (esp. No, 388. and No. 409), oubmexillar or ‘ axiller lymph-nodulus fa11 into intense inflamatory changes | with hemorrhagicleucccytic infiltration, B99 OS ay “stinal disturbances 80 Bs. doscriped ins chapter (), then Antony. : ‘of mosenterial 1ymph-npdes, accompanied with heworrhagio-oxuda-- ‘besides pulmonal tissues and. caused some times intense ‘tnte- : Be acute inflemmatory changes of mesenterial lymph nodulus. Dased on the investigation of survived microscopical slices, Masentérial Lymph -noaul (JEM ~ All investigated ea: with severe hemorrhagic or hemorrhagic -necrotic: changes. IO: cases, with some signs of scute oy inflammation, ~ 4 cases, Without eny remarkable changes, - 2oases, Most cases of them sre _attendedy# with severe inflanatory. changes tive swelling of lymph-nodes in heaps, gelatinous swelling of mesenterial fatty tissues and remarkable ascites. in these cases, Anthrex-bacillus broke into alimentary canal, 10 cases of them sre eccompanied with acute hemorrhagic in- flammation of mesenterie] lymphnodulus, but I could found, which I have recieved during war-time, only 2 oases with severe heniorrhagto fungous : awelling. of intestinal walle, In other 8 Cazes, Anthrax-bacillus “should intrude into meden-_ terial Lymph -nodulue , not causing severe: intestinal symptoms I may not have obtained the microscopical slices of intesiiial disturbances at inssueg Inteze congestion and intense _ edematous swelling ef follicular tissues, esp, insubepitheliar ; tissues. oe , Remarkble congestion and edematous swelling ef folliculer tiasures, WON Hyalinous swelling of perifollicular ‘ f tissues and auere ners of retLuuiiun F iad Sere X20 MBE Ib). . mcs i da, & ee ° aa : : oO : Es SSL ses a So ae Dos 4 BR. : gg ao O.2 : By. 7s) ; AG = ec : ir) . Ot. : aS : ote: S ot: fe: : . . pias “Diffuse dione » follicles Py ‘SO. 2? Mi GE ca). MH HO o BRAIN, (A) Microscop. Paestasveioh. CEREBRUM : 225, eas . ae mee Considerable congestion with leucocytic contents. Slight peri- = vascular edema, Slight degeneration of "ganglion cells with slight hyperplasia of glia cells, 325. - We % Slight stasio of meninges, : s Slight. congestion and . elight edema of brain, slight % degeneration of. ganglion cells, aun. | Slight steele of meninges. Considerable congestion and oltght pert vascular Hemorrhages and edematous: awelling. Slight degeneration of . ganglion cells with slight hyperplasia | of: cele ogiis. 388. Slight. congestion and no remarkable changes else, arr, | Gon idersbie congestion with aight perivascular honofrhag ee altant degeneration. of F Ganglion: cells. CEREBELLUM + 225. Slight etaia and congestion with sitght perivascular hemorrhage. Slight degeneration of ganglion cells. : 320, | Byte tee ; a ae No remarkable changes, ee 526, } os : p © -_ cee: “The same changes as above mentioned, : eo - 388. oa es ; . Saat dio | iy - Considerable congestion, slight perdvesmuler henorthages and alight edema of meningen, ees _ Considerable. congestion, slight perivascular hemorrhages: and slight” edematous swelling of brain, 411, : “Slight congestion and slight Herivas cules edema, Slight degeuerstion” of hesneh ion celle, a “be e nee oi oe + ee (B) SUMMARY. Cerebrum : . -Géeneraly with very alight, not severe changes, a) Meningek with slight congestion, sometimes slight perivascular. hemorrhages and slight perivascular edema, , | b) Brain-masses + slight congestion, slight perivascular edema end sometimes slight perivascular hemorrhages. Slight degeneration of ganglion ,cells (swailing, atrophia and alight tygrolysie) with more'or | less degenerative nucleus (pycnosis and Rerseryate in slight neers): . Very slight hyperplasia of glia cells, ’ a Cerebellum : 2. ; Slighter changes than in brain, Considerable congestion with sometimes. perivascular memorrhages and. e perivascular eceua:. Slight degeneration of ganglion cells, ns OW Opec eee cerebrum. i ; _M---+-- ‘Mesencephaton. - BRAIN eee, sab maa ar HEE) [ee =] =] | SE] [tt |= T] 2: [= t= TE} Te T+] i—|-J=I-f-]-) : Fd es ed ed es ss =a fe t=T=] a Eo Beaoao Se . bgp NGMIBER es oa ‘Sicanatar bay ie # Gla [=| Buea oe ore ste re rstetetefeiets . & [Lymbhoevres T= |= Pf} CovTes [= | a ee Eis Go al [|= [—{—}. [= |—{= i]. j— T= fT) FoGsen in Enice i l-j—F- AORTA, 17,26, 54, , 325, 389, 397, 403, 405, 401, 412, 413, 417, No remarkable changes. 320, 288, 390, 407, 409, 410. “Slight stdis of periadventitiel tissues. 409. Slight stasis of perisdventitial tissues snd bacterial masses in blood vessels, 393, Slight congestion of vasa vasorum of neaia, BRE * aad ca mare he PHARY NX. A) itie¥oacop. Investigation, 54. ; slight keratification anc desquanmation of epitheliums, Considerable congestion, some edeine and some pericapillar round=cell “tnfilt tration in submucous tissues, 225." 7 wee a Considerable congestion and sone round-cell-infiltration at perivascus ler and periglandular tissues, 7 z “Glandulee. pharyngese with some desquamative epitnelialiums, . STB, Intense congestion and soiie hemorrhages in stmicous tissues. Slight infiltretion of round-cells and some leucocytes in mucous paseyee and epithelisr layers, 20, a ' Slight congestion and some edema. Diffuse round-cell -dissemination (plasma-cells and some. lymphocytes’. in’ submucous tissues, Slight iy pares sete sot lymph -nofulus, % MUSCLE. tA) Microscop, Investigation. 54, Phiegmona diffusa, “Diffuse phiegmons in subcutaneous (in extraordinary intense degree) -and cutaneous: tissues with intense leucocytes (and Some iymphoogtes)- . infilltration, accompanied with severe serous exudation. and intense - diffuse hemorrhages (so-called blood-sea) : : ; Capillaries in subeutaneous tissues with plenty of leucocytes, necrom' -tic ruins» of capillar wakls, intense perivascular edema. and hemorrhages, intense levcosytes-emigration (nematogenous-metastatic charactora), Invading’ phlegmneously all over the neighbouring tissues, Accompanied with atrophic epicermis and atrophy or collapse of adnex~: * organs. 388, Remarkable oapiller congeation at Stratum | subpapiliere with me ‘anthrex-bacillus in aome capillaries. - ewe Accompanied with somewaht necrotic ruins of tee lar édema in high degree and some iSeattaed hemorrhages. Some ‘pericapiller lymphocytes (and some leucocytes})-accumilation and - slight collapse of adnex-organs. 409, _ Interse capiilar’ congestion ad 1 localisce heworrhages. at Str. subpapt - llare and str. papillere, act onpented with somewhat diffu se perivas- n \eular. cellular infilration, (leucocytes, some of them being eosino~. pnilioc,.lymphocrt:s end some histiocytes). Slight fibrosis. of adnex- , . . cen : . ao i < ‘ a In epidermis, slight swelling aid parakeratosis above the cutis, at ae peas ro phia gt pt C ee eee Kle cells ‘and sori